Prof. Nick Stone Profile

Prof. Nick Stone

at Univ of Exeter

SPIE Involvement:

Conference Program Committee | Author

Publications (57)

Proceedings Article | 18 June 2024 Paper

Entropy-based spatial heterogeneity analysis in pathological images for diagnostic applications

Rahul Suresh, Thi Nguyet Que Nguyen, Pascaline Bouzy, Nicholas Stone, Karin Jirstrom, Arman Rahman, William Gallagher, Aidan Meade

Proceedings Volume 13011, 130110E (2024) https://doi.org/10.1117/12.3022363

KEYWORDS: Tissues, FT-IR spectroscopy, Image information entropy, Diseases and disorders, Diagnostics, Cancer, Breast cancer, Imaging spectroscopy, Image analysis, Statistical analysis

Read Abstract +

Proceedings Article | 11 January 2023 Presentation

Variations in hippocampal lipid studied by coherent Raman and Infrared micro-spectroscopy in a mouse model of Alzheimer's-related tau pathology.

Hao Meng, Alicia Elliott, Jessica Mansfield, Nick Stone, Francesco Tamagnini, Francesca Palombo

Proceedings Volume 12333, 123330D (2023) https://doi.org/10.1117/12.2643538

KEYWORDS: Raman spectroscopy, Infrared radiation, Mouse models, Alzheimer's disease, Pathology, Mode conditioning cables, Pathogens, Microscopy, Spatial resolution, Optical microscopy

Read Abstract +

Proceedings Article | 2 March 2022 Presentation

Correlative Brillouin–Raman microscopy in biomedical sciences

Francesca Palombo, Michelle Bailey, Martina Alunni Cardinali, Noemi Correa, Nick Stone, Daniele Fioretto

Proceedings Volume PC11962, PC1196201 (2022) https://doi.org/10.1117/12.2609767

KEYWORDS: Microscopy, Biomedical optics, Tissues, Proteins, Physiology, Mechanics, Biopsy, Anisotropy, Acoustics

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Review of life science applications using submicron O-PTIR and simultaneous Raman microscopy: a new paradigm in vibrational spectroscopy

Mustafa Kansiz, Alice Spadea, Jayakrupakar Nallala, Cassio Lima, Howbeer Muhamadali, Joanna Denbigh, Jayne Lawrence, Gorkem Bakir, Peter Gardner, Nick Stone, Roy Goodacre, Kathleen Gough, Oxana Klementieva

Proceedings Volume 11656, 1165617 (2021) https://doi.org/10.1117/12.2578662

KEYWORDS: Raman spectroscopy, Microscopy, Spectroscopy, Life sciences, Infrared microscopy, Photoacoustic spectroscopy, Laser optics, Infrared spectroscopy, Infrared imaging

Read Abstract +

Proceedings Article | 19 February 2018 Paper

Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber

Christian Rosenberg Petersen, Nikola Prtljaga, Mark Farries, Jon Ward, Bruce Napier, Gavin Rhys Lloyd, Jayakrupakar Nallala, Nick Stone, Ole Bang

Proceedings Volume 10489, 1048905 (2018) https://doi.org/10.1117/12.2288541

KEYWORDS: Supercontinuum generation, Supercontinuum sources, Spectroscopy, Mid-IR, Imaging spectroscopy, Imaging systems, Tissues, Absorption, FT-IR spectroscopy, Chalcogenides, Photonic crystal fibers, Tissue optics

Read Abstract +

Proceedings Article | 13 February 2018 Paper

Characterisation of a novel transmission Raman spectroscopy platform for non-invasive detection of breast micro-calcifications

Adrian Ghita, Pavel Matousek, Nick Stone

Proceedings Volume 10490, 104900G (2018) https://doi.org/10.1117/12.2297632

KEYWORDS: Tissues, Raman spectroscopy, Breast, Spectroscopy, Breast cancer, In vivo imaging, Diagnostics

Read Abstract +

Proceedings Article | 13 February 2018 Paper

Long wavelength identification of microcalcifications in breast cancer tissue using a quantum cascade laser and upconversion detection

Y. P. Tseng, P. Bouzy, N. Stone, C. Pedersen, P. Tidemand-Lichtenberg

Proceedings Volume 10490, 104900F (2018) https://doi.org/10.1117/12.2290928

KEYWORDS: Upconversion, Breast cancer, Long wavelength infrared, Carbonates, Tissues, Quantum cascade lasers, Sensors, Infrared radiation, Absorption

