For investigation of accommodation and presbyopia, the ciliary body and its dynamics were imaged with Optical Coherence Tomography (OCT) method. We used two OCT systems; a discretely-swept frequency-comb OCT with a center wavelength at 1.6µ and ultra-fast spectral domain OCT with a center wavelength at 1.3μm. Measurements of dynamical modification of the ciliary body were carried out with ranging in age from 22 to 79. The OCT images and movies represent the changes of the ciliary body in the relaxed state and accommodated state. Modification in the ciliary body with accommodation was more evident for the younger subject group from the results of 2D imaging. The time dependent 3D movies of ciliary body dynamics were observed for the first time using ultra-fast spectral domain OCT system. The time duration of ciliary body thickness change in relation to the accommodation was measured from the movies.
We have developed swept source optical coherence tomography (OCT) system with an optical comb swept source
system. The swept source system comprised of two super-structured grating distributed Bragg reflector lasers covering a
wavelength range from 1561-1693 nm. A method to scan these lasers to obtain an interference signal without stitching
noises, which are inherent in these lasers, and to connect two lasers without concatenation noise is explained. Method to
reduce optical aliasing noises in this optical comb swept laser OCT is explained and demonstrated based on the
characteristic of the optical aliasing noises in this particular OCT system. By reduction of those noises, a sensitivity of
124 dB was realized. The A-scan rate, resolution and depth range were 3.1 kHz, 16 μm (in air) and 12 mm, respectively.
Deep imaging penetration into tissue is demonstrated for two selected samples.
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