Dr. Anahita Pilvar Profile

Dr. Anahita Pilvar

Doctoral Candidate at Boston Univ

SPIE Involvement:

Author

Area of Expertise:

Diffuse Optics , Biomedical Imaging , SFDI

Publications (12)

SPIE Journal Paper | 12 September 2024 Open Access

Enhanced peripheral tissue oxygenation and hemoglobin concentration after a high-fat meal measured with spatial frequency domain imaging

Anahita Pilvar, Jorge Plutzky, Darren Roblyer

BIOS, Vol. 1, Issue 02, 025004, (September 2024) https://doi.org/10.1117/12.10.1117/1.BIOS.1.2.025004

KEYWORDS: Tissues, Blood, Blood pressure, Optical properties, Oxygenation, Hemodynamics, Glucose, Biomedical optics, Heart, Scattering

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SignificanceThe magnitude and temporal dynamics of changes in blood nutrient and lipid levels following a high-fat meal have been previously shown to be an important indicator of current and future cardiovascular health and disease. Measurement of circulating nutrients and lipids currently requires invasive blood draws. The development of a non-invasive method for continuous monitoring of postprandial (i.e., after-meal) changes may assist in enhancing cardiovascular health management, dietary monitoring, and identification of disease-promoting factors. Spatial frequency domain imaging (SFDI) is a non-contact, label-free optical technique that can quantify tissue optical properties and hemodynamics in vivo. We hypothesized that SFDI may track the postprandial state in peripheral tissue.AimWe aim to investigate the relationship between postprandial factors, namely triglycerides and glucose, and the optical properties and oxygenation of peripheral tissue measured with SFDI.ApproachFifteen healthy volunteers consumed both a low- (2 g) and high- (60 g) fat meal on different days. A custom SFDI device was used to measure the dorsal hand surface of volunteers before the meal and each hour for 5 h after the meal. Measurements were taken at 730, 880, and 1100 nm. Longitudinal postprandial changes in tissue optical properties were correlated with changes in blood triglycerides and glucose levels as well as blood pressure, heart rate, and room temperature. A machine-learning model was trained to estimate triglyceride levels from SFDI metrics.ResultsSeveral SFDI metrics increased and peaked 3 to 4 h following the high-fat meal, including tissue oxygen saturation (StO2) and oxyhemoglobin (HbO2) concentration, and were substantially different from the low-fat cohort (p<0.05 at 3 h). The increases were large, >5% for StO2 and >10% for HbO2 concentration on average. The temporal changes in these metrics broadly tracked triglyceride levels, which peaked at 3 h post-meal. The predictive model accurately estimated blood triglyceride levels (RMSE 40 mg/dL).ConclusionThese findings suggest that SFDI could serve as a powerful non-invasive tool to monitor postprandial hemodynamics. In the future, SFDI measurements may help enhance cardiovascular disease prediction and management.

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Proceedings Article | 13 March 2024 Presentation

Spatial frequency domain imaging (SFDI) for the assessment of disease progression in scleroderma

Aarohi Mehendale, Anahita Pilvar, Kavon Karrobi, Hung Vo, Andreea Bujor, Darren Roblyer

Proceedings Volume PC12816, PC128160B (2024) https://doi.org/10.1117/12.2691937

KEYWORDS: Diseases and disorders, Skin, Control systems, Tissues, Diffuse optical imaging, Scattering, Reflectivity, Reflection, Optical properties, Histopathology

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Proceedings Article | 13 March 2024 Presentation

Preliminary design of a handheld spatial frequency domain imager for quantitative scleroderma skin assessment

Aarohi Mehendale, Kavon Karrobi, Anahita Pilvar, Andreea Bujor, Darren Roblyer

Proceedings Volume PC12827, PC1282709 (2024) https://doi.org/10.1117/12.2691936

KEYWORDS: Skin, Imaging systems, Design and modelling, Diseases and disorders, Light scattering, Diffuse optical imaging, Transparency, Reliability, Prototyping, Printing

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SPIE Journal Paper | 12 June 2023 Open Access

Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning

Samuel S. Spink, Anahita Pilvar, Lina Lin Wei, Jodee Frias, Kylee Anders, Sabrina T. Franco, Olivia Claire Rose, Megan Freeman, Grace Bag, Huiru Huang, Darren Roblyer

JBO, Vol. 28, Issue 09, 094808, (June 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.9.094808