Read Abstract +

Proceedings Article | 28 July 2017 Paper

Mid-infrared spectroscopy in skin cancer cell type identification

Lena Kastl, Björn Kemper, Gavin Lloyd, Jayakrupakar Nallala, Nick Stone, Valery Naranjo, Francisco Penaranda, Jürgen Schnekenburger

Proceedings Volume 10413, 104130S (2017) https://doi.org/10.1117/12.2287263

Read Abstract +

Proceedings Article | 17 February 2017 Presentation + Paper

Performance of mid infrared spectroscopy in skin cancer cell type identification

Lena Kastl, Björn Kemper, Gavin Lloyd, Jayakrupakar Nallala, Nick Stone, Valery Naranjo, Francisco Penaranda, Jürgen Schnekenburger

Proceedings Volume 10060, 1006006 (2017) https://doi.org/10.1117/12.2253314

KEYWORDS: Skin, Spectroscopy, Skin cancer, Mid-IR, Biopsy, Melanoma, Imaging spectroscopy, Optical spectroscopy, Tissue optics, In vivo imaging, Tumors, Luminescence, 3D modeling, Standards development, 3D image processing

Read Abstract +

Proceedings Article | 7 March 2016 Presentation + Paper

Potential of mid IR spectroscopy in the rapid label free identification of skin malignancies

Lena Kastl, Björn Kemper, Gavin Lloyd, Jayakrupakar Nallala, Nick Stone, Valery Naranjo, Francisco Penaranda, Jürgen Schnekenburger

Proceedings Volume 9703, 970307 (2016) https://doi.org/10.1117/12.2208897

KEYWORDS: Skin, Mid-IR, Tumors, Luminescence, Tissues, 3D modeling, Melanoma, Infrared spectroscopy, Chemical analysis, Diagnostics, Spectroscopy, Standards development, Biopsy, Tissue optics

Read Abstract +

Proceedings Article | 7 March 2016 Presentation + Paper

The road map towards providing a robust Raman spectroscopy-based cancer diagnostic platform and integration into clinic

Katherine Lau, Martin Isabelle, Gavin Lloyd, Oliver Old, Neil Shepherd, Ian Bell, Jennifer Dorney, Aaran Lewis, Riana Gaifulina, Manuel Rodriguez-Justo, Catherine Kendall, Nicolas Stone, Geraint Thomas, David Reece

Proceedings Volume 9704, 97040B (2016) https://doi.org/10.1117/12.2230007

KEYWORDS: Raman spectroscopy, Cancer, Data modeling, Diagnostics, Tissues, Pathology, Tissue optics, Statistical modeling, Remote sensing, Tumor growth modeling

Read Abstract +

Proceedings Article | 7 March 2016 Paper

Investigating the effect of pixel size of high spatial resolution FTIR imaging for detection of colorectal cancer

G. Lloyd, J. Nallala, N. Stone

Proceedings Volume 9703, 970306 (2016) https://doi.org/10.1117/12.2210844

KEYWORDS: FT-IR spectroscopy, Colorectal cancer, Diagnostics, Spatial resolution, Fourier spectroscopy, Biomedical optics, Imaging spectroscopy, Spectroscopy, Medical diagnostics, Tissues, Pathology, Statistical analysis, Tissue optics, Microscopes, Tumors

Read Abstract +

Proceedings Article | 7 March 2016 Presentation + Paper

A two-step framework for the registration of HE stained and FTIR images

Francisco Peñaranda, Valery Naranjo, Rafaél Verdú, Gavin Lloyd, Jayakrupakar Nallala, Nick Stone

Proceedings Volume 9703, 970305 (2016) https://doi.org/10.1117/12.2208869

KEYWORDS: Multimodal imaging, Imaging spectroscopy, Absorbance, Image processing, Chromium, Image segmentation, Hyperspectral imaging, Physical phenomena, Cancer, New and emerging technologies, Colorectal cancer, Tissues, Feature extraction, Spectroscopy, FT-IR spectroscopy, Image registration

