Volume 30 Issue 1 | Journal of Biomedical Optics

Journal of Biomedical Optics

VOL. 30 · NO. 1 | January 2025

ISSUES IN PROGRESS

IN PROGRESS

SPIE publishes accepted journal articles as soon as they are approved for publication. Journal issues are considered In Progress until all articles for an issue have been published. Articles published ahead of the completed issue are fully citable.

IN THIS ISSUE

Editorial (1)

Imaging (2)

Therapeutic (1)

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Editorial

JBO 2024 List of Reviewers

Journal of Biomedical Optics, Vol. 30, Issue 01, 010102, (January 2025) https://doi.org/10.1117/1.JBO.30.1.010102

TOPICS: Lithium, Chaos, Sun, Rain, Nickel, Molybdenum, Lutetium, Gallium nitride, Fluctuations and noise, Content addressable memory

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Imaging

Comparative analysis of intraoperative thermal and optical imaging for identification of the human primary sensory cortex

Juliane Müller, Martin Oelschlägel, Stephan Sobottka, Matthias Kirsch, Gerald Steiner, Edmund Koch, Christian Schnabel

Journal of Biomedical Optics, Vol. 30, Issue 01, 016002, (January 2025) https://doi.org/10.1117/1.JBO.30.1.016002

TOPICS: Brain, Tumors, Optical imaging, Visualization, Surgery, Brain mapping, Biological research, Spatial resolution, Somatosensory cortex, Thermography

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Significance

The precise identification and preservation of functional brain areas during neurosurgery are crucial for optimizing surgical outcomes and minimizing postoperative deficits. Intraoperative imaging plays a vital role in this context, offering insights that guide surgeons in protecting critical cortical regions.

Aim

We aim to evaluate and compare the efficacy of intraoperative thermal imaging (ITI) and intraoperative optical imaging (IOI) in detecting the primary somatosensory cortex, providing a detailed assessment of their potential integration into surgical practice.

Approach

Data from nine patients undergoing tumor resection in the region of the somatosensory cortex were analyzed. Both IOI and ITI were employed simultaneously, with a specific focus on the areas identified as the primary somatosensory cortex (S1 region). The methodologies included a combination of imaging techniques during distinct phases of rest and stimulation, confirmed by electrophysiological monitoring of somatosensory evoked potentials to verify the functional areas identified by both imaging methods. The data were analyzed using a Fourier-based analytical framework to distinguish physiological signals from background noise.

Results

Both ITI and IOI successfully generated reliable activity maps following median nerve stimulation. IOI showed greater consistency across various clinical scenarios, including those involving cortical tumors. Quantitative analysis revealed that IOI could more effectively differentiate genuine neuronal activity from artifacts compared with ITI, which was occasionally prone to false positives in the presence of cortical abnormalities.

Conclusions

ITI and IOI produce comparable functional maps with moderate agreement in Cohen’s kappa values. Their distinct physiological mechanisms suggest complementary use in specific clinical scenarios, such as cortical tumors or impaired neurovascular coupling. IOI excels in spatial resolution and mapping reliability, whereas ITI provides additional insights into metabolic changes and tissue properties, especially in pathological areas. Combined, these modalities could enhance the understanding and analysis of functional and pathological processes in complex neurosurgical cases.

Robust estimation of skin physiological parameters from hyperspectral images using Bayesian neural networks

Teo Manojlović, Tadej Tomanič, Ivan Štajduhar, Matija Milanič

Journal of Biomedical Optics, Vol. 30, Issue 01, 016004, (January 2025) https://doi.org/10.1117/1.JBO.30.1.016004

TOPICS: Artificial neural networks, Data modeling, Skin, RGB color model, Education and training, Hyperspectral imaging, Tissues, Nervous system, Performance modeling, In vivo imaging

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Therapeutic

Photosensitizer spatial heterogeneity and its impact on personalized interstitial photodynamic therapy treatment planning

Tina Saeidi, Shuran Wang, Hector Contreras, Michael Daly, Vaughn Betz, Lothar Lilge

Journal of Biomedical Optics, Vol. 30, Issue 01, 018001, (January 2025) https://doi.org/10.1117/1.JBO.30.1.018001

TOPICS: Picosecond phenomena, Tumors, Photodynamic therapy, Tissues, Spatial resolution, Animals, Brain, Animal model studies, Spherical lenses, Statistical analysis

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