Optimizing in vivo small animal Cerenkov luminescence imaging

Antonello E. Spinelli; Federico Boschi

doi:10.1117/1.JBO.17.4.040506

23 April 2012 Optimizing in vivo small animal Cerenkov luminescence imaging

Antonello E. Spinelli, Federico Boschi

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 4, 040506 (April 2012). https://doi.org/10.1117/1.JBO.17.4.040506

Abstract

In vivo Cerenkov luminescence imaging is a rapidly growing molecular imaging research field based on the detection of Cerenkov radiation induced by beta particles when traveling though biological tissues. We investigated theoretically the possibility of enhancing the number of the detected Cerenkov photons in the near infrared (NIR) region of the spectrum. The analysis is based on applying a photon propagation diffusion model to Cerenkov photons in the tissue. Results show that despite the smaller number of Cerenkov photons in the NIR region, the fraction exiting the tissues is greater than in the visible range, and thus, a charge-coupled device detector optimized for the NIR range will allow to obtain a higher signal. The comparison was performed considering Cerenkov point sources located at different depths inside the animal. We concluded that the improvement can be up to 35% and is more significant when the Cerenkov source to be imaged is located deeper inside the animal.

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Antonello E. Spinelli and Federico Boschi "Optimizing in vivo small animal Cerenkov luminescence imaging," Journal of Biomedical Optics 17(4), 040506 (23 April 2012). https://doi.org/10.1117/1.JBO.17.4.040506

Published: 23 April 2012

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KEYWORDS

Near infrared

Photons

Tissues

Sensors

Charge-coupled devices

Cerenkov radiation imaging

Signal detection

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