Comparison of oxyhemoglobin and deoxyhemoglobin signal reliability with and without global mean removal for digit manipulation motor tasks

Swethasri Dravida; Jack Adam Noah; Xian Zhang; Joy Hirsch

doi:10.1117/1.NPh.5.1.011006

14 September 2017 Comparison of oxyhemoglobin and deoxyhemoglobin signal reliability with and without global mean removal for digit manipulation motor tasks

Swethasri Dravida, Jack Adam Noah, Xian Zhang, Joy Hirsch

Author Affiliations +

Funded by: National Institutes of Health (NIH), National Institute of Mental Health (NIMH), National Institute of the Mental Health of the National Institutes of Health, National Institute of Mental Health, US National Institutes of Health (NIH)

Neurophotonics, Vol. 5, Issue 1, 011006 (September 2017). https://doi.org/10.1117/1.NPh.5.1.011006

Abstract

Functional near-infrared spectroscopy (fNIRS) could be well suited for clinical use, such as measuring neural activity before and after treatment; however, reliability and specificity of fNIRS signals must be ensured so that differences can be attributed to the intervention. This study compared the test–retest and longitudinal reliability of oxyhemoglobin and deoxyhemoglobin signals before and after spatial filtering. In the test–retest experiment, 14 participants were scanned on 2 days while performing four right-handed digit-manipulation tasks. Group results revealed greater test–retest reliability for oxyhemoglobin than deoxyhemoglobin signals and greater spatial specificity for the deoxyhemoglobin signals. To further characterize reliability, a longitudinal experiment was conducted in which two participants repeated the same motor tasks for 10 days. Beta values from the two tasks with the lowest and highest test–retest reliability, respectively, in the spatially filtered deoxyhemoglobin signal are reported as representative findings. Both test–retest and longitudinal methods confirmed that task and signal type influence reliability. Oxyhemoglobin signals were more reliable overall than deoxyhemoglobin, and removal of the global mean reduced reliability of both signals. Findings are consistent with the suggestion that systemic components most prevalent in the oxyhemoglobin signal may inflate reliability relative to the deoxyhemoglobin signal, which is less influenced by systemic factors.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Swethasri Dravida, Jack Adam Noah, Xian Zhang, and Joy Hirsch "Comparison of oxyhemoglobin and deoxyhemoglobin signal reliability with and without global mean removal for digit manipulation motor tasks," Neurophotonics 5(1), 011006 (14 September 2017). https://doi.org/10.1117/1.NPh.5.1.011006

Received: 8 March 2017; Accepted: 21 August 2017; Published: 14 September 2017

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