Biodetection instrumentation that is capable of functioning effectively outside the controlled laboratory environment is
critical for the detection of health threats, and is a crucial technology for Health Security. Experience in bringing
technologies from the basic research laboratory to integrated fieldable instruments suggests lessons for the engineering
of these systems. This overview will cover several classes of such devices, with examples from systems developed for
homeland security missions by Lawrence Livermore National Laboratory (LLNL). Recent trends suggest that front-end
sample processing is becoming a critical performance-determining factor for many classes of fieldable biodetection
devices. This paper introduces some results of a recent study that was undertaken to assess the requirements and
potential technologies for next-generation integrated sample processing.
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