Read Abstract +

Proceedings Article | 7 March 2016 Presentation + Paper

Identification of GI cancers utilising rapid mid-infrared spectral imaging

Jayakrupakar Nallala, Gavin Lloyd, Catherine Kendall, Hugh Barr, Neil Shepherd, Nick Stone

Proceedings Volume 9703, 970303 (2016) https://doi.org/10.1117/12.2209363

KEYWORDS: Cancer, Mid-IR, Imaging spectroscopy, Tissues, Tumors, Infrared imaging, Pathology, FT-IR spectroscopy, Statistical modeling, Statistical analysis

Read Abstract +

Proceedings Article | 7 March 2016 Presentation + Paper

Towards supercontinuum-driven hyperspectral microscopy in the mid-infrared

I. Lindsay, S. Valle, J. Ward, G. Stevens, M. Farries, L. Huot, C. Brooks, P. Moselund, R. Vinella, M. Abdalla, D. de Gaspari, R. M. von Wurtemberg, S. Smuk, H. Martijn, J. Nallala, N. Stone, C. Barta, R. Hasal, U. Moller, O. Bang, S. Sujecki, A. Seddon

Proceedings Volume 9703, 970304 (2016) https://doi.org/10.1117/12.2210836

KEYWORDS: Imaging spectroscopy, Tunable lasers, FT-IR spectroscopy, Microscopes, Spectroscopy, Synchrotrons, Chalcogenides, Optical fibers, Supercontinuum sources, Imaging systems, Sensors, Microscopy, Mid-IR

Read Abstract +

Proceedings Article | 7 March 2016 Paper

Towards the mid-infrared optical biopsy

Angela Seddon, Trevor Benson, Slawomir Sujecki, Nabil Abdel-Moneim, Zhuoqi Tang, David Furniss, Lukasz Sojka, Nick Stone, Nallala Jayakrupakar, Gavin Lloyd, Ian Lindsay, Jon Ward, Mark Farries, Peter Moselund, Bruce Napier, Samir Lamrini, Uffe Møller, Irnis Kubat, Christian Petersen, Ole Bang

Proceedings Volume 9703, 970302 (2016) https://doi.org/10.1117/12.2211584

KEYWORDS: Mid-IR, Optical fibers, Surgery, Biopsy, Medical diagnostics, Cancer, Biomedical optics, Photonics, Fiber optics, Chalcogenide glass, Tissue optics, Tissues, Spectroscopy, In vivo imaging, Fiber lasers

Read Abstract +

Proceedings Article | 7 March 2016 Paper

Evaluation of a multi-fibre needle Raman probe for tissue analysis

Leanne Fullwood, Ingeborg Iping Petterson, Alexander Dudgeon, Gavin Lloyd, Catherine Kendall, Charlie Hall, John C. Day, Nick Stone

Proceedings Volume 9704, 97040G (2016) https://doi.org/10.1117/12.2230005

KEYWORDS: Raman spectroscopy, Tissues, Lymphatic system, Cancer, Spectroscopy, Fiber optics, Tissue optics, Optical fibers, Light scattering, Surgery, Diagnostics, In vivo imaging, Biopsy, Visualization, Bone

Read Abstract +

SPIE Journal Paper | 3 September 2012 Open Access

Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia

L. Max Almond, Joanne Hutchings, Catherine Kendall, Gavin Lloyd, John Day, Oliver Stevens, Neil Shepherd, Hugh Barr, Nicholas Stone

JBO, Vol. 17, Issue 8, 081421, (September 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.081421

KEYWORDS: Raman spectroscopy, Endoscopy, Tissues, Biopsy, Diagnostics, Spectroscopy, Tissue optics, Remote sensing, In vivo imaging, Cancer

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 1 February 2012 Paper

Assessing the performance of spectroscopic models for cancer diagnostics using cross-validation and permutation testing

G. Lloyd, J. Hutchings, L. Almond, H. Barr, C. Kendall, N. Stone

Proceedings Volume 8219, 82190C (2012) https://doi.org/10.1117/12.919864

KEYWORDS: Computer simulations, Raman spectroscopy, Spectroscopy, Cancer, Tumor growth modeling, Diagnostics, Surface plasmons, Statistical modeling, Performance modeling, Spectroscopes

