Ms. Jessica D. Flores Profile

Jessica D. Flores

at Johns Hopkins Univ

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Author

Publications (2)

SPIE Journal Paper | 9 April 2021

Direct reconstruction of anatomical change in low-dose lung nodule surveillance

Jessica Flores, Grace Gang, Hao Zhang, Chen Ting Lin, Shui K. Fung, J. Webster Stayman

JMI, Vol. 8, Issue 02, 023503, (April 2021) https://doi.org/10.1117/12.10.1117/1.JMI.8.2.023503

KEYWORDS: Image registration, Lung, Surveillance, Image analysis, X-ray computed tomography, Tissues, Rigid registration, Data acquisition, Visualization, Reconstruction algorithms

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Proceedings Article | 15 February 2021 Presentation + Paper

Generative adversarial networks and radiomics supervision for lung lesion synthesis

Shaoyan Pan, Jessica Flores, Chen Ting Lin, J. Webster Stayman, Grace Gang

Proceedings Volume 11595, 115950O (2021) https://doi.org/10.1117/12.2582151

KEYWORDS: Lung, Solids, Databases, Optical inspection

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Realistic lesion generation is a useful tool for system evaluation and optimization. Generated lesions can serve as realistic imaging tasks for task-base image quality assessment, as well as targets in virtual clinical trials. In this work, we investigate a data-driven approach for categorical lung lesion synthesis using public lung CT databases. We propose a generative adversarial network with a Wasserstein discriminator and gradient penalty to stabilize training. We further included conditional inputs such that the network can generate user-specified lesion categories. Novel to our network, we directly incorporated radiomic features in an intermediate supervision step to encourage similar textures between generated and real lesions. We calculated the network using lung lesions from the Lung Image Database Consortium (LIDC) database. Lesions are divided into two categories: solid vs. non-solid. We performed quantitative evaluation of network performance based on four criteria: 1) overfitting, in terms of structural and morphological similarity to the training data, 2) diversity of generated lesions, in terms of similarity to other generated data, 3) similarity to real lesions, in terms of distribution of example radiomics features, and 4) conditional consistency, in terms of classification accuracy using a classifier trained on the training lesions. We imposed a quantitative threshold for similarity based on visual inspection. The percentage of non-solid and solid lesions that satisfy low overfitting and high diversity is 87.1% and 70.2% of non-solid and solid lesions respectively. The distribution of example radiomics features are similar in the generated and real lesions indicated by low Kullback–Leibler divergence scores: 1.62 for non-solid lesions and 1.13 for solid lesions. Classification accuracy for the generated lesions are comparable with that for the real lesions. The proposed network presents a promising approach for generating realistic lesions with clinically relevant features crucial for the comprehensive assessment of novel medical imaging systems.

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