The biosensor is extremely important for the early diagnosis, drug discovery, healthcare, and clinical applications. Here we propose a unique LPG/FBG hybrid structure yielding ultra-narrow and high signal-to-noise ratio reflection resonances. It is the first time to report high order cladding-cladding mode coupling beyond core-core and core-cladding coupling. The proposed device has been exploited as optical biosensor for the detection of human haemoglobin achieving a high sensitivity. The proposed sensor can be further developed as a point-of-care device for portable and label-free biomedical diagnostic applications.
In this work, we propose a miniature and high-performance MXene-based fibre optic Fabry-Perot Interferometer (FPI) for the detection of heavy metal (mercury) in the water. Light from fibre tips (FP cavity) induce interference through partial reflection at interfaces. The systematic investigations have been conducted for the free spectral range against the FP cavity length, the effect of finesse on the surface reflectance of FP cavity surface using thin film gold-coated fibre tips of various thickness in nanometre scales. The FP fibre tip deposited with MXene nanolayer will be developed to detect Hg2+ in water by inducing a strong response through the adsorption and reduction of Hg2+ to Hg+ with MXene nanomaterials. The nanomaterial integrated FPI sensing scheme could be an alternative for food, water quality, and environmental monitoring.
KEYWORDS: Breast cancer, Cancer detection, Biosensors, Graphene, Optical surfaces, Nanosheets, Cancer, Signal attenuation, Scanning electron microscopy
We report a graphene oxide integrated optical biosensor for the detection of breast cancer cell media. The graphene oxide nanosheets-coated long period grating (GO-LPG) serves as an optical transducer where the GO acts as a bridging interface between optical sensor and external medium. The principle of the optical biosensor is based on alerting the optical signal as a change of local refractive index caused by different analyte concentrations. The proposed biosensor has been implemented to detect the breast cancer cell media with ultrahigh sensitivity, opening the path as a bio-nano-photonic platform for biosensing and early diagnosis.
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