Read Abstract +

Proceedings Article | 1 February 2012 Paper

Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies

L. M. Almond, J. Hutchings, G. Lloyd, J. Francis-Jones, N. Stone, H. Barr, C. Kendall

Proceedings Volume 8219, 82190L (2012) https://doi.org/10.1117/12.919876

KEYWORDS: Prototyping, Cancer, Tissues, Imaging systems, Pathology, Remote sensing, Spectroscopy, Tissue optics, Endoscopy, Raman spectroscopy

Read Abstract +

Proceedings Article | 9 June 2011 Paper

Infrared spectroscopy to estimate the gross biochemistry associated with different colorectal pathologies

J. Wood, C. Kendall, G. LLoyd, N. Shepherd, T. Cook, N. Stone

Proceedings Volume 8087, 80870P (2011) https://doi.org/10.1117/12.889605

KEYWORDS: Tissues, FT-IR spectroscopy, Cancer, Infrared spectroscopy, Pathology, Biological research, Colorectal cancer, Biopsy, Colon, Tissue optics

Read Abstract +

Proceedings Article | 1 June 2011 Paper

Screening cervical and oesophageal tissues using optical coherence tomography

Gavin R. Erry, Florian Bazant-Hegemark, Mike Read, Nicholas Stone

Proceedings Volume 8091, 809122 (2011) https://doi.org/10.1117/12.889678

KEYWORDS: Tissues, Optical coherence tomography, Scattering, Principal component analysis, Cancer, Light sources, Mirrors, Biopsy, Cervical cancer, Roads

Read Abstract +

SPIE Journal Paper | 1 November 2010 Open Access

Evaluation of linear discriminant analysis for automated Raman histological mapping of esophageal high-grade dysplasia

Joanne Hutchings, Catherine Kendall, Neil Shepherd, Hugh Barr, Nicholas Stone

JBO, Vol. 15, Issue 06, 066015, (November 2010) https://doi.org/10.1117/12.10.1117/1.3512244

KEYWORDS: Raman spectroscopy, Tissues, Pathology, Data modeling, Associative arrays, Spatial resolution, Statistical modeling, Biological research, Tissue optics, Performance modeling

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 3 March 2010 Paper

Raman spectroscopy as a tool for the identification and differentiation of neoplasias contained within lymph nodes of the head and neck

Linda Orr, Jonathan Christie-Brown, Joanne Hutchings, Keith McCarthy, Simon Rose, Michael Thomas, Nicholas Stone

Proceedings Volume 7548, 75481W (2010) https://doi.org/10.1117/12.848784

KEYWORDS: Diagnostics, Pathology, Tumor growth modeling, Head, Tissues, Cancer, Neck, Raman spectroscopy, Lymphoma, Lymphatic system

Read Abstract +

SPIE Journal Paper | 1 March 2010 Open Access

Correlation mapping: rapid method for identification of histological features and pathological classification in mid infrared spectroscopic images of lymph nodes

Martin Isabelle, Keith Rogers, Nicholas Stone

JBO, Vol. 15, Issue 02, 026030, (March 2010) https://doi.org/10.1117/12.10.1117/1.3386061

KEYWORDS: Lymphatic system, Tissues, Tissue optics, FT-IR spectroscopy, Spectroscopy, Pathology, Tumors, Imaging spectroscopy, Mid-IR, Cancer

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 12 February 2010 Paper

Ultra-low spatial resolution Raman mapping using a novel fibre optic probe

J. Hutchings, C. Kendall, N. Shepherd, H. Barr, J. Day, N. Stone

Proceedings Volume 7560, 75600N (2010) https://doi.org/10.1117/12.858803

KEYWORDS: Raman spectroscopy, Tissues, Pathology, Biopsy, In vivo imaging, Cancer, Luminescence, Fiber optics, Principal component analysis, Spatial resolution

Read Abstract +

Proceedings Article | 23 February 2009 Paper

Bladder cancer diagnosis during cystoscopy using Raman spectroscopy

M. C. M. Grimbergen, C. F. P. van Swol, R. O. P. Draga, P. van Diest, R. M. Verdaasdonk, N. Stone, J. H. L. R. Bosch

Proceedings Volume 7161, 716114 (2009) https://doi.org/10.1117/12.807811

KEYWORDS: Raman spectroscopy, Tissues, Pathology, Bladder, Bladder cancer, Biopsy, Signal to noise ratio, Endoscopy, Tumors, Statistical analysis

