Surface-enhanced Raman spectroscopy (SERS) has made significant progress in recent decades, primarily driven by the principles of plasmon on metal surfaces. In contrast, SERS on non-metal substrates is based on the chemical mechanism involving charge transfer (CT) processes within irradiated molecules and the resonance Raman effect. This plasmon-free SERS mechanism proves highly suitable for detecting biomedical samples, as it suppresses the photo-thermal conversion associated with plasmon. In this study, we developed non-metal SERS substrates using conducting polymer nanofibers through electropolymerization. We evaluated the CT process and performance of the conducting polymer SERS substrates.
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy, but is compromised by its low reproducibility, uniformity, biocompatibility, and durability. This is because it depends on “hot spots” for high signal enhancement. Here we report our experimental demonstration of a plasmon-free nanostructure composed of a two-dimensional array of porous carbon nanowires as a SERS substrate for highly sensitive, biocompatible, and reproducible SERS. Specifically, the substrate provides not only high signal enhancement, but also high reproducibility and fluorescence quenching capability. We experimentally demonstrated these excellent properties with various molecules such as rhodamine 6G (R6G), β-lactoglobulin, and glucose.
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