Lung transplantation is the last therapy option for patients with advanced lung diseases but the shortage of donor lungs currently is a large challenge. We used a polarization-sensitive optical coherence tomography (PS-OCT) system to obtain the distribution and quantification of alveolus and fibrous tissues. Our results showed that the distribution of alveolus and fibrosis was various at different locations on the lung. PS-OCT was able to provide effective quantifications of the alveolus density and size, and the fibrous tissues verified by the histology results. PS-OCT could serve as a promising tool for assessing the quality of donor lungs.
Kidney transplantation faces a worldwide shortage due to the lack of reliable assessment for screening qualified donor kidneys for transplantation. We evaluated the feasibility of using polarization-sensitive optical coherence tomography (PS-OCT) to provide a score map covering the entire surface of a kidney to evaluate the pre-transplantation kidney quality. Multiple histology staining and two-photon microscopy (TPM) were used to provide verification standards for microstructures, tissue distributions, and fibrosis in PS-OCT imaging. Our results indicated that PS-OCT was a reliable method for noninvasively imaging kidney microstructure and fibrosis matching the pretransplant scoring system for assessing the quality of pre-transplantation kidneys.
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