Read Abstract +

SPIE Journal Paper | 1 May 2008 Open Access

Near real-time classification of optical coherence tomography data using principal components fed linear discriminant analysis

Florian Bazant-Hegemark, Nicholas Stone

JBO, Vol. 13, Issue 03, 034002, (May 2008) https://doi.org/10.1117/12.10.1117/1.2931079

KEYWORDS: Optical coherence tomography, Fourier transforms, Principal component analysis, Tissues, Image classification, Binary data, Biomedical optics, Data modeling, Coherence (optics), Detection and tracking algorithms

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 3 March 2008 Paper

Novel Raman signal recovery from deeply buried tissue components

Nicholas Stone, Rebecca Baker, Consuelo Hart Prieto, Pavel Matousek

Proceedings Volume 6853, 68530N (2008) https://doi.org/10.1117/12.786442

KEYWORDS: Liver, Calcium, Light scattering, Natural surfaces, Tissue optics, Picosecond phenomena, Luminescence, Breast, Tissues, Raman spectroscopy

Read Abstract +

Proceedings Article | 28 February 2008 Paper

Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications

Jon Holmes, Simon Hattersley, Nick Stone, Florian Bazant-Hegemark, Hugh Barr

Proceedings Volume 6847, 68470O (2008) https://doi.org/10.1117/12.761655

KEYWORDS: Optical coherence tomography, Tissues, Imaging systems, Channel projecting optics, Image resolution, Biomedical optics, Bessel beams, Cancer, Tissue optics, In vivo imaging

Read Abstract +

Proceedings Article | 8 February 2008 Paper

Raman point mapping of tear ferning patterns

Jacob Filik, Nicholas Stone

Proceedings Volume 6853, 685309 (2008) https://doi.org/10.1117/12.786441

KEYWORDS: Proteins, Raman spectroscopy, Image processing, Urea, Coating, Principal component analysis, Eye, Analytical research, Biological research, Biomedical optics

Read Abstract +

Proceedings Article | 8 February 2008 Paper

Rapid Raman microscopic imaging for potential histological screening

Joanne Hutchings, Catherine Kendall, Neil Shepherd, Hugh Barr, Brian Smith, Nicholas Stone

Proceedings Volume 6853, 685305 (2008) https://doi.org/10.1117/12.786440

KEYWORDS: Raman spectroscopy, Signal to noise ratio, Associative arrays, Tissues, Biopsy, Charge-coupled devices, Connective tissue, Brain mapping, Pathology, Cancer

Read Abstract +

Proceedings Article | 19 July 2007 Paper

FT-infrared spectroscopic studies of lymphoma, lymphoid, and myeloid leukemia cell lines

Jaspreet Babrah, Keith McCarthy, Richard Lush, Adam Rye, Conrad Bessant, Nicholas Stone

Proceedings Volume 6628, 66280R (2007) https://doi.org/10.1117/12.728220

KEYWORDS: FT-IR spectroscopy, Lymphoma, Leukemia, Lymphatic system, Statistical analysis, Principal component analysis, Spectroscopy, Proteins, Absorption, Visualization

Read Abstract +

Proceedings Article | 11 July 2007 Paper

Improvements in Alzheimer's disease diagnosis using principle components analysis (PCA) in combination with Raman spectroscopy

John Archer, Caroline Sudworth, Rachel Williams, Thien How, Nicholas Stone, David Mann, Richard Black

Proceedings Volume 6628, 662810 (2007) https://doi.org/10.1117/12.728464

KEYWORDS: Tissues, Raman spectroscopy, Alzheimer's disease, Principal component analysis, Tissue optics, Data modeling, Dementia, Brain, Brain mapping, Proteins

Read Abstract +

Proceedings Article | 11 July 2007 Paper

FTIR biochemical imaging of the prostate: an in vitro proof of concept study

J. Aning, M. Isabelle, J. Uff, A. Ritchie, H. Gilbert, N. Stone

Proceedings Volume 6628, 66280F (2007) https://doi.org/10.1117/12.727855

KEYWORDS: Pathology, Prostate, FT-IR spectroscopy, Prostate cancer, Tissues, Collagen, Cancer, Glucose, Gold, In vitro testing

Read Abstract +

Proceedings Article | 11 July 2007 Paper

Optical coherence tomography (OCT) imaging and computer aided diagnosis of human cervical tissue specimens

