Dr. Brian E. Applegate Profile

Dr. Brian E. Applegate

Professor at Univ of Southern California

SPIE Involvement:

Conference Chair | Author

Publications (52)

Proceedings Article | 21 October 2024 Poster

Development of planar waveguide structure for detecting hearing disorders by optical coherence tomography

Yicheng Ma, Brian Applegate, Tomasz Tkaczyk

Proceedings Volume 13186, 1318613 (2024) https://doi.org/10.1117/12.3034639

KEYWORDS: Optical coherence tomography, Planar waveguides, Diseases and disorders, Waveguides, Two photon polymerization, Imaging systems, 3D printing, Spectroscopy, Miniature imaging systems, Manufacturing

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Proceedings Article | 21 October 2024 Poster

Quantification of the healthy and pathological tympanic membrane with a hand-held optical coherence tomography (HHOCT) device

Marcela Morán, Zihan Yang, Ryan Long, Wihan Kim, John Oghalai, Brian Applegate

Proceedings Volume 13186, 131861M (2024) https://doi.org/10.1117/12.3037160

KEYWORDS: Optical coherence tomography, Ear, Image segmentation, Voxels, Thulium, Pathology, Image processing, Visualization, Video, Stereoscopy

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SPIE Journal Paper | 20 August 2024 Open Access

Optical coherence tomography otoscope for imaging of tympanic membrane and middle ear pathology

Wihan Kim, Ryan Long, Zihan Yang, John Oghalai, Brian Applegate

JBO, Vol. 29, Issue 08, 086005, (August 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.8.086005

KEYWORDS: Optical coherence tomography, Ear, Biomedical optics, Imaging systems, Tissues, Pathology, Video, Diagnostics, Standards development, Volume rendering

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Proceedings Article | 19 June 2024 Presentation

Optical coherence tomography as a tool for interrogating pathologies of the tympanic membrane and middle ear

Marcela Moran, Zihan Yang, Wihan Kim, Ryan Long, John Oghalai, Brian Applegate

Proceedings Volume PC13009, PC1300904 (2024) https://doi.org/10.1117/12.3017301

KEYWORDS: Ear, Optical coherence tomography, Pathology, Vibration, Standards development, Medical imaging, Imaging systems, Image processing, System integration, Scanning probe lithography

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Proceedings Article | 13 March 2024 Presentation + Paper

Analysis of ear symmetry as a diagnostic tool enabled by optical coherence tomography

Zihan Yang, Wihan Kim, Marcela Morán, Ryan Long, John Oghalai, Brian Applegate

Proceedings Volume 12818, 1281802 (2024) https://doi.org/10.1117/12.3003397

KEYWORDS: Ear, Optical coherence tomography, Image registration, 3D image processing, Image processing, Diseases and disorders, Quantitative analysis, Imaging systems, Diagnostics, Matrices

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Proceedings Article | 13 March 2024 Presentation + Paper

Hand-held optical coherence tomography endoscope and stitching algorithm for imaging the human cochlea via the round window

Julianna Bordas, Wihan Kim, Michael Serafino, Jack Tang, Dorothy Pan, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300O (2024) https://doi.org/10.1117/12.3005704

KEYWORDS: Endoscopes, Windows, Ear, Optical coherence tomography, Cochlea, Diseases and disorders, Biological imaging, Detection and tracking algorithms, Algorithm development, X-ray computed tomography

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Proceedings Article | 13 March 2024 Presentation + Paper

Ex-vivo imaging of the human cochlea using 1.7µm SS-OCT

Jack Tang, Dorothy Pan, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300P (2024) https://doi.org/10.1117/12.3005720

KEYWORDS: Optical coherence tomography, Cochlea, Biological imaging, Tissues, Bone, Mach Zehnder interferometers, Photodetectors, Multiple scattering, Microelectromechanical systems, Laser scattering

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Proceedings Article | 13 March 2024 Poster + Paper

Enhancing roll-off performance in SD-OCT with a frequency comb

Regina Magalhaes, Michael Serafino, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300K (2024) https://doi.org/10.1117/12.3005759

