Combinatorial nanomaterials platform for chemical fingerprinting of cancer-associated volatile organic compounds via surface-enhanced Raman scattering

Hannah J. O'Toole; Ambarish Kulkarni; Marie C. Heffern; Randy Carney

doi:10.1117/12.3001076

13 March 2024 Combinatorial nanomaterials platform for chemical fingerprinting of cancer-associated volatile organic compounds via surface-enhanced Raman scattering

Hannah J. O'Toole, Ambarish Kulkarni, Marie C. Heffern, Randy Carney

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Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC128590F (2024) https://doi.org/10.1117/12.3001076
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Breath biopsy holds great potential for noninvasive and early-stage cancer detection and diagnosis. Volatile organic compounds (VOCs) are low molecular weight metabolites released in breath and biofluids as the result of pathophysiological changes such as cancer. Hundreds of VOCs are expired per breath, providing an information-rich resource of diagnostic potential. To pare down the complexity of the breath volatilome and detect low concentration (ppmV to pptV) cancer-associated VOCs from ubiquitous VOCs, we have engineered a combinatorial nanoplasmonic sensor array for multiplexed adsorption of VOCs. This dual-stage platform features (1) an engineered array of selectively sorbent core-shell nanostructures consisting of plasmonic nanoparticle cores encapsulated by tunable metal-organic frameworks (MOFs) for more specific VOC capture, followed by (2) ultrasensitive readout via surface-enhanced Raman spectroscopy (SERS), i.e., a “SERS-MOF” nanomaterial sensing array. This work focuses on the nanoscale materials synthesis efforts towards lead SERS-MOFs based on ZIF-8 MOF / gold nanourchin particles and preliminary testing of the platform on relevant VOC analytical standards.

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Hannah J. O'Toole, Ambarish Kulkarni, Marie C. Heffern, and Randy Carney "Combinatorial nanomaterials platform for chemical fingerprinting of cancer-associated volatile organic compounds via surface-enhanced Raman scattering", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC128590F (13 March 2024); https://doi.org/10.1117/12.3001076

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KEYWORDS

Cancer detection

Nanomaterials

Micro optical fluidics

Raman scattering

Surface enhanced Raman spectroscopy

Cancer

Gold

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