Dr. Joseph D. Malone Profile

Dr. Joseph D. Malone

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Author

Publications (17)

Proceedings Article | 9 March 2023 Presentation

DiffuserSpec: a simple computational spectrometer using off-the-shelf diffusers

Neerja Aggarwal, Joseph Malone, Laura Waller, Audrey Bowden

Proceedings Volume PC12428, PC1242804 (2023) https://doi.org/10.1117/12.2649300

KEYWORDS: Spectroscopy, Diffusers, Sensors, Multiplexing, Spectroscopes, Speckle pattern, Speckle, Signal to noise ratio, Reflectivity, Prisms

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Proceedings Article | 7 March 2022 Presentation

Smartphone-based multichannel spectroscopic system for optical biosensing

Iftak Hussain, Emily Kight, Joseph Malone, Frederick Haselton, Audrey Bowden

Proceedings Volume PC11950, PC119500A (2022) https://doi.org/10.1117/12.2610447

KEYWORDS: Optical spectroscopy, Biosensing, Point-of-care devices, Medicine, Multiplexing, Interfaces, Cameras, Absorption, Spectroscopy

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Proceedings Article | 7 March 2022 Presentation

SmartOCT: Design and characterization of a smartphone-integrated line-field optical coherence tomography system

Joseph Malone, Iftak Hussain, Audrey Bowden

Proceedings Volume PC11948, PC119480Y (2022) https://doi.org/10.1117/12.2613219

KEYWORDS: Optical coherence tomography, Imaging systems, Data storage, Data acquisition, Visualization, Spectrometer engineering, Simulink, Sensing systems, Near infrared, MATLAB

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Proceedings Article | 7 March 2022 Presentation

Real-time display and data processing in a smartphone integrated line-field optical coherence tomography system

Iftak Hussain, Joseph Malone, Audrey Bowden

Proceedings Volume PC11950, PC119500N (2022) https://doi.org/10.1117/12.2612402

KEYWORDS: Optical coherence tomography, Data processing, Visualization, Visible radiation, Telemedicine, System integration, Simulink, Optical tracking, MATLAB, Imaging systems

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Proceedings Article | 10 March 2020 Presentation + Paper

Self-fusion for OCT noise reduction

Ipek Oguz, Joseph Malone, Yigit Atay, Yuankai Tao

Proceedings Volume 11313, 113130C (2020) https://doi.org/10.1117/12.2549472

KEYWORDS: Optical coherence tomography, Image fusion, Speckle, Signal to noise ratio, Denoising, Image segmentation, Image registration, Visualization, Retina, Optic nerve

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Proceedings Article | 9 March 2020 Presentation

Handheld spectrally encoded coherence tomography and reflectometry for point-of-care ophthalmic OCT and OCTA (Conference Presentation)

Eric Tang, Joseph Malone, Josh Albert Miller, Ipek Oguz, Yuankai Tao

Proceedings Volume 11228, 112280I (2020) https://doi.org/10.1117/12.2549057

KEYWORDS: Tomography, Reflectometry, Optical coherence tomography, Point-of-care devices, Imaging systems, Coherence (optics), Imaging devices, Angiography, Prototyping, Image resolution

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Proceedings Article | 9 March 2020 Presentation

OCT and fluorescence SLO for guided laser delivery and longitudinal imaging in a murine model of targeted retinal laser injury (Conference Presentation)

Joseph Malone, Edward Levine, Yuankai Tao

Proceedings Volume 11218, 112181E (2020) https://doi.org/10.1117/12.2550167

KEYWORDS: Optical coherence tomography, Injuries, Scanning laser ophthalmoscopy, Imaging systems, Luminescence, Target designation, Eye models, Systems modeling, Control systems, Visualization

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SPIE Journal Paper | 3 July 2019 Open Access

Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography

Joseph Malone, Mohamed El-Haddad, Suhaas Yerramreddy, Ipek Oguz, Yuankai K. Tao

NPh, Vol. 6, Issue 04, 041102, (July 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.4.041102

KEYWORDS: Optical coherence tomography, Coherence (optics), Tomography, Reflectometry, Imaging systems, Angiography, Optical fibers, Mirrors, Retinal scanning, In vivo imaging

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Proceedings Article | 13 March 2019 Presentation

