Dr. Blake A. Simmons Profile

Dr. Blake A. Simmons

at Sandia National Labs

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Publications (6)

Proceedings Article | 18 April 2021 Presentation

Radiobiological studies with laser-driven protons at the BELLA PW

Lieselotte Obst-Huebl, Jianhui Bin, Jian-Hua Mao, Laura Geulig, Hang Chang, Kei Nakamura, Qing Ji, Jared De Chant, Anthony Gonsalves, Li He, Stepan Bulanov, Carl Schroeder, Cameron Geddes, Blake Simmons, Thomas Schenkel, Eleanor Blakeley, Antoine Snijders, Sven Steinke, Eric Esarey

Proceedings Volume 11790, 117900B (2021) https://doi.org/10.1117/12.2596505

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We established an experimental platform for the investigation of the radiobiological effects of stable few-MeV laser-accelerated ions at the BELLA Center using a peak laser pulse intensity of 2x1019 W cm-2 [1]. The focal spot size of laser pulses from the BELLA PW laser system is large compared to that found in typical laser-driven ion beamlines, which resulted in reduced divergence and increased ion numbers [2]. Such beams are ideally suited for subsequent capture and transport with an active plasma lens (APL) [3]. Combined with our high shot rate capability (0.2 Hz), around 1000 shots at ultra-high instantaneous dose rates (0.6 Gy/shot resulting in 107 Gy/s), with a uniform dose distribution over a 1 cm diameter lateral area, could thus be delivered to biological cell sample cups, located in air at 1.7 m distance from the laser-target interaction. The proton beamline was complemented by online (integrating current transformer and scintillator) and offline (radiochromic films) beam diagnostics for dosimetry. This assembly was used to investigate the differential sparing of healthy tissues versus the tumor response under reduced oxygen conditions. This talk gives details on the proton beamline, dosimetry as well as preliminary cell irradiation results. This work is supported by U.S. Department of Energy Office of Science, Offices of High Energy Physics and Fusion Energy Sciences, Contract No. DE-AC02-05CH11231 and LBNL Laboratory Directed Research and Development Grant, PI A. M. Snijders [1] K. Nakamura, et al., Diagnostics, Control and Performance Parameters for the BELLA High Repetition Rate Petawatt Class Laser, IEEE J. Quantum Electron., 53, (2017), 1200121 [2] S. Steinke, et al., Acceleration of high charge ion beams with achromatic divergence by petawatt laser pulses, Phys. Rev. Accel. Beams, 23, (2020), 021302 [3] J. Van Tilborg, et al., Active Plasma Lensing for Relativistic Laser-Plasma-Accelerated Electron Beams, Phys. Rev. Lett., 115, (2015), 184802

Proceedings Article | 28 September 2007 Paper

Radioluminescence and radiation effects in metal organic framework materials

F. P. Doty, C. Bauer, P. Grant, B. Simmons, A. Skulan, M. Allendorf

Proceedings Volume 6707, 67070F (2007) https://doi.org/10.1117/12.740829

KEYWORDS: Micro optical fluidics, Luminescence, Crystals, Metals, Scintillators, Ultraviolet radiation, Molecules, Zinc, Radiation effects, Scintillation

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Proceedings Article | 24 September 2007 Paper

Order and charge collection correlations in organic materials for neutron detection

Tiffany Wilson, F. Doty, Douglas Chinn, Michael King, Blake Simmons

Proceedings Volume 6707, 670710 (2007) https://doi.org/10.1117/12.740660

KEYWORDS: Polymers, FT-IR spectroscopy, Dichroic materials, Organic materials, Infrared radiation, Absorbance, Semiconductors, Polarization, Solid state electronics, Dielectrics

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Proceedings Article | 23 January 2006 Paper

Injection molded microfluidic devices for biological sample separation and detection

Alfredo Morales, Blake Simmons, Thomas Wallow, K. Jeffery Campbell, Seethambal Mani, Brita Mittal, Robert Crocker, Eric Cummings, Rafael Davalos, Linda Domeier, Marion Hunter, Karen Krafcik, Gregory McGraw, Bruce Mosier, Shane Sickafoose

Proceedings Volume 6109, 610901 (2006) https://doi.org/10.1117/12.648135

KEYWORDS: Microfluidics, Particles, Glasses, Polymers, Nickel, Semiconducting wafers, Etching, Dielectrophoresis, Electrodes, Capillaries

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Proceedings Article | 22 January 2005 Paper

Polymeric microfluidic devices for the monitoring and separation of water-borne pathogens utilizing insulative dielectrophoresis

Greg McGraw, Rafael Davalos, John Brazzle, John Hachman, Marion Hunter, Jeffery Chames, Gregory Fiechtner, Eric Cummings, Yolanda Fintschenko, Blake Simmons

Proceedings Volume 5715, (2005) https://doi.org/10.1117/12.597711

KEYWORDS: Polymers, Dielectrophoresis, Particles, Microfluidics, Glasses, Organisms, Bacteria, Electrodes, Pathogens, Nickel

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Proceedings Article | 22 January 2005 Paper

Fabrication and characterization of polymer microfluidic devices for bio-agent detection

Alfredo Morales, John Brazzle, Robert Crocker, Linda Domeier, Eric Goods, John Hachman, Cindy Harnett, Marion Hunter, Seethambal Mani, Bruce Mosier, Blake Simmons

Proceedings Volume 5716, (2005) https://doi.org/10.1117/12.592802

KEYWORDS: Microfluidics, Polymers, Glasses, Nickel, Interferometry, Glass molding, Metrology, Semiconducting wafers, Reliability, Diffusion

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Showing 5 of 6 publications

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