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9 March 2023 Combined photoacoustic microscopy and optical coherence tomography ocular biomarkers imaging in Alzheimer's disease mice
Wei Zhang, Wei Qian, Yannis Paulus M.D., Xueding Wang
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Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791C (2023) https://doi.org/10.1117/12.2647772
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Reliable and more accessible biomarkers along with advanced imaging methods are essential for early diagnosis to achieve effective therapeutic interventions of Alzheimer's disease (AD). In this study, an integrated photoacoustic microscopy (PAM) and optical coherence tomography (OCT) dual-modality ocular biomarkers imaging system was developed, and its performance was evaluated with an Alzheimer's disease mouse model. The beta amyloid deposition in retinal microvasculature were imaging by dual-wavelength PAM with near-infrared absorbing gold nanochains conjugated with anti-beta amyloid antibodies. The multi-layer retinal structure changes were investigated via OCT. With the unique ability of imaging the multiple ocular biomarkers via a single scan, the proposed system provides a new tool for investigating AD in animal models.
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Wei Zhang, Wei Qian, Yannis Paulus M.D., and Xueding Wang "Combined photoacoustic microscopy and optical coherence tomography ocular biomarkers imaging in Alzheimer's disease mice", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791C (9 March 2023); https://doi.org/10.1117/12.2647772
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KEYWORDS
Optical coherence tomography
Alzheimer's disease
Imaging systems
Photoacoustic microscopy
Animal model studies
Eye models
Gold
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