KEYWORDS: Frequency combs, Optical coherence tomography, Signal detection, Imaging systems, Ear, Tunable filters, Design, Light sources, Optical isolators, Spectrometers

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Proceedings Article | 13 March 2024 Presentation + Paper

Dynamic optical coherence tomography strongly enhances contrast in the ex vivo murine cochlea

Michael Serafino, Clayton Walker, Patricia Quiñones, Juemei Wang, Frank Macías-Escrivá, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300X (2024) https://doi.org/10.1117/12.3005635

KEYWORDS: Optical coherence tomography, Cochlea, Interferograms, RGB color model, Image quality standards, Anatomy, Visualization, Nerve, Neodymium, In vivo imaging

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Proceedings Article | 13 March 2024 Poster + Paper

Contrast-enhanced optical coherence tomography based on spatial frequency analysis applied to the murine cochlea

Zihan Yang, Wihan Kim, Patricia Quiñones, John Oghalai, Brian Applegate

Proceedings Volume 12830, 128300L (2024) https://doi.org/10.1117/12.3005760

KEYWORDS: Optical coherence tomography, Cochlea, Spatial frequencies, Tissues, Image contrast enhancement, Visualization, Spectral density

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Proceedings Article | 12 March 2024 Presentation + Paper

A 3D-printed reflective lens fabricated via 2-photon polymerization for flexible catheter endoscopy

Clayton Walker, Kevin Beckford, Tomasz Tkaczyk, Brian Applegate

Proceedings Volume 12876, 128760L (2024) https://doi.org/10.1117/12.3017667

KEYWORDS: Endoscopes, Ear, Two photon polymerization, Printing, Fabrication, Optical coherence tomography

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SPIE Journal Paper | 8 August 2023 Open Access

Porcine vocal fold elasticity evaluation using Brillouin spectroscopy

Vsevolod Cheburkanov, Ethan Keene, Jason Pipal, Michael Johns, Brian Applegate, Vladislav Yakovlev

JBO, Vol. 28, Issue 08, 087002, (August 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.8.087002

KEYWORDS: Elasticity, Spectroscopy, Tissues, Imaging spectroscopy, Materials properties, Biological samples, Iodine, Scattering, Acetone, Viscoelasticity

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Proceedings Article | 8 March 2023 Presentation + Paper

Development of a hand-held OCT laryngoscope for reconstruction of 4-D vocal fold dynamics

Anna Wisniowiecki, Wihan Kim, Frank Macias-Escriva, Diego Razura, Michael Johns, Brian Applegate

Proceedings Volume 12367, 1236702 (2023) https://doi.org/10.1117/12.2652767

KEYWORDS: Optical coherence tomography, Reconstruction algorithms, Vibration, Diagnostics, In vivo imaging, Visualization, Algorithm development, Microelectromechanical systems, Endoscopy, Dichroic mirrors

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Proceedings Article | 6 March 2023 Presentation

Development of optical fiber arrays for snapshot imaging spectroscopy and OCT using 2-photon polymerization technique

Haimu Cao, Christopher Flynn, Brian Applegate, Tomasz Tkaczyk

Proceedings Volume PC12372, PC1237207 (2023) https://doi.org/10.1117/12.2651705

KEYWORDS: Two photon polymerization, Optical fibers, Optical coherence tomography, Optical arrays, Imaging spectroscopy, Imaging arrays, Additive manufacturing, Optics manufacturing, Imaging systems, Structured optical fibers

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Proceedings Article | 6 March 2023 Presentation

Fabrication of optical fibers and fiber couplers using 2-photon lithography

Christopher Flynn, Haimu Cao, Brian Applegate, Tomasz Tkaczyk

Proceedings Volume PC12372, PC123720B (2023) https://doi.org/10.1117/12.2652569

KEYWORDS: Fiber couplers, Optical fibers, Lithography, Refractive index, Polymers, Photorefractive polymers, Additive manufacturing, Polymer optical fibers, Optical coherence tomography, Cladding

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Proceedings Article | 7 March 2022 Presentation + Paper

Development of a 3D vibrometry system for vector of motion measurements in the living cochlea

Derek Liu, Wihan Kim, Sangmin Kim, Kumara Ratnayake, Scott Mattison, John Oghalai, Brian Applegate