F. Bazant-Hegemark, N. Stone, M. Read, K. McCarthy, R. Wang

Proceedings Volume 6627, 66270F (2007) https://doi.org/10.1117/12.728366

KEYWORDS: Optical coherence tomography, Biopsy, Cervical cancer, Cancer, Tissues, Diagnostics, Coherence imaging, Tissue optics, Image classification, Computer aided diagnosis and therapy

Read Abstract +

Proceedings Article | 11 July 2007 Paper

Analysis of breast tissue calcifications using FTIR spectroscopy

Rebecca Baker, Keith Rogers, Neil Shepherd, Nicholas Stone

Proceedings Volume 6628, 66280I (2007) https://doi.org/10.1117/12.728240

KEYWORDS: Tissues, Carbonates, Breast, FT-IR spectroscopy, Spectroscopy, Pathology, Calcium, Tissue optics, Mammography, Tumor growth modeling

Read Abstract +

SPIE Journal Paper | 1 March 2007 Open Access

Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy

Pavel Matousek, Nicholas Stone

JBO, Vol. 12, Issue 02, 024008, (March 2007) https://doi.org/10.1117/12.10.1117/1.2718934

KEYWORDS: Raman spectroscopy, Tissues, Breast, Tissue optics, Photons, Breast cancer, Mammography, Calcium, In vivo imaging, Raman scattering

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 27 February 2006 Paper

Vibrational spectroscopic analysis of breast calcifications and surrounding tissue

Rebecca Baker, Jennifer Smith, Keith Rogers, Nicholas Stone

Proceedings Volume 6093, 60930X (2006) https://doi.org/10.1117/12.644497

KEYWORDS: FT-IR spectroscopy, Raman spectroscopy, Tissues, Breast, Spectroscopy, Carbonates, Tissue optics, Calcium, Synchrotrons, Absorbance

Read Abstract +

Proceedings Article | 27 February 2006 Paper

Infrared spectroscopy: a novel tool to aid classification of DCIS

K. Subramanian, N. Stone, C. Kendall, J. C. Brown, K. McCarthy, J. Bristol, Y. H. Chan

Proceedings Volume 6093, 60930J (2006) https://doi.org/10.1117/12.644512

KEYWORDS: Statistical analysis, Proteins, Pathology, Breast, Tissue optics, Tumor growth modeling, Infrared radiation, Absorption, Tissues, Infrared spectroscopy

Read Abstract +

Proceedings Article | 27 February 2006 Paper

Raman spectroscopic biochemical mapping of tissues

Nicholas Stone, Maria Hart Prieto, Catherine Kendall, Geeta Shetty, Hugh Barr

Proceedings Volume 6093, 60930U (2006) https://doi.org/10.1117/12.644178

KEYWORDS: Tissues, Raman spectroscopy, Pathology, Spectroscopy, Collagen, Cancer, Biological research, Imaging spectroscopy, Visualization, Bladder

Read Abstract +

Proceedings Article | 22 February 2006 Paper

Feasibility of Raman spectroscopy in vitro after 5-ALA-based fluorescence diagnosis in the bladder

M. Grimbergen, C. van Swol, R. van Moorselaar, A, Mahadevan-Jansen, N. Stone

Proceedings Volume 6078, 60781D (2006) https://doi.org/10.1117/12.655616

KEYWORDS: Raman spectroscopy, Biopsy, Luminescence, Bladder, Tissues, Tumors, In vitro testing, Algorithm development, Bladder cancer, Pathology

Read Abstract +

Proceedings Article | 21 February 2006 Paper

Raman spectroscopic analysis of atypical proliferative lesions of the breast

K. Subramanian, C. Kendall, N. Stone, J. Brown, K. McCarthy, J. Bristol, Y. Chan

Proceedings Volume 6088, 60880B (2006) https://doi.org/10.1117/12.644553

KEYWORDS: Breast, Raman spectroscopy, Pathology, Breast cancer, Tissues, Chemical analysis, Cancer, Principal component analysis, Tumor growth modeling, Spectroscopy

