Natural zeolite for adsorbing and release of functional materials

Vladimir Ararat Hovhannisyan; Chen-Yuan Dong; Feng-Jie Lai; Nan-Shan Chang; Shean-Jen Chen

doi:10.1117/1.JBO.23.9.091411

1 June 2018 Natural zeolite for adsorbing and release of functional materials

Vladimir Ararat Hovhannisyan, Chen-Yuan Dong, Feng-Jie Lai, Nan-Shan Chang, Shean-Jen Chen

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 9, 091411 (June 2018). https://doi.org/10.1117/1.JBO.23.9.091411

Abstract

Using multiphoton microscopy (MPM), we demonstrated that effective inducing of two-photon excited luminescence and second-harmonic generation signals in nano/microparticles of clinoptilolite type of zeolite (CZ) by femtosecond near-infrared laser excitation can be successfully utilized in multiphoton imaging of the drug adsorption processes. Adsorption of photodynamic active dyes (hypericin, chlorin e₆, methylene blue, and fluorescein) and their release from CZ pores in the presence of biomolecules, such as collagen from bovine Achilles tendon, albumin, and hemoglobin, were investigated by absorption and fluorescence spectrometry. To quantify the experimental results on hypericin release, here we use a kinetic curves fitting approach and calculate hypericin release rates in different environments. This approach allows to compare various mathematical models and uses more parameters to better characterize drug release profiles. In addition, magnetic CZ particles were fabricated and proposed as a promising material for drug delivery and controlled release in biological systems. Optical spectrometry and MPM are effective approaches that may reveal potential of natural zeolites in controlled drug delivery and biomedical imaging.

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Vladimir Ararat Hovhannisyan, Chen-Yuan Dong, Feng-Jie Lai, Nan-Shan Chang, and Shean-Jen Chen "Natural zeolite for adsorbing and release of functional materials," Journal of Biomedical Optics 23(9), 091411 (1 June 2018). https://doi.org/10.1117/1.JBO.23.9.091411

Received: 15 January 2018; Accepted: 15 May 2018; Published: 1 June 2018

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KEYWORDS

Particles

Zeolites

Magnetism

Luminescence

Molecules

Adsorption

Collagen

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