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13 March 2024 Multi-needle fiberoptic Raman spectroscopy technique for simultaneous multi-site deep tissue Raman measurements in brain
Zhiwei Huang, Chi Shu, Bocheng Qiu
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Proceedings Volume PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry; PC128390E (2024) https://doi.org/10.1117/12.3008485
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We report on the development of multi-needle fiberoptic Raman spectroscopy (MNF-RS) technique for simultaneous multi-site deep tissue Raman measurements of brain. High quality tissue Raman spectra within the range of fingerprint (FP, 800 – 1800 cm-1) and high-wavenumber (HW, 2800 – 3300 cm-1) are collected within sub-second integration time using the MNF-RS technique from different tissue types (e.g., muscle, fat, gray matter and white matter from porcine brain). We advance the MNF-RS probes into deep porcine brain for validating its simultaneous Raman spectra acquisition capability from different brain regions (e.g., cortex, thalamus, midbrain and cerebellum). The distinct biochemical differences are identified among different brain locations, indicating the promising potential of MNF-RS technique for label-free neuroscience study at the molecular level.
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Zhiwei Huang, Chi Shu, and Bocheng Qiu "Multi-needle fiberoptic Raman spectroscopy technique for simultaneous multi-site deep tissue Raman measurements in brain", Proc. SPIE PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, PC128390E (13 March 2024); https://doi.org/10.1117/12.3008485
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KEYWORDS
Raman spectroscopy
Brain
Fiber optics
Brain tissue
Fiber optics tests
Algorithm development
Tissues
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