Handheld OCT-A using spectrally encoded coherence tomography and reflectometry (Conference Presentation)

Joseph Malone, Mohamed El-Haddad, Yuankai Tao

Proceedings Volume 10858, 108580Z (2019) https://doi.org/10.1117/12.2510340

KEYWORDS: Reflectometry, Tomography, Optical coherence tomography, Imaging systems, Retinal scanning, Ophthalmic imaging, Lens design, Coherence (optics), Visualization, Fiber couplers

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Proceedings Article | 22 February 2019 Presentation + Paper

Deep-learning based automated instrument tracking and adaptive-sampling of intraoperative OCT for video-rate volumetric imaging of ophthalmic surgical maneuvers

Mohamed El-Haddad, Joseph Malone, Nancy Hoang, Yuankai Tao

Proceedings Volume 10867, 108671M (2019) https://doi.org/10.1117/12.2511827

KEYWORDS: Optical coherence tomography, Neural networks, Microcontrollers, Surgery, Optical tracking, Image segmentation, Data acquisition, Coherence (optics), Tomography, Reflectometry, Ophthalmology, Ophthalmic imaging, Scanning laser ophthalmoscopy

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Proceedings Article | 14 February 2018 Paper

Resolution and throughput optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) for multimodal imaging during ophthalmic microsurgery

Joseph Malone, Mohamed El-Haddad, Kelsey Leeburg, Benjamin Terrones, Yuankai Tao

Proceedings Volume 10483, 1048316 (2018) https://doi.org/10.1117/12.2292138

KEYWORDS: Optical coherence tomography, Microscopes, Objectives, In vivo imaging, Reflectometry, Visualization, Retinal scanning, Relays, Image resolution, Tomography

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Proceedings Article | 14 February 2018 Paper

Multimodal ophthalmic imaging using handheld spectrally encoded coherence tomography and reflectometry (SECTR)

Kelsey Leeburg, Mohamed El-Haddad, Joseph Malone, Benjamin Terrones, Yuankai Tao

Proceedings Volume 10483, 1048306 (2018) https://doi.org/10.1117/12.2292132

KEYWORDS: Optical coherence tomography, Ophthalmic imaging, Reflectometry, Retinal scanning, Relays, Coherence (optics), Tomography, Scanning laser ophthalmoscopy, Diagnostics, Mirrors

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Proceedings Article | 29 August 2017 Presentation + Paper

Multimodal ophthalmic imaging using spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Mohamed El-Haddad, Joseph Malone, Jianwei Li, Ivan Bozic, Amber Arquitola, Karen Joos, Shriji Patel, Yuankai Tao

Proceedings Volume 10352, 1035209 (2017) https://doi.org/10.1117/12.2275552

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Ophthalmic imaging, In vivo imaging, Signal detection, Multimodal imaging, Scanners, Imaging systems, Optical scanning systems, Optical tracking

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Ophthalmic surgery involves manipulation of delicate, layered tissue structures on milli- to micrometer scales. Traditional surgical microscopes provide an inherently two-dimensional view of the surgical field with limited depth perception which precludes accurate depth-resolved visualization of these tissue layers, and limits the development of novel surgical techniques. We demonstrate multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (SS-SESLO-OCT) to address current limitations of image-guided ophthalmic microsurgery. SS-SESLO-OCT provides inherently co-registered en face and cross-sectional field-of-views (FOVs) at a line rate of 400 kHz and >2 GPix/s throughput. We show in vivo imaging of the anterior segment and retinal fundus of a healthy volunteer, and preliminary results of multi-volumetric mosaicking for ultrawide-field retinal imaging with 90° FOV. Additionally, a scan-head was rapid-prototyped with a modular architecture which enabled integration of SS-SESLO-OCT with traditional surgical microscope and slit-lamp imaging optics. Ex vivo surgical maneuvers were simulated in cadaveric porcine eyes. The system throughput enabled volumetric acquisition at 10 volumes-per-second (vps) and allowed visualization of surgical dynamics in corneal sweeps, compressions, and dissections, and retinal sweeps, compressions, and elevations. SESLO en face images enabled simple real-time co-registration with the surgical microscope FOV, and OCT cross-sections provided depth-resolved visualization of instrument-tissue interactions. Finally, we demonstrate novel augmented-reality integration with the surgical view using segmentation overlays to aid surgical guidance. SS-SESLO-OCT may benefit clinical diagnostics by enabling aiming, registration, and mosaicking; and intraoperative imaging by allowing for real-time surgical feedback, instrument tracking, and overlays of computationally extracted biomarkers of disease.