Proceedings Volume 11948, 1194809 (2022) https://doi.org/10.1117/12.2612280

KEYWORDS: Vibrometry, Optical coherence tomography, Motion measurement, Mechanics, Image registration, Image processing

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Proceedings Article | 7 March 2022 Poster + Paper

Multi-window approach to improve resolution, side-lobe suppression, and phase sensitivity in OCT

Clayton Walker, Anna Wisniowiecki, Jack Tang, John Oghalai, Brian Applegate

Proceedings Volume 11948, 119480P (2022) https://doi.org/10.1117/12.2613301

KEYWORDS: Optical coherence tomography, Phase measurement, Ear, Vibrometry, Interferometry, Fourier transforms, Angiography

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Proceedings Article | 7 March 2022 Presentation

Dual-wavelength excitation multispectral autofluorescence lifetime imaging handheld probe for label-free metabolic clinical imaging of the oral mucosa

Gabriel Tortorelli, Rodrigo Cuenca Martinez, Michael Serafino, Wihan Kim, Brian Applegate, Javier Jo

Proceedings Volume PC11935, PC1193508 (2022) https://doi.org/10.1117/12.2608936

KEYWORDS: Multispectral imaging, Mirrors, Lenses, Tissues, Time resolved spectroscopy, Relays, Objectives, Medicine, Luminescence, Human subjects

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SPIE Journal Paper | 30 September 2020 Open Access

Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging

Xi Chen, Wihan Kim, Michael Serafino, Zheng Tan, Javier Jo, Brian Applegate

JBO, Vol. 25, Issue 09, 096010, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096010

KEYWORDS: Optical coherence tomography, Endoscopes, Fluorescence lifetime imaging, Luminescence, Cladding, Imaging systems, Arteries, Absorption, Silica, Polishing

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Significance: Detailed biochemical and morphological imaging of the plaque burdened coronary arteries holds the promise of improved understanding of atherosclerosis plaque development, ultimately leading to better diagnostics and therapies. Aim: Development of a dual-modality intravascular catheter supporting swept-source optical coherence tomography (OCT) and frequency-domain fluorescence lifetime imaging (FD-FLIM) of endogenous fluorophores with UV excitation. Approach: We instituted a refined approach to endoscope development that combines simulation in a commercial ray tracing program, fabrication, and a measurement method for optimizing ball-lens performance. With this approach, we designed and developed a dual-modality catheter endoscope based on a double-clad fiber supporting OCT through the core and fluorescence collection through the first cladding. We varied the relative percent of UV excitation launched into the core and first cladding to explore the potential resolution improvement for FD-FLIM. The developed catheter endoscope was optically characterized, including measurement of spatial resolution and fluorescent lifetimes of standard fluorophores. Finally, the system was demonstrated on fresh ex vivo human coronary arteries. Results: The developed endoscope was shown to have optical performance similar to predictions derived from the simulation approach. The FLIM resolution can be improved by over a factor of 4 by primarily illuminating through the core rather than the first cladding. However, time-dependent solarization losses need to be considered when choosing the relative percentage. We ultimately chose to illuminate with 7% of the power transmitting through the core. The resulting catheter endoscope had 40-μm lateral resolution for OCT and <100 μm lateral resolution for FD-FLIM. Images of ex vivo coronary arteries are consistent with expectations based on histopathology. Conclusions: The results demonstrate that our approach for endoscope simulation produces reliable predictions of endoscope performance. Simulation results guided our development of a multimodal OCT/FD-FLIM catheter imaging system for investigating atherosclerosis in coronary arteries.