Read Abstract +

Atypical lesions of the breast have potential to turn malignant. The diagnosis of these lesions has increased considerably with screening mammography. A good understanding of their progression to invasive cancer is yet to be proved. Using Raman spectroscopy to study their chemical finger printing at different stages of proliferation a clear picture of whether a progression exists between lesions could be made. At present there is no clear recognition of the biochemical changes that distinguish between the different proliferative lesions of the breast. Our aim is to understand these changes through Raman mapping studies. Raman spectroscopy is a highly sensitive and specific technique for demonstration of biochemical changes in different atypical proliferative lesions of the breast. The technique could be used to classify the different grades and analyse progression of pathology in the proliferative lesions of the breast. Breast pathologists carefully marked 50 ducts and classified the different pathology on H and E sections from biopsy samples. Raman spectra were measured, using a Renishaw Raman Spectrometer, on a 20-micron thick consecutive frozen section. Principal component analysis was undertaken using Matlab. Pseudocolor maps of the principal components scores have been generated. The peaks of the corresponding loads were identified enabling visualisation of the biochemical changes associated with proliferative lesions. Proliferative lesions of the duct were grouped according to the existing standard pathological classification and formed four major groups-HUT, ADH, DCIS and IDC. Spectra of biochemical constituents were fitted to mean spectra from selected regions, taken from maps of each pathology, to identify the relative concentration of the constituents. The study gave an insight into chemical make up of the ducts in each pathology group and showed similar results to earlier studies in progression but no clear-cut demarcation or continuum of the proliferative disease.

Proceedings Article | 8 October 2005 Paper

Raman spectroscopy is sensitive and specific in the detection of lymph node metastases in breast cancer

Jenny Smith, Catherine Kendall, Alastair Sammon, Jonathan Christie-Brown, Trupti Mandalia, Nicholas Stone

Proceedings Volume 5862, 586202 (2005) https://doi.org/10.1117/12.633004

KEYWORDS: Lymphatic system, Raman spectroscopy, Breast cancer, Tumor growth modeling, Tissues, Collagen, Biochemistry, Imaging spectroscopy, Spectroscopy, Tissue optics

Read Abstract +

SPIE Journal Paper | 1 July 2005 Open Access

Use of picosecond Kerr-gated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue

Maria Consuelo Hart Prieto, Pavel Matousek, Michael Towrie, Anthony Parker, Mark Wright, Alastair Ritchie, Nicholas Stone

JBO, Vol. 10, Issue 04, 044006, (July 2005) https://doi.org/10.1117/12.10.1117/1.1991848

KEYWORDS: Raman spectroscopy, Prostate, Bladder, Tissue optics, Tissues, Picosecond phenomena, Biopsy, Urea, Tumors, Natural surfaces

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 1 July 2004 Paper

Urological applications of Raman spectroscopy for improved malignant diagnostics

M. Consuelo Hart Prieto, Paul Crow, Catherine Kendall, Jeremy Uff, Mark Wright, Alistair Ritchie, Nicholas Stone

Proceedings Volume 5321, (2004) https://doi.org/10.1117/12.528907

KEYWORDS: Tumor growth modeling, Raman spectroscopy, Prostate, Bladder, Biopsy, Cancer, Data modeling, Bladder cancer, Pathology, Diagnostics

Read Abstract +

Proceedings Article | 1 July 2004 Paper

Axillary lymph node analysis using Raman spectroscopy

Jenny Smith, Jonathan Christie-Brown, Alastair Sammon, Nicholas Stone

Proceedings Volume 5321, (2004) https://doi.org/10.1117/12.528916

KEYWORDS: Raman spectroscopy, Lymphatic system, Breast cancer, Tissues, Diagnostics, Tissue optics, Breast, Spectroscopy, Tumor growth modeling, Cancer

Read Abstract +

Proceedings Article | 9 October 2003 Paper

Multiphoton imaging in the detection of malignancy in the oesophagus

Catherine Kendall, Karen McCloskey, Nicholas Stone, Hugh Barr, Douglas Greenhalgh

Proceedings Volume 5139, (2003) https://doi.org/10.1117/12.500486

KEYWORDS: Collagen, Tissues, Tissue optics, Luminescence, Biomedical optics, Visualization, Cancer, Biopsy, Microscopes, Imaging systems

Read Abstract +

Proceedings Article | 8 October 2003 Paper

Raman spectral mapping for the illumination of biochemical changes associated with malignancy in the oesophagus

