Label-free in vivo imaging using photon absorption remote sensing

James A. Tummon Simmons; Sarah J. Werezak; Benjamin R. Ecclestone; James E. D. Tweel; Parsin Haji Reza

doi:10.1117/12.3002936

13 March 2024 Label-free in vivo imaging using photon absorption remote sensing

James A. Tummon Simmons, Sarah J. Werezak, Benjamin R. Ecclestone, James E. D. Tweel, Parsin Haji Reza

Proceedings Volume PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024; PC128540K (2024) https://doi.org/10.1117/12.3002936
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Vascular imaging is an essential tool for understanding tissue health in the diagnosis and treatment of disease, especially for applications in cancer and ophthalmology. This work explores the application of Photon Absorption Remote Sensing (PARS) microscopy to several established in vivo vasculature models including chicken embryo and mouse ear. Significant system improvements are presented which have enabled the repeatable acquisition of images that are larger, require less scan time, and capture detailed absorption contrast of both radiative and non-radiative relaxation. The presented work demonstrates PARS as a promising platform for future clinical evaluation of disease pathology and treatment efficacy.

Conference Presentation

Citation Download Citation

James A. Tummon Simmons, Sarah J. Werezak, Benjamin R. Ecclestone, James E. D. Tweel, and Parsin Haji Reza "Label-free in vivo imaging using photon absorption remote sensing", Proc. SPIE PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024, PC128540K (13 March 2024); https://doi.org/10.1117/12.3002936

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