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Proceedings Article | 9 March 2020 Presentation

Optical coherence tomography based Vibrometry as a probe of cochlear mechanics (Conference Presentation)

Brian Applegate

Proceedings Volume 11242, 112420V (2020) https://doi.org/10.1117/12.2552939

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Proceedings Article | 19 July 2019 Paper

Stereo microscope based OCT system capable of subnanometer vibrometry in the middle ear

Wihan Kim, Sangmin Kim, John Oghalai, Brian Applegate

Proceedings Volume 11078, 110780G (2019) https://doi.org/10.1117/12.2527222

KEYWORDS: Optical coherence tomography, Ear, Microscopes, Imaging systems, Vibrometry, Distortion, Diagnostics, Biomedical engineering, Coherence imaging

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Proceedings Article | 15 March 2018 Presentation

Contrast enhancement of pump-probe optical coherence tomography (PP-OCT) based molecular imaging using methylene blue loaded PLGA particles (Conference Presentation)

Jorge Palma-Chavez, Wihan Kim, Brian Applegate, Phapanin Charoenphol, Javier Jo

Proceedings Volume 10508, 105080F (2018) https://doi.org/10.1117/12.2287469

KEYWORDS: Particles, Optical coherence tomography, Molecular imaging, Arteries, Molecules, Light scattering, Chemical vapor deposition, Image resolution, Crystals, Imaging systems

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Proceedings Article | 14 March 2018 Presentation

Automatic detection of macrophages/foam cells in coronary atherosclerotic plaques based on fluorescence lifetime imaging (FLIM) (Conference Presentation)

Jose Rico-Jimenez, Michael Serafino, Xi Chen, Sebina Shrestha, Wihan Kim, Brian Walton, Brian Applegate, Javier Jo

Proceedings Volume 10471, 1047105 (2018) https://doi.org/10.1117/12.2288606

KEYWORDS: Fluorescence lifetime imaging, Multispectral imaging, Foam, Microscopy, Image analysis, Machine learning, Tissues, Receivers, Statistical analysis

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Proceedings Article | 14 March 2018 Presentation

Compact and cost-effective handheld multispectral fluorescence lifetime imaging (FLIM) system for oral mucosa in vivo imaging based on a frequency-domain implementation (Conference Presentation)

Shuna Cheng, Michael Serafino, Rodrigo Cuenca, Beena Ahmed, Brian Applegate, Javier Jo

Proceedings Volume 10469, 104690O (2018) https://doi.org/10.1117/12.2287855

KEYWORDS: Fluorescence lifetime imaging, Imaging systems, In vivo imaging, Lenses, Relays, Signal processing, Multispectral imaging, Endoscopes, Microelectromechanical systems, Scanners

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Proceedings Article | 14 March 2018 Presentation

Design and validation of the ball lens-based intravascular catheter for fluorescence lifetime imaging microscopy of atherosclerosis (Conference Presentation)

Xi Chen, Wihan Kim, Michael Serafino, Zheng Tan, Brian Walton, L. Maximilian Buja, Jessie Adame, Javier Jo, Brian Applegate

Proceedings Volume 10471, 1047102 (2018) https://doi.org/10.1117/12.2287447

KEYWORDS: Fluorescence lifetime imaging, Microscopy, Endoscopes, Luminescence, Endoscopy, Tissues, Fiber optics, Performance modeling, Zemax, Polishing

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Proceedings Article | 25 January 2018 Presentation

Design and validation of the ball lens-based intravascular catheter for fluorescence lifetime imaging microscopy of atherosclerosis (Conference Presentation)

Xi Chen, Wihan Kim, Michael Serafino, Javier Jo, Brian Applegate

Proceedings Volume 9689, 968932 (2018) https://doi.org/10.1117/12.2211764

SPIE Journal Paper | 6 July 2017 Open Access

Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography

George Liu, Jinkyung Kim, Brian Applegate, John Oghalai

JBO, Vol. 22, Issue 07, 076002, (July 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.7.076002

KEYWORDS: In vivo imaging, Optical coherence tomography, Animal model studies, Solid modeling, Ear, Mouse models

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Proceedings Article | 1 May 2017 Presentation

Toward intravascular morphological and biochemical imaging of atherosclerosis with optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIM) (Conference Presentation)

Xi Chen, Wihan Kim, Michael Serafino, Brian Walton, Javier Jo, Brian Applegate

Proceedings Volume 10060, 1006007 (2017) https://doi.org/10.1117/12.2256676

KEYWORDS: Shortwaves, Optical coherence tomography, Fluorescence lifetime imaging, Imaging systems, Endoscopes, Infrared imaging, Lens design, Arteries, Therapeutics, Near ultraviolet

