Picosecond laser pulses for precision ablation of cancerous tissue

Rainer J. Beck; Ioannis Bitharas; Thomas I. Maisey; Ryan K. Mathew; Andrew J. Moore; James Moor; Robert R. Thomson; David G. Jayne; Jonathan D. Shephard

doi:10.1117/12.3002935

13 March 2024 Picosecond laser pulses for precision ablation of cancerous tissue

Rainer J. Beck, Ioannis Bitharas, Thomas I. Maisey, Ryan K. Mathew, Andrew J. Moore, James Moor, Robert R. Thomson, David G. Jayne, Jonathan D. Shephard

Author Affiliations +

Proceedings Volume PC12840, Optical Interactions with Tissue and Cells XXXV; PC1284006 (2024) https://doi.org/10.1117/12.3002935
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The successful laser ablation of clinically relevant tissue models by means of picosecond laser pulses is presented. This is a potential alternative to overcoming limitations of conventional tumour-surgery tools in terms of precision and thermal damage. The correlation of high-speed imaging of the ablation process, schlieren imaging of the resulting plume dynamics and a histopathological analysis of the post-process tissue morphology enables optimisation of the tissue removal rate whilst avoiding adverse cavitation effects. This facilitates minimal collateral thermal damage. Effective tissue removal is presented for the epithelial laser ablation of colonic tissue; with translation of this process towards infiltrating brain and head and neck cancer surgery further discussed.

Conference Presentation

Citation Download Citation

Rainer J. Beck, Ioannis Bitharas, Thomas I. Maisey, Ryan K. Mathew, Andrew J. Moore, James Moor, Robert R. Thomson, David G. Jayne, and Jonathan D. Shephard "Picosecond laser pulses for precision ablation of cancerous tissue", Proc. SPIE PC12840, Optical Interactions with Tissue and Cells XXXV, PC1284006 (13 March 2024); https://doi.org/10.1117/12.3002935

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available