A flexible software tool was developed that combines predictive models for detector noise and blur with image
simulation and an improved human observer model to predict the clinical task performance of existing and future
radiographic systems. The model starts with high-fidelity images from a database and mathematical models of common
disease features, which may be added to the images at desired contrast levels. These images are processed through the
entire imaging chain including capture, the detector, image processing, and hardcopy or softcopy display. The simulated
images and the viewing conditions are passed to a human observer model, which calculates the detectability index d' of
the signal (disease or target feature). The visual model incorporates a channelized Hotelling observer with a luminance-dependent
contrast sensitivity function and two types of internal visual system noise (intrinsic and image background-induced).
It was optimized based on three independent human observer studies of target detection, and is able to predict
d' over a wide range of viewing conditions, background complexities, and target spatial frequency content. A more
intuitive metric of system performance, Task-Specific Detective Efficiency (TSDE), is defined to indicate how much
detector improvements would translate to better radiologist performance. The TSDE is calculated as the squared ratio of
d' for a system with the actual detector and a hypothetical system containing an ideal detector. A low TSDE, e.g., 5% for
the detection of 0.1 mm microcalcifications in typical mammography systems, indicates that improvements in the
detector characteristics are likely to translate to better detection performance. The TSDE of lung nodule detection is as
high as 75% even with the detective quantum efficiency (DQE) of the detector not exceeding 24%. Applications of the
model to system optimizations for flat-panel detectors, in mammography and dual energy digital radiography, are
discussed.
A compact monochromatic imaging system was designed with an optimal combination of a low power molybdenum source, collimating optic and monochromatizing crystal. The microfocus source was characterized for spot size, source depth, source intensity and source uniformity. Two different polycapillary collimating optics were characterized for collecting radiation from the low power divergent source and redirecting it into a parallel beam. The focal distance, transmission with respect to energy, output uniformity and exit angle divergence were measured. Monochromatization was then achieved by diffraction from a variety of single crystals. For each crystal, the rocking curve width was measured. To predict the actual resolution for the monochromatic imaging, a theoretical 3-dimension resolution calculation was developed. The measured angular resolutions for the horizontal and vertical directions were slightly different and were in good agreement with theoretical values. The measured and theoretical intensity after monochromator crystals showed the expected trade-off between high intensity and high resolution.
Polycapillary optics can be employed as efficient low pass devices in conjunction with simple absorption filters to produce narrow band radiation from conventional broadband x-ray tube sources. Narrow band filtration has been shown to be adequate for low-resolution protein crystallography without a monochromator and for investigating energy-dependent phenomena such as Compton scatter production. For applications that would benefit from more monochromatic or more parallel input beams, polycapillary collimating optics can be used to collect divergent radiation and redirect it towards a monochromatizing crystal to produce orders of magnitude higher diffracted intensity than from pinhole collimation. The implementation of high contrast monochromatic and refractive index imaging with a very low power source has been demonstrated. Polycapillary optics can also be used to provide spatial resolution for inherently monochromatic applications such as microfluorescence and radioscintigraphy.
Polycapillary x-ray optics provide an innovative new way to control x-ray beams. Placing these optics after the object to be imaged provides very efficient rejection of Compton scatter, while allowing image magnification without loss of resolution, image demagnification, or image shaping to match with digital detectors. An extensive study of the effects of surface and profile defects have greatly enhanced the understanding of the manufacturing process and lead to improved reproducibility and manufacturability of the optics. Measurements were performed on magnifying tapers. The optics had measured primary transmissions greater than 50% and scatter transmission of less than 1%. For a 5-cm thick Lucite phantom, this resulted in a contrast enhancement compared to a conventional grid of nearly a factor of two. The magnification from the tapered capillary optics improved the MTF at all frequencies out to 1.9 times the original system resolution. Increases below the system resolution are most important because clinically relevant structures generally occupy lower spatial frequencies. Alternatively, placing a collimating optic and diffracting crystal before the patient provides sufficient monochromatic beam intensity for medical imaging. Contrast, resolution, and intensity measurements were performed with both high and low angular acceptance crystals. At 8 keV, contrast enhancement was a factor of 5 relative to the polychromatic case, in good agreement with theoretical values. At 17.5 keV, monochromatic subject contrast was more than a factor of 2 times greater than the conventional polychromatic contrast. An additional factor of two increase in contrast is expected from the removal of scatter obtained from using the air gap which is allowable from the parallel beam. The measured angular resolution after the crystal was 0.4 mrad for a silicon crystal. The realization of these applications has been advanced by the recent marked improvement in available optic quality and reproducibility. Manufacturing progress has been assisted by the development of simulation analyses which allow for increasingly accurate assessment of optics defects. Optics performance over the whole range of energy from 10 to 80 keV can often be matched with one or two fitting parameters. Continuing optics manufacturing challenges include the advance of applications at energies above 40 keV and the production of optics for imaging which are of adequate clinical size. Multioptic jigs designed to increase imaging area have been tested.
Monochromatic parallel beam imaging produces high subject contrast, high resolution, and low patient dose. Polycapillary collimating optics can be used to create a beam of sufficient intensity for monochromatization from a conventional source. Monochromatization is achieved by diffraction from a single crystal. Contrast, resolution, and intensity measurements were performed with both high and low angular acceptance crystals. Testing was first done at 8 keV with an intense copper rotating anode, then preliminary 17.5 keV measurements were made with a low power molybdenum source. At 8 keV, contrast enhancement was a factor of 5 relative to the polychromatic case, in good agreement with theoretical values. At 17.5 keV, monochromatic subject contrast is a factor of 2 times greater than the conventional polychromatic contrast. An additional factor of two increase in contrast is expected from the removal of scatter obtained from using the air gap which is allowable from the parallel beam. The measured angular resolution after the crystal was 0.6 mrad for a silicon crystal. The use of polycapillary collimating optics allowed monochromatic imaging measurements using a conventional rotating anode source and computed radiography plate in 300 mAs.
Polycapillary x-ray optics can be used as pre- or post-patient optics to design mammographic imaging systems with higher resolution, greater contrast, and a lower absorbed patient dose. A multi-fiber collimating prototype optic, used as pre-patient beam shaper, provides 39% transmission efficiency at 17.5 keV, good uniformity, and only 3.9 mrad divergence. Experimental optics characterization results are compared with detailed computer simulations including analysis of optical defects such as channel waviness and bending. The collimating optic was used to produce monochromatic radiation by diffracting from a silicon crystal. The monochromatic contrast, measured at 8 keV with a polypropylene phantom, was 5 times greater than the measured polychromatic contrast.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.