Catherine Kendall, Nicholas Stone, Neil Shepherd, Hugh Barr

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.500438

KEYWORDS: Proteins, Raman spectroscopy, Tissue optics, Tissues, Spectroscopy, Biological research, Pathology, Optical spectroscopy, Statistical analysis, Surgery

Read Abstract +

Proceedings Article | 8 October 2003 Paper

Surface-enhanced Raman scattering of the tear film

Janelle Reyes-Goddard, Anthony Woodman, Nicholas Stone, Hugh Barr, John Creighton, Yuika Saito, David Batchelder

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.500643

KEYWORDS: Glucose, Raman spectroscopy, Raman scattering, Glasses, Surface enhanced Raman spectroscopy, Mirrors, Electrodes, Thin films, Gold, Silver

Read Abstract +

Proceedings Article | 8 October 2003 Paper

Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastases

Jenny Smith, Catherine Kendall, Jay Christie-Brown, Alastair Sammon, Nicholas Stone

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.500472

KEYWORDS: Raman spectroscopy, Lymphatic system, Breast, Tissues, Breast cancer, Diagnostics, Tumor growth modeling, Tissue optics, Pathology, Principal component analysis

Read Abstract +

Proceedings Article | 27 March 2002 Paper

Near-infrared Raman spectroscopy for detection and classification of gastrointestinal disease

Nicholas Stone, Catherine Kendall, Nitya Chandratreya, Neil Shepherd, Hugh Barr

Proceedings Volume 4614, (2002) https://doi.org/10.1117/12.460788

KEYWORDS: Statistical modeling, Data modeling, Cancer, Statistical analysis, Spectroscopy, Colon, Biopsy, Tissues, Pathology, Raman spectroscopy

Read Abstract +

Proceedings Article | 27 March 2002 Paper

Optimum procedure for construction of spectral classification algorithms for medical diagnosis

Catherine Kendall, Hugh Barr, Neil Shepherd, Nicholas Stone

Proceedings Volume 4614, (2002) https://doi.org/10.1117/12.460791

KEYWORDS: Pathology, Statistical modeling, Gold, Raman spectroscopy, Tumor growth modeling, Spectroscopy, Cancer, Tissues, Biopsy, Diagnostics

Read Abstract +

Proceedings Article | 16 November 2000 Paper

Raman spectroscopy for the diagnosis of dysplasia in columnar and squamous epithelium

Catherine Kendall, Tom Bakker Schut, Nicholas Stone, Pela Stravroulaki, Gerwin Puppels, Hugh Barr

Proceedings Volume 4161, (2000) https://doi.org/10.1117/12.409321

KEYWORDS: In vitro testing, Pathology, Cancer, Tissues, Raman spectroscopy, In vivo imaging, Statistical analysis, Spectroscopy, Tissue optics, Biopsy

Read Abstract +

Proceedings Article | 8 May 2000 Paper

Raman spectroscopy: a diagnostic tool for detection of early malignant changes in the larynx

Nicholas Stone, Pelagia Stavroulaki, Catherine Kendall, Martin Birchall, Hugh Barr

Proceedings Volume 3918, (2000) https://doi.org/10.1117/12.384933

KEYWORDS: Raman spectroscopy, Tissues, Pathology, Diagnostics, Biopsy, Statistical analysis, Cancer, Near infrared, Biological research, Tissue optics

Read Abstract +

Proceedings Article | 8 May 2000 Paper

Progress in the detection of neoplastic progress and cancer by Raman spectroscopy

Tom Bakker Schut, Nicholas Stone, Catherine Kendall, Hugh Barr, Hajo Bruining, Gerwin Puppels

Proceedings Volume 3918, (2000) https://doi.org/10.1117/12.384932

KEYWORDS: Raman spectroscopy, Tissues, Tissue optics, Biopsy, Data modeling, Cancer, Statistical modeling, Tumor growth modeling, Spectroscopy, Pathology

Read Abstract +

Proceedings Article | 11 December 1996 Paper

Optical measurements on human synovial fluid and its relevance to pathology

Nicholas Stone, Hugh Barr, Rafi Ahmad

Proceedings Volume 2927, (1996) https://doi.org/10.1117/12.260655

KEYWORDS: Absorption, Pathology, Scattering, Luminescence, Contamination, Optical testing, Tissues, Diagnostics, Light scattering, Rayleigh scattering

Read Abstract +