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Proceedings Article | 27 April 2016 Presentation

Use of a highly transparent zebrafish mutant for investigations in the development of the vertebrate auditory system (Conference Presentation)

Anna Wisniowiecki, Scott Mattison, Sangmin Kim, Bruce Riley, Brian Applegate

Proceedings Volume 9716, 97160C (2016) https://doi.org/10.1117/12.2213087

KEYWORDS: Ear, Mechanics, Optical coherence tomography, Image quality, Functional imaging, Bladder, Genetics, Biomedical optics, Biology, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Pump-probe optical coherence tomography using microencapsulated methylene blue as a contrast agent (Conference Presentation)

Wihan Kim, Erin Zebrowski, Hazel Lopez, Brian Applegate, Phapanin Charoenphol, Javier Jo

Proceedings Volume 9697, 969722 (2016) https://doi.org/10.1117/12.2214829

KEYWORDS: Optical coherence tomography, Imaging systems, Molecules, Receptors, Biochemistry, Visualization, In vivo imaging, Molecular lasers, Semiconductor lasers, Mirrors

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SPIE Journal Paper | 27 August 2014 Open Access

Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch

Paritosh Pande, Sebina Shrestha, Jesung Park, Michael Serafino, Irma Gimenez-Conti, Jimi Brandon, Yi-Shing Cheng, Brian Applegate, Javier Jo

JBO, Vol. 19, Issue 08, 086022, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086022

KEYWORDS: Optical coherence tomography, Tissues, Image classification, Image segmentation, Cancer, Feature selection, Image processing, Image analysis, Tumor growth modeling, Imaging systems

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Proceedings Article | 4 March 2013 Paper

Continuous, high-speed, volumetric photoacoustic microscopy via a field programmable gate array

Scott Mattison, Ryan Shelton, Ryan Maxson, Brian Applegate

Proceedings Volume 8581, 85813I (2013) https://doi.org/10.1117/12.2004693

KEYWORDS: Field programmable gate arrays, Demodulation, Clocks, Signal processing, Image processing, Transducers, Photoacoustic microscopy, Heart, Real time imaging, Imaging systems

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Proceedings Article | 29 February 2012 Paper

Combined FLIM and reflectance confocal microscopy for epithelial imaging

Joey Jabbour, Shuna Cheng, Sebina Shrestha, Bilal Malik, Javier Jo, Brian Applegate, Kristen Maitland

Proceedings Volume 8216, 82160A (2012) https://doi.org/10.1117/12.908876

KEYWORDS: Confocal microscopy, Tissues, Reflectivity, Fluorescence lifetime imaging, Cancer, Imaging systems, Image resolution, Collagen, Signal detection, Tissue optics

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Proceedings Article | 28 February 2012 Paper

Multidepth imaging by chromatic dispersion confocal microscopy

Cory Olsovsky, Ryan Shelton, Meagan Saldua, Oscar Carrasco-Zevallos, Brian Applegate, Kristen Maitland

Proceedings Volume 8214, 82140L (2012) https://doi.org/10.1117/12.909175

KEYWORDS: Confocal microscopy, Chromatic aberrations, Dispersion, Point spread functions, Lenses, Spectroscopy, Tissues, In vivo imaging, Objectives, Colorimetry

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Proceedings Article | 23 February 2012 Paper

Time-resolved transient absorption ultrasonic microscopy measurements of the ground state recovery time

Ryan Shelton, Scott Mattison, Brian Applegate

Proceedings Volume 8223, 82233U (2012) https://doi.org/10.1117/12.909415

KEYWORDS: Blood, Chromophores, Absorption, Luminescence, Ultrasonics, Microscopy, Photoacoustic spectroscopy, Multiphoton microscopy, Photoacoustic microscopy, Rhodamine

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Proceedings Article | 18 February 2012 Paper

Quantitative comparison of hardware architectures for high-speed processing in optical coherence tomography

Brian Applegate, Jesung Park, Esteban Carbajal, Darren Schmidt, Kalyanramu Vemishetty

