Dr. Eugene Dempsey Profile

Dr. Eugene Dempsey

at Cork Univ Maternity Hospital

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Author

Publications (3)

Proceedings Article | 6 March 2023 Presentation

GASMAS for the non-invasive monitoring of oxygen gas in healthy neonates

Sri Rama Pranav Kumar Lanka, Jurate Panaviene, Konstantin Grygoryev, Sanathana Konugolu Venkata Sekar, Eugene Dempsey, Stefan Anderresson-Engels

Proceedings Volume PC12368, PC123680N (2023) https://doi.org/10.1117/12.2651130

KEYWORDS: Oxygen, Lung, Scattering media, Chest, Absorption spectroscopy

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Proceedings Article | 20 November 2019 Paper

Simulation of near-infrared light propagation through the thorax of a neonate: addressing the optimisation of source and detector positions for measuring lung oxygen content in preterm infants

Andrea Pacheco, Emilie Krite Svanberg, Eugene Dempsey, Stefan Andersson-Engels

Proceedings Volume 11190, 111901C (2019) https://doi.org/10.1117/12.2537875

KEYWORDS: Lung, Sensors, Light, Oxygen, Absorption, Image segmentation, 3D modeling, Light sources, Tissue optics, Skin

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Gas in scattering media absorption spectroscopy shortly called GASMAS, is a tunable diode laser spectroscopic technique developed for the measurement of gas present in turbid media. The technique relies on the sharp and specific absorption lines of gases which enables sensitive measurements of gas concentrations in the presence of a scattering solid medium with much broader absorption features. The Biophotonics laboratory at Tyndall National Institute (Biophotonics@Tyndall) is currently exploring the clinical translation of GASMAS technology into the respiratory healthcare of neonates. In this study, we use computational tools to assess the potential gain in gas absorption signal. One of the challenges in the development of the GASMAS technique is to obtain a sufficiently good signal in the measurements, as the light attenuation is high in tissue and the lungs are interior organs. To have an estimation of the capabilities and limitations in this specific application of gas spectroscopy, we model the transmission of near infrared (NIR) light in tissue when a 760 nm source and a set of 68 detectors are placed in different locations over the thorax. We segmented the main organs of the thorax from anonymized DICOM images of a neonate. This is followed by the creation of 3D computational models to solve light propagation with the diffusion equation, and the modelling of light propagation through the thorax of an infant including optical properties of lung, heart, arteries, bone, muscle, trachea, fat and skin. Finally, we calculate a map of the optimal light source – detector configurations to obtain the highest signal from oxygen gas imprint in the lungs. The use of computational tools such as NIRFAST Slicer 2.0 for investigation and further understanding of the advantages and limitations of the technology is fundamental.

Such simulations enable the recreation of different clinical scenarios and identification of the minimum requirements necessary to further improve the application and develop a bedside clinical device that can potentially be used for continuous monitoring of lung function and control of ventilator settings. The potential capability of measuring non-invasively oxygen, water vapour and carbon dioxide in the lungs, would reduce the need for intubation and extracorporeal membrane oxygenation, as well as lower the incidences of chronic lung disease.

Proceedings Article | 4 March 2019 Presentation + Paper

Oxygen gas concentration measurements in the lungs of neonate chest phantom with realistic geometry and tissue optical properties using diode laser spectroscopy

Andrea Pacheco, Pierluigi Martella, Haiyang Li, Monisha Chakravarty, Eugene Dempsey, Stefan Andersson-Engels

Proceedings Volume 10890, 108900J (2019) https://doi.org/10.1117/12.2507977

KEYWORDS: Lung, Oxygen, Optical properties, Image segmentation, Heart, Absorption, Tissues, 3D modeling, Bone, Silicon

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