Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages

Zongxi Li; Haley Marks; Conor L. Evans; Gabriela Apiou-Sbirlea

doi:10.1117/1.JBO.24.2.021201

27 December 2018 Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages

Zongxi Li, Haley Marks, Conor L. Evans, Gabriela Apiou-Sbirlea

Author Affiliations +

Journal of Biomedical Optics, Vol. 24, Issue 2, 021201 (December 2018). https://doi.org/10.1117/1.JBO.24.2.021201

Abstract

This article aims to be a progress report on the Sensing, Monitoring And Release of Therapeutics (SMART) bandage—one of the three technologies that received the inaugural SPIE Photonics West Translational Research Symposium Award in 2015. Invented and developed by Dr. Conor L. Evans and his research team at the Wellman Center for Photomedicine, Massachusetts General Hospital, the SMART bandage is a tool aiming to provide measurements of physiological parameters in the skin alongside the administration of therapeutics on-demand. Since the project began in 2012, the chemists, physicists, and biomedical engineers in the team have worked closely with partners from academia and industry to develop oxygen-sensing SMART bandage prototypes that are now in first-in-human clinical studies. This report gives perspectives on the genesis and translational journey of the technology with an emphasis on the challenges encountered, and the solutions innovated at each stage of development.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Zongxi Li, Haley Marks, Conor L. Evans, and Gabriela Apiou-Sbirlea "Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages," Journal of Biomedical Optics 24(2), 021201 (27 December 2018). https://doi.org/10.1117/1.JBO.24.2.021201

Received: 14 August 2018; Accepted: 14 November 2018; Published: 27 December 2018

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Cited by 17 scholarly publications and 1 patent.

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KEYWORDS

Oxygen

Tissues

Skin

Cameras

Prototyping

Biomedical optics

Surgery

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