Reconstruction of high-resolution early-photon tomography based on the first derivative of temporal point spread function

Jiaju Cheng; Chuangjian Cai; Jianwen Luo

doi:10.1117/1.JBO.23.6.060503

25 June 2018 Reconstruction of high-resolution early-photon tomography based on the first derivative of temporal point spread function

Jiaju Cheng, Chuangjian Cai, Jianwen Luo

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Journal of Biomedical Optics, Vol. 23, Issue 6, 060503 (June 2018). https://doi.org/10.1117/1.JBO.23.6.060503

Abstract

For fluorescence molecular tomography, higher spatial resolution can be achieved using minimally scattered early photons. Conventional reconstruction methods of early photon tomography (EPT) are based on the integral of temporal point spread function (TPSF), which may lead to poor image quality due to systematic noise and time mismatch between the TPSF data and forward model. The derivative of the rising portion of TPSF is proposed to be used in EPT to increase the performance of reconstruction because the derivative is less sensitive to noise and time mismatch than the integral. A method based on projected Tikhonov regularization with the reconstructed result of steepest descent algorithm as a priori information is developed. Using the derivative of TPSF, the method can achieve high spatial resolution in phantom experiments and is capable of separating targets with an edge–edge distance of 1.5 mm.

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Jiaju Cheng, Chuangjian Cai, and Jianwen Luo "Reconstruction of high-resolution early-photon tomography based on the first derivative of temporal point spread function," Journal of Biomedical Optics 23(6), 060503 (25 June 2018). https://doi.org/10.1117/1.JBO.23.6.060503

Received: 27 February 2018; Accepted: 5 June 2018; Published: 25 June 2018

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