Mr. Christian Kier Profile

Christian Kier

at Univ Luebeck

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Proceedings Article | 12 April 2005 Paper

Cerebral perfusion imaging with bolus harmonic imaging

Christian Kier, Daniel Toth, Karsten Meyer-Wiethe, Angela Schindler, Hakan Cangur, Gunter Seidel, Til Aach

Proceedings Volume 5750, (2005) https://doi.org/10.1117/12.592681

KEYWORDS: Ultrasonography, Tissues, Targeting Task Performance metric, Brain, Diagnostics, Signal to noise ratio, Neuroimaging, Ischemic stroke, Visualization, Image visualization

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Fast visualisation of cerebral microcirculation supports diagnosis of acute stroke. However, the commonly used CT/MRI-based methods are time consuming, costly and not applicable to every patient. The bolus perfusion harmonic imaging (BHI) method is an ultrasound imaging technique which makes use of the fact, that ultrasound contrast agents unlike biological tissues resonate at harmonic frequencies. Exploiting this effect, the contrast between perfused and non-perfused areas can be improved. Thus, BHI overcomes the low signal-to-noise ratio of transcranial ultrasound and the high impedance of the skull. By analysing image sequences, visualising the qualitative characteristics of an US contrast agent bolus injection becomes possible. The analysis consists of calculating four perfusion-related parameters, Local Peak Intensity, Time To Peak, Area Under Curve, and Average Rising, from the time/intensity curve and providing them as colour-coded images. For calculating these parameters the fundamental assumption is that image intensity corresponds to contrast agent concentration which in turn shows the perfusion of the corresponding brain region. In a clinical study on patients suffering from acute ischemic stroke it is shown that some of the parameters correlate significantly to the infarction area. Thus, BHI becomes a less time-consuming and inexpensive bedside method for diagnosis of cerebral perfusion deficits.

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