KEYWORDS: Tissue optics, Optical spectroscopy, Spectroscopy, Near infrared spectroscopy, Heart, 3D metrology, Tissues, Reflectance spectroscopy, Monte Carlo methods, In vitro testing
Epicardial catheter ablation has been increasingly recognized as an important adjunct in treating ventricular arrhythmias unamenable by endocardial ablation alone. The presence of epicardial adipose tissue (EAT) is a primary cause for ineffective ablation energy delivery and electrogram misinterpretation. To address this need, we propose a catheter-based near-infrared spectroscopic technique for mapping EAT and lesion deposition, and validate it within excised human donor hearts. We introduce a new parameter, the adipose contrast index (ACI), for rapid lipid assessment. Strong correspondence was observed between values derived from interpolated 3-dimensional ACI maps and histologically-determined EAT layer thickness (Pearson’s, R = 0.903).
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