Dr. Andrew L. Darling Profile

Dr. Andrew L. Darling

Reasearch Associate at Dartmouth College

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Proceedings Article | 20 February 2007 Paper

Interstitial fluid pressure due to externally applied force in breast tissue

Andrew Darling, Phaneendra Yalavarthy, Hamid Dehghani, Brian Pogue

Proceedings Volume 6431, 64310Z (2007) https://doi.org/10.1117/12.700491

KEYWORDS: Tissues, Tumors, Breast, Finite element methods, Natural surfaces, Solids, Microfluidics, Near infrared, Vegetable oil, Composites

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Manipulation of Interstitial Fluid Pressure (IFP) has clinical potential when used in conjunction with near infrared spectroscopy for detection and characterization of breast cancer. IFP is a function of blood chemistry, vessel microanatomy, mechanical properties of the tissue, tissue geometry, and external force. IFP has been demonstrated higher in tumors than normal tissue, and it has been suggested that increased IFP can lead to changes in near infrared absorbing and scattering coefficients. While it is known that external forces can increase IFP, the relationship of force to IFP in a viscoelastic, hyperelastic solid such as tissue is complex. Fluid pressure measurements were taken in gelatin phantoms of equivalent elastic modulus to adipose and glandular tissues of the breast using a WaveMap pressure transducer. 3D pressure maps were obtained for the volumes of the phantoms with an externally applied force of 10mmHg, demonstrating the contribution of shear stress, non-linear mechanical properties, and tissue geometry. Linear elastic computational models were formulated for breast tissue with and without an inclusion of tumor-like mechanical properties. Comparison of experimental and computational model data indicates that light external pressure can lead to heterogeneous IFP distribution within tissues and increased IFP gradients around tumor-like inclusions.

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