Dr. Jinjun Xia Profile

Dr. Jinjun Xia

Postdoctoral Fellow at Univ of Washington

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Author

Publications (11)

Proceedings Article | 11 March 2015 Paper

Real-time interleaved photoacoustic/ultrasound (PAUS) imaging for interventional procedure guidance

Chen-wei Wei, Thu-Mai Nguyen, Jinjun Xia, Bastien Arnal, Ivan Pelivanov, Matthew O’Donnell

Proceedings Volume 9323, 93233J (2015) https://doi.org/10.1117/12.2084704

KEYWORDS: Tissues, Imaging systems, Mirrors, Ultrasonography, Laser scanners, Signal to noise ratio, Image fusion, Pulsed laser operation, 3D scanning, Visualization

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Proceedings Article | 3 March 2014 Paper

Clinically translatable integrated ultrasound and photoacoustic imaging system

Jinjun Xia, Chen-wei Wei, Thu-Mai Nguyen, Bastien Arnal, Ivan Pelivanov, Matthew O'Donnell

Proceedings Volume 8943, 894310 (2014) https://doi.org/10.1117/12.2038025

KEYWORDS: Imaging systems, Ultrasonography, Pulsed laser operation, Mirrors, Laser scattering, System integration, Signal to noise ratio, Field programmable gate arrays, Image fusion, Photoacoustic imaging

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Proceedings Article | 3 March 2014 Paper

Inertial cavitation in theranostic nanoemulsions with simultaneous pulsed laser and low frequency ultrasound excitation

Bastien Arnal, Chen-Wei Wei, Jinjun Xia, Ivan Pelivanov, Michael Lombardo, Camilo Perez, Thomas Matula, Danilo Pozzo, Matthew O'Donnell

Proceedings Volume 8943, 89433E (2014) https://doi.org/10.1117/12.2042348

KEYWORDS: Cavitation, Pulsed laser operation, Acoustics, Absorption, Ultrasonography, Therapeutics, Gold, Transducers, Laser damage threshold, Signal detection

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Proceedings Article | 3 March 2014 Paper

Nonlinear acoustic enhancement in photoacoustic imaging with wideband absorptive nanoemulsion beads

Chen-wei Wei, Michael Lombardo, Jinjun Xia, Ivan Pelivanov, Camilo Perez, Kjersta Larson-Smith, Thomas Matula, Danilo Pozzo, Matthew O’Donnell

Proceedings Volume 8943, 894325 (2014) https://doi.org/10.1117/12.2042312

KEYWORDS: Nonlinear optics, Absorption, Satellite navigation systems, Ultrasonography, Molecular imaging, Imaging systems, Signal processing, Gold, Pulsed laser operation, Acoustics

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Proceedings Article | 4 March 2013 Paper

Magnetic trapping with simultaneous photoacoustic detection of molecularly targeted rare circulating tumor cells

Chen-Wei Wei, Jinjun Xia, Ivan Pelivanov, Xiaoge Hu, Xiaohu Gao, Matthew O’Donnell

Proceedings Volume 8581, 85814W (2013) https://doi.org/10.1117/12.2008969

KEYWORDS: Magnetism, Target detection, Composites, Tumors, Signal detection, Imaging systems, Photoacoustic spectroscopy, Particles, Blood, Photoacoustic imaging

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Proceedings Article | 4 March 2013 Paper

Contrast enhancement by simultaneous ultrasound/laser pulse probing of gold nanosphere encapsulated emulsion beads

Chen-wei Wei, Kjersta Larson-Smith, Ivan Pelivanov, Camilo Perez, Jinjun Xia, Danilo Pozzo, Thomas Matula, Matthew O’Donnell

Proceedings Volume 8581, 858112 (2013) https://doi.org/10.1117/12.2009077

KEYWORDS: Pulsed laser operation, Satellite navigation systems, Nonlinear optics, Gold, Laser scattering, Absorption, Composites, Signal detection, Optical filters, Electronic filtering

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SPIE Journal Paper | 14 August 2012 Open Access

Trapping and dynamic manipulation of polystyrene beads mimicking circulating tumor cells using targeted magnetic/photoacoustic contrast agents

Chen-Wei Wei, Jinjun Xia, Ivan Pelivanov, Xiaoge Hu, Xiaohu Gao, Matthew O'Donnell

JBO, Vol. 17, Issue 10, 101517, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.101517

KEYWORDS: Magnetism, Blood, Absorption, Tumors, Image fusion, Target detection, Signal detection, Composites, Biomedical optics, Photoacoustic imaging

