Changes of concentrations of plasma free amino acids (PFAAs) is an essential feature of protein metabolic abnormalities in cancer patients. In this study, we aim to decompose Raman spectra of mixtures of amino acids. The effect of noise on the decomposition result is investigated. The experimentally measured spectra of amino acids and artificially simulated spectra of their mixtures are studied. As a decomposition method, Multivariate Curve Resolution–Alternating Least Squares (MCR-ALS) analysis is used. It is shown that one can evaluate the concentration of amino acids in the mixtures using the Raman spectra of the mixtures and the spectra of pure amino acids. The results can be used in further research on lung cancer.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.