Digital histopathology based on metasurface components for polarimetric imaging

Alexander V. Bykov; Oleksii Sieryi; Chao Meng; Paul C. V. Thrane; Christopher A. Dirdal; Sergey Bozhevolnyi; Igor V. Meglinski

doi:10.1117/12.3021686

19 June 2024 Digital histopathology based on metasurface components for polarimetric imaging

Alexander V. Bykov, Oleksii Sieryi, Chao Meng, Paul C. V. Thrane, Christopher A. Dirdal, Sergey Bozhevolnyi, Igor V. Meglinski

Author Affiliations +

Proceedings Volume PC13010, Tissue Optics and Photonics III; PC1301008 (2024) https://doi.org/10.1117/12.3021686
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Conventional histopathological methods, being time-consuming and resource-intensive, leave room for improvement with label-free optical techniques. In this study, our novel metasurface-based polarimeter has been verified for imaging of unstained histological tissue blocks and benchmarked against industrially calibrated polarization measurement systems. The novel system is based on a specifically designed metamaterial grating enabling movement/rotation-free characterization of the light polarization state, ensuring reduced measurement noise in the obtained polarimetric data. The demonstrated potential suggests a transformative, affordable, and scalable standalone system, enhancing accessibility for researchers and clinicians in polarization-based biotissue imaging.

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Alexander V. Bykov, Oleksii Sieryi, Chao Meng, Paul C. V. Thrane, Christopher A. Dirdal, Sergey Bozhevolnyi, and Igor V. Meglinski "Digital histopathology based on metasurface components for polarimetric imaging", Proc. SPIE PC13010, Tissue Optics and Photonics III, PC1301008 (19 June 2024); https://doi.org/10.1117/12.3021686

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