Dr. Lee-Way Jin Profile

Dr. Lee-Way Jin

at Univ of California Davis

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Author

Publications (6)

Proceedings Article | 13 March 2024 Presentation

Optical biopsy of brain tumors using fluorescence lifetime imaging (FLIm)

Silvia Noble Anbunesan, Alba Alfonso Garcia, Julien Bec, Mohamed Hassan, Lisanne Kraft, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC12831, PC1283101 (2024) https://doi.org/10.1117/12.3001898

KEYWORDS: Biopsy, Brain, Tumors, Neuroimaging, Fluorescence lifetime imaging, Tissues, Magnetic resonance imaging, Brain tissue, Windows, Tissue optics

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Proceedings Article | 13 March 2024 Presentation

Detecting infiltrative edges of brain tumors using label-free intraoperative FLIm

Mohamed Hassan, Silvia Noble Anbunesan, Alba Alfonso García, Matthew Bobinski, Han Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC12831, PC1283102 (2024) https://doi.org/10.1117/12.3003609

KEYWORDS: Tumors, Cancer detection, Brain, Edge detection, Tissues, Surgery, Resection, Receivers, Performance modeling, Neuroimaging

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Proceedings Article | 6 March 2023 Presentation + Paper

Intraoperative detection of IDH-mutant glioma subtype using fluorescence lifetime imaging

Silvia Noble Anbunesan, Alba Alfonso-Garcia, Xiangnan Zhou, Julien Bec, Matthew Bobinski, Han Sung Lee, Lee-way Jin, Orin Bloch, Laura Marcu

Proceedings Volume 12368, 1236803 (2023) https://doi.org/10.1117/12.2650379

KEYWORDS: Tumors, Tissues, Resection, White matter, Fluorescence, Fluorescence lifetime imaging, Surgery, Medicine, Brain tissue, Brain

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Proceedings Article | 9 March 2022 Presentation

Real-time interrogation of brain tumors using intraoperative FLIm

Silvia Noble Anbunesan, Alba Alfonso García, Xiangnan Zhou, Julien Bec, Roberto Frusciante, Lisanne Kraft, Brent Weyers, Matthew Bobinski, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu

Proceedings Volume PC11949, PC1194904 (2022) https://doi.org/10.1117/12.2610424

KEYWORDS: Tumors, Brain, Tissues, Neuroimaging, Luminescence, Surgery, Statistical analysis, Pulsed laser operation, Proteins, Laser tissue interaction

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SPIE Journal Paper | 2 February 2022 Open Access

First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence

Alba Alfonso García, Xiangnan Zhou, Julien Bec, Silvia Anbunesan, Farzad Fereidouni, Lee-Way Jin, Han Sung Lee, Orin Bloch, Laura Marcu

JBO, Vol. 27, Issue 02, 020501, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.020501

KEYWORDS: Luminescence, Tumors, Tissues, Brain, Microscopes, In vivo imaging, Surgery, Video, Data acquisition, Visualization

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Significance: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is currently used for image-guided glioma resection. Typically, this widefield imaging method highlights the bulk of high-grade gliomas, but it underperforms at the infiltrating edge where PpIX fluorescence is not visible to the eyes. Fluorescence lifetime imaging (FLIm) has the potential to detect PpIX fluorescence below the visible detection threshold. Moreover, simultaneous acquisition of time-resolved nicotinamide adenine (phosphate) dinucleotide [NAD(P)H] fluorescence may provide metabolic information from the tumor environment to further improve overall tumor detection. Aim: We investigate the ability of pulse sampling, fiber-based FLIm to simultaneously image PpIX and NAD(P)H fluorescence of glioma infiltrative margins in patients. Approach: A mesoscopic fiber-based point-scanning FLIm device (355 nm pulses) was used to simultaneously resolve the fluorescence decay of PpIX (629/53 nm) and NAD(P)H (470/28 nm). The FLIm device enabled data acquisition at room light and rapid (<33 ms) augmentation of FLIm parameters on the surgical field-of-view. FLIm measurements from superficial tumors and tissue areas around the resection margins were performed on three glioblastoma patients in vivo following inspection of PpIX visible fluorescence with a conventional neurosurgical microscope. Microbiopsies were collected from FLIm imaged areas for histopathological evaluation. Results: The average lifetime from PpIX and NAD(P)H fluorescence distinguished between tumor and surrounding tissue. FLIm measurements of resection margins presented a range of PpIX and NAD(P)H lifetime values (τPpIX   ∼ 3 to 14 ns, τNAD(P)H = 3 to 6 ns) associated with unaffected tissue and areas of low-density tumor infiltration. Conclusions: Intraoperative FLIm could simultaneously detect the emission of PpIX and NAD(P)H from patients in vivo during craniotomy procedures. This approach doubles as a clinical tool to identify tumor areas while performing tissue resection and as a research tool to study tumor microenvironmental changes in vivo. Intraoperative FLIm of 5-ALA-induced PpIX and tissue autofluorescence makes a promising surgical adjunct to guide tumor resection surgery.

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Proceedings Article | 5 March 2021 Presentation

1700 nm optical coherence microscopy enables minimally invasive, volumetric, deep tissue optical biopsy of the mouse brain in vivo

Jun Zhu, Hercules Freitas, Izumi Maezawa, Lee-Way Jin, Vivek Srinivasan

Proceedings Volume 11629, 1162910 (2021) https://doi.org/10.1117/12.2577001

KEYWORDS: Tissue optics, Brain, In vivo imaging, Optical coherence microscopy, Biopsy, Signal attenuation, Neuroimaging, Coherence (optics), Tissues, Statistical analysis

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