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SPIE Journal Paper | 14 May 2012 Open Access

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

Jinjun Xia, Ivan Pelivanov, Chenwei Wei, Xiaoge Hu, Xiaohu Gao, Matthew O’Donnell

JBO, Vol. 17, Issue 06, 061224, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061224

KEYWORDS: Particles, Magnetism, Signal detection, Photoacoustic imaging, Blood, Absorption, Transducers, Target detection, Nanoparticles, Imaging systems

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Proceedings Article | 23 February 2012 Paper

Trapping and dynamic manipulation with magnetomotive photoacoustic imaging of targeted microspheres mimicking metastatic cancer cells trafficking in the vasculature

Chenwei Wei, Jinjun Xia, Ivan Pelivanov, Xiaoge Hu, Xiaohu Gao, Matthew O'Donnell

Proceedings Volume 8223, 82231R (2012) https://doi.org/10.1117/12.909053

KEYWORDS: Magnetism, Photoacoustic imaging, Cancer, Absorption, Imaging systems, Blood, Nanoprobes, Photoacoustic spectroscopy, Gold, Nanorods

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Proceedings Article | 18 February 2011 Paper

Dynamic manipulation of magnetic contrast agents in photoacoustic imaging

Congxian Jia, Jinjun Xia, Ivan Pelivanov, Chi Hyung Seo, Xiaoge Hu, Yongdong Jin, Xiaohu Gao, Matthew O'Donnell

Proceedings Volume 7899, 78991R (2011) https://doi.org/10.1117/12.876057

KEYWORDS: Magnetism, Particles, Nanoparticles, Photoacoustic imaging, Tumors, Imaging systems, Blood, Absorption, Gold, In vivo imaging

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Proceedings Article | 18 February 2011 Paper

Comparison of PA imaging by narrow beam scanning and one-shot broad beam excitation

Jinjun Xia, Chen-Wei Wei, Lingyun Huang, I. Pelivanov, Matthew O'Donnell

Proceedings Volume 7899, 78991L (2011) https://doi.org/10.1117/12.875879

KEYWORDS: Imaging systems, Spatial resolution, Acoustics, Transducers, Laser tissue interaction, Fiber lasers, Tissue optics, Signal to noise ratio, Tissues, Pulsed laser operation

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Current systems designed for deep photoacoustic (PA) imaging typically use a low repetition rate, high power pulsed laser to provide a ns-scale pulse illuminating a large tissue volume. Acoustic signals recorded on each laser firing can be used to reconstruct a complete 2-D (3-D) image of sources of heat release within that region. Using broad-beam excitation, the maximum frame rate of the imaging system is restricted by the pulse repetition rate of the laser. An alternate illumination approach is proposed based on fast scanning by a low energy (~ 1 mJ) high repetition rate (up to a few kHz) narrow laser beam (~1 mm) along the tissue surface over a region of interest. A final PA image is produced from the summation of individual PA images reconstructed at each laser beam position. This concept can take advantage of high repetition rate fiber lasers to create PA images with much higher frame rates than current systems, enabling true real-time integration of photoacoustics with ultrasound imaging. As an initial proof of concept, we compare conventional broad beam illumination to a scanned beam approach in a simple model system. Two transparent teflon tubes with diameters of 1.6 mm and 0.8 mm were filled with ink having an absorption coefficient of 5 cm^-1. These tubes were buried inside chicken breast tissue acting as an optical scattering medium. They were separated by 3 mm or 10 mm to test spatial and contrast resolution for the two scan formats. The excitation wavelength was 700 nm. The excitation source is a traditional OPO pumped by a Q-switched Nd:YAG laser with doubler. Photoacoustic images were reconstructed using signals from a small, scanned PVDF transducer acting as an acoustic array. Two different illumination schemes were compared: one was 15 mm x 10 mm in cross section and acted as the broad beam; the other was 5 mm x 2 mm in cross section (15 times smaller than the broad beam case) and was scanned over an area equivalent to broad beam illumination. Multiple images obtained during narrow beam scanning were added together to form one PA image equivalent to the single-shot broad beam one. Results of the phantom study indicate that PA images formed by narrow beam scanning excitation can be equivalent to one shot broad beam illumination in signal to noise ratio and spatial resolution. Future studies will focus on high repetition-rate laser sources and scan formats appropriate for real-time, integrated deep photoacoustic/ultrasonic imaging.

Showing 5 of 11 publications

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