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6 August 2014 Monitoring of interaction of low-frequency electric field with biological tissues upon optical clearing with optical coherence tomography
Adrian F. Peña, Alexander Doronin, Valery V. Tuchin, Igor V. Meglinski
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Journal of Biomedical Optics, Vol. 19, Issue 8, 086002 (August 2014). https://doi.org/10.1117/1.JBO.19.8.086002
Abstract
The influence of a low-frequency electric field applied to soft biological tissues ex vivo at normal conditions and upon the topical application of optical clearing agents has been studied by optical coherence tomography (OCT). The electro-kinetic response of tissues has been observed and quantitatively evaluated by the double correlation OCT approach, utilizing consistent application of an adaptive Wiener filtering and Fourier domain correlation algorithm. The results show that fluctuations, induced by the electric field within the biological tissues are exponentially increased in time. We demonstrate that in comparison to impedance measurements and the mapping of the temperature profile at the surface of the tissue samples, the double correlation OCT approach is much more sensitive to the changes associated with the tissues’ electro-kinetic response. We also found that topical application of the optical clearing agent reduces the tissues’ electro-kinetic response and is cooling the tissue, thus reducing the temperature induced by the electric current by a few degrees. We anticipate that dcOCT approach can find a new application in bioelectrical impedance analysis and monitoring of the electric properties of biological tissues, including the resistivity of high water content tissues and its variations.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2014/$25.00 © 2014 SPIE
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Adrian F. Peña, Alexander Doronin, Valery V. Tuchin, and Igor V. Meglinski "Monitoring of interaction of low-frequency electric field with biological tissues upon optical clearing with optical coherence tomography," Journal of Biomedical Optics 19(8), 086002 (6 August 2014). https://doi.org/10.1117/1.JBO.19.8.086002
Published: 6 August 2014
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Cited by 11 scholarly publications.
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KEYWORDS
Tissues
Optical coherence tomography
Optical clearing
Temperature metrology
Electrodes
Natural surfaces
Electronic filtering
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