Unspecified Davide Tamborini Profile

Davide Tamborini

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Publications (19)

SPIE Journal Paper | 17 February 2022 Open Access

Erratum: Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling

Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Joyce Chu, Maria Angela Franceschini, Jason Qu, Stefan Carp

NPh, Vol. 9, Issue 01, 019801, (February 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.1.019801

KEYWORDS: Physiology, Monte Carlo methods, Cerebral blood flow, Neurophotonics, Biomedical optics, Radiology, Radio optics, Medicine

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SPIE Journal Paper | 12 August 2021 Open Access

Optimization of time domain diffuse correlation spectroscopy parameters for measuring brain blood flow

Dibbyan Mazumder, Melissa Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, Stefan Carp

NPh, Vol. 8, Issue 03, 035005, (August 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.3.035005

KEYWORDS: Photons, Monte Carlo methods, Picosecond phenomena, Sensors, Head, Tissue optics, Spectroscopy, Brain, Blood circulation, Neurophotonics

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Significance: Time domain diffuse correlation spectroscopy (TD-DCS) can offer increased sensitivity to cerebral hemodynamics and reduced contamination from extracerebral layers by differentiating photons based on their travel time in tissue. We have developed rigorous simulation and evaluation procedures to determine the optimal time gate parameters for monitoring cerebral perfusion considering instrumentation characteristics and realistic measurement noise. Aim: We simulate TD-DCS cerebral perfusion monitoring performance for different instrument response functions (IRFs) in the presence of realistic experimental noise and evaluate metrics of sensitivity to brain blood flow, signal-to-noise ratio (SNR), and ability to reject the influence of extracerebral blood flow across a variety of time gates to determine optimal operating parameters. Approach: Light propagation was modeled on an MRI-derived human head geometry using Monte Carlo simulations for 765- and 1064-nm excitation wavelengths. We use a virtual probe with a source–detector separation of 1 cm placed in the pre-frontal region. Performance metrics described above were evaluated to determine optimal time gate(s) for different IRFs. Validation of simulation noise estimates was done with experiments conducted on an intralipid-based liquid phantom. Results: We find that TD-DCS performance strongly depends on the system IRF. Among Gaussian pulse shapes, ∼300 ps pulse length appears to offer the best performance, at wide gates (500 ps and larger) with start times 400 and 600 ps after the peak of the TPSF at 765 and 1064 nm, respectively, for a 1-s integration time at photon detection rates seen experimentally (600 kcps at 765 nm and 4 Mcps at 1064 nm). Conclusions: Our work shows that optimal time gates satisfy competing requirements for sufficient sensitivity and sufficient SNR. The achievable performance is further impacted by system IRF with ∼300 ps quasi-Gaussian pulse obtained using electro-optic laser shaping providing the best results.

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Proceedings Article | 5 March 2021 Presentation

Characterization of cerebral blood flow quantification with diffuse correlation spectroscopy in the presence of systemic physiology cross-talk during a hypercapnic challenge

Stefan Carp, Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Yawei Chu, Jason Qu, Maria Franceschini

Proceedings Volume 11629, 116291E (2021) https://doi.org/10.1117/12.2579027

KEYWORDS: Cerebral blood flow, Spectroscopy, Physiology, Tissue optics, Carbon dioxide, Ultrasonography, Tissues, Skin, Optical testing, Monte Carlo methods

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Proceedings Article | 5 March 2021 Presentation

Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow

Dibbyan Mazumder, Melissa Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, Stefan Carp

Proceedings Volume 11641, 116410F (2021) https://doi.org/10.1117/12.2577787

KEYWORDS: Monte Carlo methods, Blood circulation, Spectroscopy, Brain, Tissue optics, Tissues, Geometrical optics, Photons, Optical simulations, Motion measurement

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SPIE Journal Paper | 1 January 2021 Open Access

Improved accuracy of cerebral blood flow quantification in the presence of systemic physiology cross-talk using multi-layer Monte Carlo modeling

Melissa Wu, Suk-Tak Chan, Dibbyan Mazumder, Davide Tamborini, Kimberly Stephens, Bin Deng, Parya Farzam, Joyce Yawei Chu, Maria Angela Franceschini, Jason Qu, Stefan Carp

NPh, Vol. 8, Issue 01, 015001, (January 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015001

KEYWORDS: Monte Carlo methods, Modulation, Brain, Physiology, Cerebral blood flow, Skull, Scattering, Carbon monoxide, Blood circulation, Data modeling

