Ms. Huifang Liu Profile

Huifang Liu

at Xi'an Jiaotong Univ

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 9 October 2021 Poster + Paper

Sequentially responsive peptide assembling liposomes integrating photosensitizer and immune drug for enhanced photodynamic/immunotherapy in skin melanoma

Huifang Liu, Sijia Wang, Jing Wang, Cuiping Yao, Zhenxi Zhang

Proceedings Volume 11900, 119002G (2021) https://doi.org/10.1117/12.2601449

KEYWORDS: Photodynamic therapy, Tumors, Melanoma, Nanoparticles, In vivo imaging, In vitro testing

Read Abstract +

Combining photodynamic therapy (PDT) and immunotherapy modalities has shown encouraging therapeutic efficacy against various metastasis cancers. Developing a functional nanoparticle for tumor-targeting and on-demand release of drug is still a major focus for advancing therapeutic approach. Herein, we assembled a β-cyclodextrin (β-CD) modified MMP-2 responsive peptide with a photosensitizer-loaded liposome to construct a tumor immune microenvironment and laser dual-triggered nano system (matrix metalloproteinase 2 (MMP-2) responsive peptide liposome, MR@Lip) for melanoma therapy. The β-CDs encapsulating SB-3CT were released due to the cleavage of the peptide substrate by MMP-2 which is highly expressed in tumor stroma. The localized released SB-3CT was kept in the stroma and inhibited the expression of MMP, down-regulating the soluble NKG2D ligands. The liposome loading photosensitizer Ce6 targeted and killed melanoma cells under laser irradiation, while induced the expression of NKG2D ligands and finally leading to an increase in sensitivity of A375 cells to NK cells. This study might provide novel insight into the development of a new nanomedicine to achieve programmed release of antitumor drugs and better integration of PDT and immune therapy for melanoma.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years