Optical properties of in-vivo normal and burned skin in humans and swine measured using spatial frequency domain imaging (SFDI)

Gordon T. Kennedy; Rebecca Rowland; Thinh Phan; Chris Campbell; Alexis M. Fox; Earl Steward; Bernard Choi; Theresa Chin; Victor C. Joe; Anthony J. Durkin; Robert J. Christy; David M. Burmeister

doi:10.1117/12.3003470

13 March 2024 Optical properties of in-vivo normal and burned skin in humans and swine measured using spatial frequency domain imaging (SFDI)

Gordon T. Kennedy, Rebecca Rowland, Thinh Phan, Chris Campbell, Alexis M. Fox, Earl Steward, Bernard Choi, Theresa Chin, Victor C. Joe, Anthony J. Durkin, Robert J. Christy, David M. Burmeister

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Proceedings Volume PC12833, Design and Quality for Biomedical Technologies XVII; PC128330E (2024) https://doi.org/10.1117/12.3003470
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Porcine skin possesses many of the morphological and functional features of human skin and is considered an appropriate surrogate for human skin in a wide range of preclinical animal studies. Nevertheless, there are differences in structure that may affect optical measurements of the tissue health. It is, therefore, important to understand these differences in optical properties for translation of swine data and experiments to human clinical studies. Here, we compare and contrast in-vivo measurements of the optical properties of normal and burned human and porcine skin obtained using two commercial SFDI systems.

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Gordon T. Kennedy, Rebecca Rowland, Thinh Phan, Chris Campbell, Alexis M. Fox, Earl Steward, Bernard Choi, Theresa Chin, Victor C. Joe, Anthony J. Durkin, Robert J. Christy, and David M. Burmeister "Optical properties of in-vivo normal and burned skin in humans and swine measured using spatial frequency domain imaging (SFDI)", Proc. SPIE PC12833, Design and Quality for Biomedical Technologies XVII, PC128330E (13 March 2024); https://doi.org/10.1117/12.3003470

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KEYWORDS

Skin

Optical properties

In vivo imaging

Systems modeling

Tissues

Oxygen

Pathophysiology

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