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SPIE Journal Paper | 29 September 2020 Open Access

Diffuse correlation spectroscopy measurements of blood flow using 1064 nm light

Stefan Carp, Davide Tamborini, Dibbyan Mazumder, Kuan-Cheng Wu, Mitchell Robinson, Kimberly Stephens, Oleg Shatrovoy, Niyom Lue, Nisan Ozana, Megan Blackwell, Maria Angela Franceschini

JBO, Vol. 25, Issue 09, 097003, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.097003

KEYWORDS: Blood circulation, Absorption, Scattering, Signal to noise ratio, Tissue optics, Near infrared spectroscopy, Spectroscopy, Tissues, Signal attenuation, Sensors

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Proceedings Article | 20 April 2020 Presentation

Overlapping volumes, acousto-optic modulated diffuse correlation spectroscopy for increased depth sensitivity (Conference Presentation)

Mitchell Robinson, Stefan Carp, Sava Sakadzic, Adriano Peruch, Davide Tamborini, Maria Angela Franceschini

Proceedings Volume 11240, 112402T (2020) https://doi.org/10.1117/12.2546630

KEYWORDS: Modulation, Spectroscopy, Acousto-optics, Ultrasonography, Blood circulation, Tissue optics, Brain, Transducers, Speckle, Skull

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Proceedings Article | 10 March 2020 Presentation

Multi-element interferometric diffuse correlation spectroscopy at 1064 nm (Conference Presentation)

Mitchell Robinson, Davide Tamborini, Adriano Peruch, Stefan Carp, Maria Angela Franceschini

Proceedings Volume 11253, 112530I (2020) https://doi.org/10.1117/12.2546350

KEYWORDS: Interferometry, Multi-element lenses, Spectroscopy, Signal detection, Blood circulation, Single photon detectors, Sensors, Brain, Interferometers, Tissue optics

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Proceedings Article | 9 March 2020 Presentation

Simulation of time domain diffuse correlation spectroscopy (TD-DCS) performance for measuring brain blood flow in the presence of noise with realistic sources and detectors (Conference Presentation)

Dibbyan Mazumder, Davide Tamborini, Melissa Wu, Maria Franceschini, Stefan Carp

Proceedings Volume 11239, 112390G (2020) https://doi.org/10.1117/12.2544365

KEYWORDS: Blood circulation, Brain, Spectroscopy, Sensors, Tissue optics, Tissues, Motion measurement, Blood, Cerebral blood flow, Contamination

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Proceedings Article | 9 March 2020 Presentation

Model impact in resolving DCS CBF measurements from systemic variations in blood flow (Conference Presentation)

Melissa Wu, Davide Tamborini, Kimberly Stephens, Dibbyan Mazumder, Parya Farzam, Suk-Tak Chan, Jason Qu, Maria Franceschini, Stefan Carp

Proceedings Volume 11226, 112260X (2020) https://doi.org/10.1117/12.2546699

KEYWORDS: Blood circulation, Natural surfaces, Tissue optics, Magnetic resonance imaging, Monte Carlo methods, Data modeling, Performance modeling, Spectroscopy, Brain, Cerebral blood flow

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Proceedings Article | 9 March 2020 Presentation

Novel detector solutions for diffuse correlation spectroscopy at 1064 nm (Conference Presentation)

Megan Blackwell, Robert Berger, George Jordy, Jonathan Frechette, Brian Aull, Erik Duerr, Mitchell Robinson, Davide Tamborini, Stefan Carp, Maria Angela Franceschini

Proceedings Volume 11239, 112390E (2020) https://doi.org/10.1117/12.2545178

KEYWORDS: Sensors, Spectroscopy, Photodetectors, Signal to noise ratio, Single photon detectors, Readout integrated circuits, Integrated circuit design, Quenching (fluorescence), Computer simulations, Performance modeling

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Proceedings Article | 4 March 2019 Presentation

Connecting theory to the signal dynamics of interferometric diffuse correlation spectroscopy (Conference Presentation)

Mitchell Robinson, Stefan Carp, Davide Tamborini, David Boas, Maria Angela Franceschini

Proceedings Volume 10864, 108640E (2019) https://doi.org/10.1117/12.2510153

KEYWORDS: Spectroscopy, Interferometry, Sensors, Signal detection, Detection theory, Photon counting, Particles, Tissues, Signal attenuation, Single mode fibers

