Molecular self-assembly, a part of bottom-up self-assembly approach, inspires the construction of challenging molecular topologies. Advances in attosecond sciences lead a wealth of important discoveries in biochemical molecular ultrafast dynamic processes relevant to a single atomic, molecular etc. quantum state toward the generation and application of extreme-ultraviolet (EUV) sub-femtosecond approaches, which offer opportunities to probe challenging molecular topologies. Measurement and control of space-time biophoton-bioelectron coupling dynamic motion in complex biochemical molecular structures-inspired heterosingle quantum state systems are a formidable challenge. Different from infrared van der Waals nanostructures and Borromean rings with three macrocycle interlocked architectures, blue- shift complex structure nanomedicine crystals containing heterosingle molecules, heterosingle atoms, single biophotons, single bioelectrons relied up a directed design according to at least four factor or more factor orthogonal mathematics statistics coupling a bottom-up self-assembly approach wherein inter-molecular self-assembly and intra-molecular self- assembly relied up short range forces like hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interaction, electrostatic interaction, folding mechanisms and long range forces like electromagnetic interactions were involved. By application of self-assembled nanomedicine crystals and self-assembled sub-femtosecond EUV laser micro-photoluminescence (PL) spectroscopy system with third harmonic generator etc. tools, time-resolution blue-shifted laser micro-PL spectroscopy from the near infrared to the ultraviolet was detected and revealed by a sphere integrator. It is concluded that molecular self-assembly-inspired nanomedicine crystal as a testing model paves a way toward facilitating attosecond nanobiophotonic approaches at the single molecular level that is below the diffraction limit of light, which facilitates state-of-the art transformational and translational technologies.
Precision sensing needs to overcome a gap of a single atomic step height standard. In response to the cutting-edge challenge, a heterosingle molecular nanomedicine crystal was developed wherein a nanomedicine crystal height less than 1 nm was designed and selfassembled on a substrate of either a highly ordered and freshly separated graphite or a N-doped silicon with hydrogen bonding by a home-made hybrid system of interacting single bioelectron donor-acceptor and a single biophoton donor-acceptor according to orthogonal mathematical optimization scheme, and an atomic spatial resolution conducting atomic force microscopy (C-AFM) with MHz signal processing by a special transformation of an atomic force microscopy (AFM) and a scanning tunneling microscopy (STM) were employed, wherein a z axis direction UV-VIS laser interferometer and a feedback circuit were used to achieve the minimized uncertainty of a micro-regional structure height and its corresponding local differential conductance quantization (spin state) process was repeatedly measured with a highly time resolution, as well as a pulsed UV-VIS laser micro-photoluminescence (PL) spectrum with a single photon resolution was set up by traceable quantum sensing and metrology relied up a quantum electrical triangle principle. The coupling of a single bioelectron conducting, a single biophoton photoluminescence, a frequency domain temporal spin phase in nanomedicine crystal-inspired sensing methods and sensor technologies were revealed by a combination of C-AFM and PL measurement data-based mathematic analyses1-3, as depicted in Figure 1 and repeated in nanomedicine crystals with a single atomic height. It is concluded that height-current-phase uncertainty correlation pave a way to develop a brain imaging and a single atomic height standard, quantum sensing, national security, worldwide impact1-3 technology and beyond.
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