The work is devoted to determining the diffusion coefficient of methylene blue in human gum tissue in vitro using spectroscopic methods. The calculations are based on the application of the free diffusion model, the second Fick law, and the modified Bouguer – Lambert – Beer law. For the first time, the diffusion coefficient of methylene blue into the tissue of the human gingival mucosa in vitro was determined, which, by averaging 10 samples is (1.26±0.34)·10–7 cm2/s. It was revealed that after the gum is completely stained with dye, the light does not pass into the biological tissue from 200-699 nm, which includes the areas of dye absorption peaks necessary for photoactivation of the dye during photodynamic therapy. The results obtained are important for the personified choice of this method in vivo in the treatment of superficial pathological localizations.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.