Specialized reference targets and visualization phantoms for accelerating clinical translation of intraoperative fluorescence imaging technologies

Ethan M. LaRochelle; Eammon A. Littler; Edwin A. Robledo; Sophie A. Lyon; Samuel S. Streeter; Kimberley S. Samkoe; Alberto J. Ruiz

doi:10.1117/12.3002798

13 March 2024 Specialized reference targets and visualization phantoms for accelerating clinical translation of intraoperative fluorescence imaging technologies

Ethan M. LaRochelle, Eammon A. Littler, Edwin A. Robledo, Sophie A. Lyon, Samuel S. Streeter, Kimberley S. Samkoe, Alberto J. Ruiz

Author Affiliations +

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250E (2024) https://doi.org/10.1117/12.3002798
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

There are an expanding number of contrast agents under development in the field of intraoperative fluorescence imaging. We demonstrate solid phantoms focused on addressing clinical and pre-clinical fluorophores while also incorporating tissue-mimicking optical properties. Characterization techniques and design considerations are discussed. Examples of OTL38-equivalent solid reference targets and dynamic flow phantoms are presented. Use cases are used to demonstrate how these tools reduce development time and accelerate the clinical adoption of new fluorescence imaging technologies.

Conference Presentation

Citation Download Citation

Ethan M. LaRochelle, Eammon A. Littler, Edwin A. Robledo, Sophie A. Lyon, Samuel S. Streeter, Kimberley S. Samkoe, and Alberto J. Ruiz "Specialized reference targets and visualization phantoms for accelerating clinical translation of intraoperative fluorescence imaging technologies", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250E (13 March 2024); https://doi.org/10.1117/12.3002798

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