Proceedings Article | 17 February 2017 Presentation + Paper

Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Ivan Bozic, Mohamed El-Haddad, Joseph Malone, Karen Joos, Shriji Patel, Yuankai Tao

Proceedings Volume 10053, 1005326 (2017) https://doi.org/10.1117/12.2254859

KEYWORDS: Optical coherence tomography, Image registration, Scanning laser ophthalmoscopy, Diagnostics, Coherence imaging, Multimodal imaging, Ophthalmic imaging, Optical imaging, Eye, In vivo imaging, Data acquisition, Retinal scanning, Scanners

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Proceedings Article | 17 February 2017 Presentation + Paper

Image-guided feedback for ophthalmic microsurgery using multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Jianwei Li, Joseph Malone, Mohamed El-Haddad, Amber Arquitola, Karen Joos, Shriji Patel, Yuankai Tao

Proceedings Volume 10053, 100530I (2017) https://doi.org/10.1117/12.2254847

KEYWORDS: Optical coherence tomography, Visualization, Scanning laser ophthalmoscopy, Tissues, In vivo imaging, Microsurgery, Ophthalmic imaging, Microscopes, Multimodal imaging, Eye, Image segmentation, Surgery

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Surgical interventions for ocular diseases involve manipulations of semi-transparent structures in the eye, but limited visualization of these tissue layers remains a critical barrier to developing novel surgical techniques and improving clinical outcomes. We addressed limitations in image-guided ophthalmic microsurgery by using microscope-integrated multimodal intraoperative swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (iSS-SESLO-OCT). We previously demonstrated in vivo human ophthalmic imaging using SS-SESLO-OCT, which enabled simultaneous acquisition of en face SESLO images with every OCT cross-section. Here, we integrated our new 400 kHz iSS-SESLO-OCT, which used a buffered Axsun 1060 nm swept-source, with a surgical microscope and TrueVision stereoscopic viewing system to provide image-based feedback. In vivo human imaging performance was demonstrated on a healthy volunteer, and simulated surgical maneuvers were performed in ex vivo porcine eyes. Denselysampled static volumes and volumes subsampled at 10 volumes-per-second were used to visualize tissue deformations and surgical dynamics during corneal sweeps, compressions, and dissections, and retinal sweeps, compressions, and elevations. En face SESLO images enabled orientation and co-registration with the widefield surgical microscope view while OCT imaging enabled depth-resolved visualization of surgical instrument positions relative to anatomic structures-of-interest. TrueVision heads-up display allowed for side-by-side viewing of the surgical field with SESLO and OCT previews for real-time feedback, and we demonstrated novel integrated segmentation overlays for augmented-reality surgical guidance. Integration of these complementary imaging modalities may benefit surgical outcomes by enabling real-time intraoperative visualization of surgical plans, instrument positions, tissue deformations, and image-based surrogate biomarkers correlated with completion of surgical goals.

Proceedings Article | 8 February 2017 Presentation + Paper

Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging

Joseph Malone, Jianwei Li, Mohamed El-Haddad, Karen Joos, Shriji Patel, Yuankai Tao

Proceedings Volume 10045, 100451D (2017) https://doi.org/10.1117/12.2252315

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Ophthalmic imaging, Multimodal imaging, In vivo imaging, Imaging systems, Relays, Non-invasive medical diagnostics, Visualization, Fiber couplers, Microscopes, Mirrors, Computer aided design

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Proceedings Article | 4 March 2016 Presentation + Paper

Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Joseph Malone, Mohamed El-Haddad, Logan Tye, Lucas Majeau, Nicolas Godbout, Andrew Rollins, Caroline Boudoux, Yuankai Tao

Proceedings Volume 9693, 96930Q (2016) https://doi.org/10.1117/12.2212859

KEYWORDS: Optical coherence tomography, Imaging systems, Scanning laser ophthalmoscopy, Ophthalmic imaging, In vivo imaging, Confocal microscopy, Image registration, Speckle, Multimodal imaging, Diagnostics, Mirrors, Scanners

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Showing 5 of 17 publications

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