Dr. Mohammad Ardavan Eghtedari Profile

Dr. Mohammad Ardavan Eghtedari

Resident at University of California San Diego

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Publications (7)

Proceedings Article | 1 May 2017 Presentation

Fiber sensor assisted in-vivo needle guidance for minimally invasive procedures (Conference Presentation)

Saharnaz Baghdadchi, Cherng Chao, Sadik Esener, Robert Mattrey, Mohammad Eghtedari

Proceedings Volume 10060, 100600X (2017) https://doi.org/10.1117/12.2253016

KEYWORDS: Liver, Biopsy, Fluoroscopy, X-rays, Fiber optics sensors, In vivo imaging, Skin, Blood vessels, Modulation, Tissue optics

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SPIE Journal Paper | 1 June 2011 Open Access

Characterization of individual ultrasound microbubble dynamics with a light-scattering system

Mark Hsu, Sadik Esener, Mohammad Eghtedari, David Hall, Robert Mattrey, Andrew Goodwin

JBO, Vol. 16, Issue 06, 067002, (June 2011) https://doi.org/10.1117/12.10.1117/1.3583575

KEYWORDS: Ultrasonography, Acoustics, Light scattering, Cavitation, Signal to noise ratio, Silica, Fourier transforms, Lanthanum, Diagnostics, Mie scattering

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Proceedings Article | 28 February 2008 Paper

Optoacoustic system for 3D functional and molecular imaging in nude mice

Matthew Fronheiser, Alan Stein, Don Herzog, Scott Thompson, Anton Liopo, Mohammad Eghtedari, Massoud Motamedi, Sergey Ermilov, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Ketan Mehta, Alexander Oraevsky

Proceedings Volume 6856, 68560R (2008) https://doi.org/10.1117/12.770461

KEYWORDS: Imaging systems, Tissues, Tumors, Sensors, Gold, Molecular imaging, Image resolution, 3D image processing, Tissue optics, Nanorods

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A three-dimensional laser optoacoustic imaging system was developed, which combines the advantages of optical spectroscopy and high resolution ultrasonic detection, to produce high contrast maps of optical absorbance in tissues. This system was tested in a nude mouse model of breast cancer and produced tissue images of tumors and vasculature. The imaging can utilize either optical properties of hemoglobin and oxyhemoglobin, which are the main endogenous tissue chromophores in the red and near-infrared spectral ranges, or exogenous contrast agent based on gold nanorods. Visualization of tissue molecules targeted by the contrast agent provides molecular information. Visulization of blood at multiple colors of light provides functional information on blood concentration and oxygen saturation. Optoacoustic imaging, using two or more laser illumination wavelengths, permits an assessment of the angiogenesis-related microvasculature, and thereby, an evaluation of the tumor stage and its metastatic potential. The optoacoustic imaging system was also used to generate molecular images of the malignancy-related receptors induced by the xenografts of BT474 mammary adenocarcinoma cells in nude mice. The development of the latter images was facilitated by the use of an optoacoustic contrast agent that utilizes gold nanorods conjugated to monoclonal antibody raised against HER2/neu antigens. These nanorods possess a very strong optical absorption peak that can be tuned in the near-infrared by changing their aspect ratio. The effective conversion of the optical energy into heat by the gold nanorods, followed by the thermal expansion of the surrounding water, makes these nanoparticles an effective optoacoustic contrast agent. Optical scattering methods and x-ray tomography may also benefit from the application of this contrast agent. Administration of the gold nanorod bioconjugates to mice resulted in an enhanced contrast of breast tumors relative the background of normal tissues in the nude mouse model. The combination of this novel contrast agent and optoacoustic imaging has the potential to become a useful imaging modality, for preclinical research in murine models of cancer and other human diseases.

Proceedings Article | 19 February 2007 Paper

Functionalized gold nanorod particles for molecular optoacoustic imaging

Mohammad Eghtedari, Alexander Oraevsky, Andre Conjusteau, John Copland, Nicholas Kotov, Massoud Motamedi

Proceedings Volume 6437, 64370G (2007) https://doi.org/10.1117/12.716380

KEYWORDS: Gold, Nanoparticles, Signal detection, Laser irradiation, Transducers, In vivo imaging, Absorption, Skin, Cancer, Nanorods

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Proceedings Article | 6 March 2006 Paper

Metallic nanoparticles as optoacoustic contrast agents for medical imaging

Andre Conjusteau, Sergey Ermilov, Dmitri Lapotko, Hongwei Liao, Jason Hafner, Mohammad Eghtedari, Massoud Motamedi, Nicholas Kotov, Alexander Oraevsky

Proceedings Volume 6086, 60860K (2006) https://doi.org/10.1117/12.658065

KEYWORDS: Nanoparticles, Gold, Tumors, Particles, Absorption, Plasmons, Laser damage threshold, Water, Cancer, Nanorods

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Proceedings Article | 12 July 2004 Paper

Optoacoustic imaging of gold nanoparticles targeted to breast cancer cells

Mohammad Eghtedari, Massoud Motamedi, Vsevolod Popov, Nicholas Kotov, Alexander Oraevsky

Proceedings Volume 5320, (2004) https://doi.org/10.1117/12.534464

KEYWORDS: Nanoparticles, Gold, Tumors, Cancer, Tissues, Breast cancer, Absorption, Signal detection, Neptunium, Breast

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Proceedings Article | 1 July 2003 Paper

Bioconjugated gold nanoparticles as a contrast agent for optoacoustic detection of small tumors

Mohammad Eghtedari, John Copland, Vsevolod Popov, Nicholas Kotov, Massoud Motamedi, Alexander Oraevsky

Proceedings Volume 4960, (2003) https://doi.org/10.1117/12.503617

KEYWORDS: Gold, Nanoparticles, Tumors, Cancer, Absorption, Tissue optics, Neptunium, Signal detection, Acoustics, Tissues

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