Finding the position of tumor inhomogeneities in a gel-like model of a human breast using 3-D pulsed digital holography

María del Socorro Hernández-Montes; Carlos Pérez López; Fernando Mendoza Santoyo

doi:10.1117/1.2717515

1 March 2007 Finding the position of tumor inhomogeneities in a gel-like model of a human breast using 3-D pulsed digital holography

María del Socorro Hernández-Montes, Carlos Pérez López, Fernando Mendoza Santoyo

Author Affiliations +

Journal of Biomedical Optics, Vol. 12, Issue 2, 024027 (March 2007). https://doi.org/10.1117/1.2717515

Abstract

3-D pulsed digital holography is a noninvasive optical method used to measure the depth position of breast tumor tissue immersed in a semisolid gel model. A master gel without inhomogeneities is set to resonate at an 810 Hz frequency; then, an identically prepared gel with an inhomogeneity is interrogated with the same resonant frequency in the original setup. Comparatively, and using only an out-of-plane sensitive setup, gel surface displacement can be measured, evidencing an internal inhomogeneity. However, the depth position cannot be measured accurately, since the out-of-plane component has the contribution of in-plane surface displacements. With the information gathered, three sensitivity vectors can be obtained to separate contributions from x, y, and z vibration displacement components, individual displacement maps for the three orthogonal axes can be built, and the inhomogeneity's depth position can be accurately measured. Then, the displacement normal to the gel surface is used to find the depth profile and its cross section. Results from the optical data obtained are compared and correlated to the inhomogeneity's physically measured position. Depth position is found with an error smaller than 1%. The inhomogeneity and its position within the gel can be accurately found, making the method a promising noninvasive alternative to study mammary tumors.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

María del Socorro Hernández-Montes, Carlos Pérez López, and Fernando Mendoza Santoyo "Finding the position of tumor inhomogeneities in a gel-like model of a human breast using 3-D pulsed digital holography," Journal of Biomedical Optics 12(2), 024027 (1 March 2007). https://doi.org/10.1117/1.2717515

Published: 1 March 2007

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 12 scholarly publications.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Digital holography

Tumors

3D modeling

Holograms

Tissue optics

Breast

Natural surfaces

Show All Keywords

RELATED CONTENT

Optical-thermal light-tissue interactions during photoacoustic imaging
Proceedings of SPIE (March 04 2014)

Breast cancer early detection via tracking of skin back scattered...
Proceedings of SPIE (February 20 2018)

Depth quantificaton for inhomogeneities within semisolid materials using 3D pulsed...
Proceedings of SPIE (June 21 2006)

Depth position measurement of inhomogeneities in semi solid organic materials...
Proceedings of SPIE (February 10 2006)

Optoacoustic images of early cancer in forward and backward modes
Proceedings of SPIE (October 24 2001)

Optical imaging diagnostics of bladder tissue with optical coherence tomography
Proceedings of SPIE (June 17 2002)

Study on dynamics of photon migration in human breast based...
Proceedings of SPIE (February 26 2010)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years