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SPIE Journal Paper | 21 September 2017 Open Access

Development and characterization of a multidistance and multiwavelength diffuse correlation spectroscopy system

Davide Tamborini, Parisa Farzam, Bernhard Zimmermann, Kuan-Cheng Wu, David A. Boas, Maria Angela Franceschini

NPh, Vol. 5, Issue 01, 011015, (September 2017) https://doi.org/10.1117/12.10.1117/1.NPh.5.1.011015

KEYWORDS: Scattering, Sensors, Absorption, Tissue optics, Blood circulation, Optical fibers, Optical properties, Signal to noise ratio, Optical correlators, Tissues

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Proceedings Article | 19 April 2017 Presentation

Fast diffuse correlation spectroscopy (DCS) for non-invasive measurement of intracranial pressure (ICP) (Conference Presentation)

Parisa Farzam, Jason Sutin, Kuan-Cheng Wu, Bernhard Zimmermann, Davide Tamborini, Jay Dubb, David Boas, Maria Angela Franceschini

Proceedings Volume 10050, 100500U (2017) https://doi.org/10.1117/12.2252824

KEYWORDS: Standards development, Spectroscopy, Cerebral blood flow, Blood circulation, Injuries, Transducers, Tissues, Brain, Doppler effect, Ultrasonography

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Proceedings Article | 20 October 2015 Paper

ALART: a novel lidar system for vegetation height retrieval from space

P. Foglia Manzillo, C. van Dijk, S. Conticello, M. Esposito, R. Lussana, F. Villa, D. Tamborini, F. Zappa, A. Tosi, A. Roncat, N. Pfeiffer, T. Entner, D. Lampridis

Proceedings Volume 9645, 96450E (2015) https://doi.org/10.1117/12.2196134

KEYWORDS: Sensors, LIDAR, Vegetation, Aerospace engineering, Photons, Electronics, Receivers, Pulsed laser operation, Space operations, Single photon

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Proceedings Article | 13 March 2015 Paper

Time-to-digital converter card for multichannel time-resolved single-photon counting applications

Davide Tamborini, Davide Portaluppi, Simone Tisa, Alberto Tosi

Proceedings Volume 9369, 93690Q (2015) https://doi.org/10.1117/12.2079740

KEYWORDS: Picosecond phenomena, Time metrology, Clocks, Connectors, Fluorescence lifetime imaging, Positron emission tomography, Fluorescence correlation spectroscopy, Signal detection, Electronics, Shape memory alloys

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Proceedings Article | 28 May 2014 Paper

Low-noise CMOS SPAD arrays with in-pixel time-to-digital converters

Alberto Tosi, Federica Villa, Danilo Bronzi, Yu Zou, Rudi Lussana, Davide Tamborini, Simone Tisa, Daniel Durini, Sascha Weyers, Uwe Pashen, Werner Brockherde, Franco Zappa

Proceedings Volume 9114, 91140C (2014) https://doi.org/10.1117/12.2053415

KEYWORDS: Picosecond phenomena, Clocks, Cameras, Photodetectors, Ranging, Sensors, Imaging systems, Electronics, CMOS technology, Photon counting

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Proceedings Article | 31 January 2014 Paper

Time-resolved optical spectrometer based on a monolithic array of high-precision TDCs and SPADs

Davide Tamborini, Bojan Markovic, Laura Di Sieno, Davide Contini, Andrea Bassi, Simone Tisa, Alberto Tosi, Franco Zappa

Proceedings Volume 8993, 89932I (2014) https://doi.org/10.1117/12.2040519

KEYWORDS: Spectroscopy, Picosecond phenomena, Clocks, Luminescence, Electronics, Field programmable gate arrays, Monochromators, Power supplies, Signal detection, Avalanche photodiodes

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Proceedings Article | 4 February 2013 Paper

Monolithic time-to-digital converter chips for time-correlated single-photon counting and fluorescence lifetime measurements

Bojan Markovic, Davide Tamborini, Simone Bellisai, Andrea Bassi, Antonio Pifferi, Federica Villa, Giorgio Padovini, Alberto Tosi

Proceedings Volume 8631, 86311F (2013) https://doi.org/10.1117/12.2005537

KEYWORDS: Picosecond phenomena, Luminescence, Clocks, Field programmable gate arrays, Electronics, Power supplies, Fluorescence lifetime imaging, Time metrology, Interfaces, Data acquisition

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Showing 5 of 19 publications

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