Combined photoacoustic-ultrasound and near-infrared fluorescence (PAUS-NIRF) imaging of tozuleristide within ex vivo tissue: toward optically-guided solid tumor surgery

Ruibo Shang; Amila Silva; Matthew D. Carson; Eric J. Seibel; Ivan M. Pelivanov; Matthew O'Donnell; Matthew Thompson

doi:10.1117/12.3003288

13 March 2024 Combined photoacoustic-ultrasound and near-infrared fluorescence (PAUS-NIRF) imaging of tozuleristide within ex vivo tissue: toward optically-guided solid tumor surgery

Ruibo Shang, Amila Silva, Matthew D. Carson, Eric J. Seibel, Ivan M. Pelivanov, Matthew O'Donnell, Matthew Thompson

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284231 (2024) https://doi.org/10.1117/12.3003288
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Solid tumors represent abnormal tissue masses where surgical resection is often the primary treatment. However, positive margins increase local recurrence. Near-infrared fluorescence (NIRF) can intraoperatively identify solid tumors and assess margins. However, fluorescent light is diffused at depth, resulting in poor localization. Here, we test two lab-built systems (fast-sweep spectroscopic photoacoustic-ultrasound (PAUS) and NIRF multimodal scanning fiber endoscope) in a pilot ex vivo study to localize FDA-approved Tumor Paint^® tozuleristide (BLZ-100, Blaze Bioscience, Inc.) tumor-targeted contrast agent in muscle for real-time guidance (tumor excision) by combining them for pre- (PAUS) and intra- (NIRF) operative solid tumor detection.

Citation Download Citation

Ruibo Shang, Amila Silva, Matthew D. Carson, Eric J. Seibel, Ivan M. Pelivanov, Matthew O'Donnell, and Matthew Thompson "Combined photoacoustic-ultrasound and near-infrared fluorescence (PAUS-NIRF) imaging of tozuleristide within ex vivo tissue: toward optically-guided solid tumor surgery", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284231 (13 March 2024); https://doi.org/10.1117/12.3003288

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available