Cross-polarization (CP) OCT is a so-called functional extension of OCT that seems to have benefits in visualization of myelin. During surgery it may be quite useful receiving information concerning myelination rate in white matter surrounding tumor mass. It this study it was shown that the quantification of peritumoral white matter using pseudocolor en-face OCT maps based on three optical coefficients (the rate of attenuation in the co- and cross-channel, and the interchannel attenuation difference) correlated well with histological data. Therefore, accurate quantitative CP OCT assessment of peritumoral white matter condition supports the developing the intraoperative implementation of this method.
The work is devoted to experimental research of the method of near-field microwave diagnostics of burn wounds. This method has been tested and calibrated in controlled condition by measurements of two-layered medium «spirit-teflon». The complex dielectric permittivity of skin tissues with thermal injury was measured using the constructed sensors with sounding depth 3 and 5 mm. It is experimentally established the permittivity of the burn wound is less than intact skin. The dependence of the electrodynamics parameters from the burn’s depth was established, which can be used for express analysis degree of thermal wound.
Optical coherence tomography (OCT) is a promising method for clarifying the boundaries of the infiltrative brain tumors within surrounding white matter. Since gliomas often tend to grow close to eloquent brain areas, the question of the proximity of the tumor to white matter tracts sharply arise during tumor resection to prevent their damage. Crosspolarization (CP) OCT is a so-called functional extension of OCT that seems to have benefits in visualization of myelin. It looks perspective not just to detect white matter, but also receive information about its condition – the myelination rate and presence of ordered fibers. The aim of this study was to visualize white matter organization of eloquent brain areas with CP OCT using post-processing methods. The ex vivo CP OCT images were collected from autopsy subjects of the human brain. The brain specimens contained white matter of different organization and localization: brainstem, corpus callosum, frontal and parietal tracts, subcortical white matter. Two optical coefficients (attenuation and inter-channel attenuation difference) were calculated for each A-scan and two types of color-coded maps based on them were built. No significant differences based on CP OCT attenuation and inter-channel attenuation difference coefficients were demonstrated between white matter from different brain areas. However, in vivo studies can show conversely results. The detection of white matter microstructure during surgery looks promising therefore additional CP OCT performance build-up can be considered.
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