Proceedings Volume 8213, 821332 (2012) https://doi.org/10.1117/12.911755

KEYWORDS: Field programmable gate arrays, Optical coherence tomography, Software development, Computing systems, Data conversion, Computer architecture, Clocks, LabVIEW, Fourier transforms, Data processing

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Proceedings Article | 9 February 2012 Paper

Methodology for assessment of structural vibrations by spectral domain optical coherence tomography

Simon Gao, Patrick Raphael, Anping Xia, Jesung Park, Esteban Carbajal, Brian Applegate, John Oghalai

Proceedings Volume 8207, 82072B (2012) https://doi.org/10.1117/12.920798

KEYWORDS: Optical coherence tomography, Laser Doppler velocimetry, Signal to noise ratio, Cameras, Data processing, MATLAB, Fourier transforms, Diagnostics, Mirrors, Spectroscopy

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Proceedings Article | 30 January 2012 Paper

Measuring the vibrational response of the mouse ear using coherently interleaved optical coherence tomography

Ryan Shelton, Simon Gao, John Oghalai, Brian Applegate

Proceedings Volume 8213, 82131Q (2012) https://doi.org/10.1117/12.911636

KEYWORDS: Ear, Optical coherence tomography, Spectroscopy, Cameras, Algorithm development, Phase shifts, Interferometers, Line scan image sensors, Phase interferometry, Linear filtering

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Proceedings Article | 9 June 2011 Paper

Exploiting chromatic aberration to spectrally encode depth in reflectance confocal microscopy

Oscar Carrasco-Zevallos, Ryan Shelton, Cory Olsovsky, Meagan Saldua, Brian Applegate, Kristen Maitland

Proceedings Volume 8086, 80861D (2011) https://doi.org/10.1117/12.889806

KEYWORDS: Colorimetry, Confocal microscopy, Objectives, Collimation, Chromatic aberrations, Microscopes, Reflectivity, Sapphire lasers, Mirrors, Computer programming

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Proceedings Article | 18 February 2011 Paper

Ultrahigh resolution photoacoustic microscopy via transient absorption

Ryan Shelton, Brian Applegate

Proceedings Volume 7899, 78990S (2011) https://doi.org/10.1117/12.875578

KEYWORDS: Absorption, Spatial resolution, Image resolution, Photoacoustic spectroscopy, Photoacoustic microscopy, Capillaries, Microscopy, Ultrasonics, Transducers, Microscopes

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Proceedings Article | 12 February 2011 Paper

Imaging of the intact mouse cochlea by spectral domain optical coherence tomography

Simon Gao, Tao Yuan, Anping Xia, Patrick Raphael, Ryan Shelton, Brian Applegate, John Oghalai

Proceedings Volume 7889, 788931 (2011) https://doi.org/10.1117/12.875739

KEYWORDS: Optical coherence tomography, Bone, Tissues, Magnetic resonance imaging, Image quality, Image resolution, Visible radiation, Visualization, Neurons, X-ray computed tomography

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Proceedings Article | 24 February 2010 Paper

Off-axis photoacoustic microscopy

Ryan Shelton, Brian Applegate

Proceedings Volume 7564, 756410 (2010) https://doi.org/10.1117/12.841082

KEYWORDS: Transducers, Ultrasonics, Signal detection, Photoacoustic spectroscopy, Microscopes, Photoacoustic microscopy, Tissues, Sensors, Imaging systems, Acoustics

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Proceedings Article | 20 February 2010 Paper

Design of a dual-modality imaging system using optical coherence tomography and fluorescence lifetime imaging microscopy for anatomical and biochemical diagnosis of tissue

Sebina Shrestha, Javier Jo, Jesung Park, Paritosh Pande, Brian Applegate

Proceedings Volume 7554, 75540X (2010) https://doi.org/10.1117/12.843316

KEYWORDS: Optical coherence tomography, Fluorescence lifetime imaging, Tissues, Luminescence, Imaging systems, Cancer, Microscopy, Tissue optics, Arteries, Capillaries

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Proceedings Article | 20 February 2010 Paper

