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5 September 2013 Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy
Andrew J. Radosevich, Nikhil N. Mutyal, Ji Yi, Yolanda Stypula-Cyrus, Jeremy D. Rogers, Michael J. Goldberg M.D., Laura Bianchi, Shailesh Bajaj, Hemant K. Roy
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Journal of Biomedical Optics, Vol. 18, Issue 9, 097002 (September 2013). https://doi.org/10.1117/1.JBO.18.9.097002
Abstract
Optical characterization of biological tissue in field carcinogenesis offers a method with which to study the mechanisms behind early cancer development and the potential to perform clinical diagnosis. Previously, low-coherence enhanced backscattering spectroscopy (LEBS) has demonstrated the ability to discriminate between normal and diseased organs based on measurements of histologically normal-appearing tissue in the field of colorectal (CRC) and pancreatic (PC) cancers. Here, we implement the more comprehensive enhanced backscattering (EBS) spectroscopy to better understand the structural and optical changes which lead to the previous findings. EBS provides high-resolution measurement of the spatial reflectance profile P(r s ) between 30 microns and 2.7 mm, where information about nanoscale mass density fluctuations in the mucosa can be quantified. A demonstration of the length-scales at which P(r s ) is optimally altered in CRC and PC field carcinogenesis is given and subsequently these changes are related to the tissue’s structural composition. Three main conclusions are made. First, the most significant changes in P(r s ) occur at short length-scales corresponding to the superficial mucosal layer. Second, these changes are predominantly attributable to a reduction in the presence of subdiffractional structures. Third, similar trends are seen for both cancer types, suggesting a common progression of structural alterations in each.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Andrew J. Radosevich, Nikhil N. Mutyal, Ji Yi, Yolanda Stypula-Cyrus, Jeremy D. Rogers, Michael J. Goldberg M.D., Laura Bianchi, Shailesh Bajaj, and Hemant K. Roy "Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy," Journal of Biomedical Optics 18(9), 097002 (5 September 2013). https://doi.org/10.1117/1.JBO.18.9.097002
Published: 5 September 2013
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Cited by 28 scholarly publications.
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KEYWORDS
Biopsy
Error control coding
Optical properties
Backscatter
Cancer
Tissue optics
Scattering
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