KEYWORDS: Short wave infrared radiation, Near infrared, Scattering, Emulsions, Education and training, Shortwaves, Infrared radiation, Tissues, Absorption, Simulations

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SPIE Journal Paper | 8 June 2023 Open Access

Feasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation

Anahita Pilvar, Declan Smith, Jorge Plutzky, Darren Roblyer

JBO, Vol. 28, Issue 06, 065002, (June 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.6.065002

KEYWORDS: Blood, Particles, Mie scattering, Scattering, Simulations, Refractive index, Optical properties, Red blood cells, Plasma, Chemical vapor deposition

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Proceedings Article | 15 March 2023 Poster + Paper

Shortwave-infrared spatial frequency domain imaging for quantifying water and lipid concentrations in tissue

Thomas Livecchi, Anahita Pilvar, Ben Urban, Hrebesh Subhash, Steven Jacques, Darren Roblyer, Mark Pierce

Proceedings Volume 12363, 123630A (2023) https://doi.org/10.1117/12.2651290

KEYWORDS: Tissues, Water content, Skin, Short wave infrared radiation, Light sources and illumination, Biological samples, Biological imaging, Absorption, Chromophores, Scattering

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Proceedings Article | 7 March 2023 Presentation

Scattering and hemodynamic changes after a high-fat meal measured with SFDI

Anahita Pilvar, Declan Smith, Thomas Livecchi, Mark Pierce, Jorge Plutzky, Darren Roblyer

Proceedings Volume PC12376, PC123760L (2023) https://doi.org/10.1117/12.2650724

KEYWORDS: Short wave infrared radiation, Scattering, Blood, Hemodynamics, Shortwaves, Mie scattering, Infrared radiation, Infrared imaging, Tissue optics, Particles

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SPIE Journal Paper | 17 June 2022 Open Access

Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties

Anahita Pilvar, Jorge Plutzky, Mark Pierce, Darren Roblyer

JBO, Vol. 27, Issue 06, 066003, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.6.066003

KEYWORDS: Short wave infrared radiation, Optical properties, Skin, Tissue optics, Spatial frequencies, Blood, Infrared radiation, Infrared imaging, Shortwaves, Scattering

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Proceedings Article | 7 March 2022 Presentation

Clinic-ready shortwave infrared spatial frequency domain imaging (SWIR SFDI) system for non-invasive monitoring of postprandial blood lipids

Anahita Pilvar, Mark Pierce, Jorge Plutzky, Darren Roblyer

Proceedings Volume PC11944, PC119440H (2022) https://doi.org/10.1117/12.2608185

KEYWORDS: Short wave infrared radiation, Imaging systems, Blood, Shortwaves, Infrared radiation, Infrared imaging, Blood vessels, Tissue optics, Optical properties, Chemical vapor deposition

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Proceedings Article | 7 March 2022 Presentation

Spatial frequency domain imaging (SFDI) to quantify skin fibrosis in patients with scleroderma

Anahita Pilvar, Andreea Bujor, Darren Roblyer

Proceedings Volume PC11934, PC1193402 (2022) https://doi.org/10.1117/12.2608182

KEYWORDS: Skin, Tissue optics, Collagen, Biopsy, Scattering, Scatter measurement, Optical testing, Optical properties, Modulation, Gold

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Proceedings Article | 5 March 2021 Presentation

Shortwave infrared (SWIR) spatial frequency domain imaging (SFDI) for monitoring optical property changes in blood after a high fat meal

Anahita Pilvar, Matthew Applegate, Mark Pierce, Darren Roblyer

Proceedings Volume 11639, 116391A (2021) https://doi.org/10.1117/12.2577234

KEYWORDS: Short wave infrared radiation, Blood, Optical properties, Shortwaves, Infrared radiation, Infrared imaging, Absorption, Spatial frequencies, Optical tracking, Optical testing

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Proceedings Article | 4 March 2019 Presentation

Towards in vivo preclinical monitoring of multiscale vascular structure-function relationships in resistant breast cancers with an integrated diffuse and nonlinear imaging system (Conference Presentation)

Kavon Karrobi, Anahita Pilvar, Anup Tank, Kshama Doshi, David Waxman, Darren Roblyer

Proceedings Volume 10871, 108710E (2019) https://doi.org/10.1117/12.2508872

KEYWORDS: In vivo imaging, Tumors, Breast cancer, Imaging systems, Brain-machine interfaces, Resistance, Therapeutics, Tissues, Preclinical imaging, Nonlinear optics

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Showing 5 of 12 publications

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