Pump-probe optical coherence microscopy

Qiujie Wan, Brian Applegate

Proceedings Volume 7554, 75541Z (2010) https://doi.org/10.1117/12.843310

KEYWORDS: Optical coherence microscopy, Melanoma, Optical coherence tomography, Tissues, Molecular imaging, Chromophores, Skin, Optical filters, Biomedical optics, Beam splitters

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Proceedings Article | 12 February 2010 Paper

Multimodality optical imaging combining optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIM) for morphological and biochemical tissue characterization

Sebina Shrestha, Jesung Park, Paritosh Pande, Brian Applegate, Javier Jo

Proceedings Volume 7561, 75610N (2010) https://doi.org/10.1117/12.841421

KEYWORDS: Optical coherence tomography, Fluorescence lifetime imaging, Luminescence, Tissues, Mirrors, Tissue optics, Capillaries, Optical imaging, Imaging systems, Signal detection

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Proceedings Article | 18 February 2008 Paper

Fourier domain pump-probe optical coherence tomography: hemoglobin imaging at 830 nm

Brian Applegate, Desmond Jacob, Joseph Izatt

Proceedings Volume 6847, 68471A (2008) https://doi.org/10.1117/12.766839

KEYWORDS: Optical coherence tomography, Absorption, Scattering, Light scattering, Tissue optics, Imaging systems, Coherence imaging, Blood oxygen saturation, Signal to noise ratio, Arteries

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SPIE Journal Paper | 1 July 2007 Open Access

Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells

Emily McDowell, Audrey Ellerbee, Michael Choma, Brian Applegate, Joseph Izatt

JBO, Vol. 12, Issue 04, 044008, (July 2007) https://doi.org/10.1117/12.10.1117/1.2753755

KEYWORDS: Data modeling, Magnetism, Microscopy, Cytoskeletons, Reflectors, Reflection, Interferometry, Optical coherence tomography, Interfaces, Motion models

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Proceedings Article | 7 February 2007 Paper

Molecular imaging of hemoglobin using ground state recovery pump-probe optical coherence tomography

Brian Applegate, Joseph Izatt

Proceedings Volume 6429, 64291Y (2007) https://doi.org/10.1117/12.703272

KEYWORDS: Optical coherence tomography, Chromophores, Blood, Signal processing, Spatial resolution, Absorption, Tissue optics, Blood oxygen saturation, Molecular imaging, Blood vessels

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Proceedings Article | 20 February 2006 Paper

Full-field swept-source phase microscopy

Marinko Sarunic, Seth Weinberg, Audrey Ellerbee, Brian Applegate, Joseph Izatt

Proceedings Volume 6079, 60791X (2006) https://doi.org/10.1117/12.649206

KEYWORDS: Optical coherence tomography, Microscopy, Signal to noise ratio, Image resolution, Interferometers, Imaging systems, Charge-coupled devices, Fourier transforms, Glasses, Microscopes

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Proceedings Article | 15 February 2006 Paper

Transient absorption and lifetime imaging with ground state recovery pump-probe optical coherence tomography

Brian Applegate, Joseph Izatt

Proceedings Volume 6079, 607902 (2006) https://doi.org/10.1117/12.649111

KEYWORDS: Optical coherence tomography, Chromophores, Absorption, Rhodamine, Luminescence, Molecules, Blood, Beam splitters, Molecular biology, Tissues

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Proceedings Article | 13 April 2005 Paper

Molecular contrast optical coherence tomography: SNR comparison of techniques and introduction of ground state recovery pump-probe OCT

Brian Applegate, Marinko Sarunic, Changhuei Yang, Joseph Izatt

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592866

KEYWORDS: Signal to noise ratio, Optical coherence tomography, Rhodamine, Spectroscopy, Absorption, Molecules, Signal detection, Luminescence, Quantum efficiency, Molecular spectroscopy

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Proceedings Article | 30 March 2005 Paper

Spectral domain second harmonic optical coherence tomography

Marinko Sarunic, Brian Applegate, Joseph Izatt

Proceedings Volume 5700, (2005) https://doi.org/10.1117/12.592766

KEYWORDS: Optical coherence tomography, Signal to noise ratio, Sensors, Harmonic generation, Spectrometers, Signal detection, Collagen, Bone, Crystals, Gallium arsenide

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