Dr. Paolo Tomassini Profile

Dr. Paolo Tomassini

at Istituto Nazionale di Ottica

SPIE Involvement:

Author

Publications (7)

Proceedings Article | 8 June 2023 Presentation + Paper

Towards high-sensitivity and low-dose medical imaging with laser x-ray sources

D. Stutman, N. Safca, P. Tomassini, E. Anghel, C. Ur

Proceedings Volume 12582, 1258207 (2023) https://doi.org/10.1117/12.2664833

KEYWORDS: X-rays, X-ray sources, Laser interferometry, Refraction, X-ray imaging, Interferometers, Mammography, Phase contrast, Medical imaging, Absorption

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Proceedings Article | 18 April 2021 Presentation

Perspectives for effective applications of laser-driven Very High Energy Electrons in medicine and biology

Luca Labate, Daniele Palla, Daniele Panetta, M. Avella, Federica Baffigi, Fernando Brandi, Fabio Di Martino, Lorenzo Fulgentini, Antonio Giulietti, Petra Koester, Davide Terzani, Paolo Tomassini, Claudio Traino, Leonida Gizzi

Proceedings Volume 11790, 1179009 (2021) https://doi.org/10.1117/12.2596504

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The direct use of so-called Very High Energy Electrons for radiotherapy is currently deserving a renewed and growing attention. This is mostly due to the recent emergence of the so-called FLASH effect in radiobiology [1], consisting in a surprising reduction of adverse effects on healthy tissue by ionizing radiation when dose delivery occurs at very high average dose rates (greater than a few tens of Gy/s). In order for a real clinical translation of this new protocol in the clinical practice, the development of novel kind of ionizing radiation sources featuring such very high dose rates, which are basically hindered by the relatively low Bremsstrahlung conversion efficiency in current machines, is considered as an essential step. With this respect, laser-driven accelerators of Very High Energy Electron (VHEE) beams, with energy in the range 100-250 MeV, are regarded as one of the most promising tool [2]. Furthermore, both early studies, dating back to 1990s, and more recent works suggest that an improved dose deposition pattern can be expected from electron beams, as compared to photon beams, when the very high energy region is reached. In this talk, we report on a recent experiment aimed at assessing dose deposition for deep seated tumors using advanced irradiation schemes, typical of current radiotherapy protocols, with an existing laser-driven VHEE source [3]. In particular, our measurements showed control of localized dose deposition and modulation, suitable to target a volume at depths in the range from 5 to 10 cm with mm resolution. Based on this experimental findings and on further numerical simulations, we also discuss the features and potentialities of laser-driven VHEE sources for radiobiology experiments aimed at deepening the understanding of the mechanisms underpinning the FLASH effect. The main requirements and the perspectives for a longer term translation of an electron-based radiotherapy into the real clinical practice will be also addressed. [1] M.-C. Vozenin et al., Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken, Clin. Oncol. 31 (2019), 407 [2] A. Giulietti (Eds), Laser-Driven Particle Acceleration Towards Radiobiology and Medicine, Springer (2016) [3] L. Labate et al., Toward an effective use of laser‐driven very high energy electrons for radiotherapy: Feasibility assessment of multi‐field and intensity modulation irradiation schemes, Sci. Rep. 10 (2020), 17307

Proceedings Article | 14 May 2019 Presentation

Lossless generation of pulse trains to drive high quality LWFA (Conference Presentation)

Luca Labate, Lorenzo Fulgentini, Guido Toci, Paolo Tomassini, Leonida Gizzi

Proceedings Volume 11037, 110370K (2019) https://doi.org/10.1117/12.2521053

KEYWORDS: Ultrafast phenomena, Plasma, Ionization, Laser energy, Laser development, Pulsed laser operation, Numerical simulations

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Proceedings Article | 7 May 2017 Presentation + Paper

High-quality electron bunch production for high-brilliance Thomson Scattering sources

Paolo Tomassini, Luca Labate, Pasquale Londrillo, Renato Fedele, Davide Terzani, Leonida Gizzi

Proceedings Volume 10240, 102400T (2017) https://doi.org/10.1117/12.2266938

KEYWORDS: Thomson scattering, Photons, Laser systems engineering, Laser scattering, Optical simulations, Argon, Plasma, Pulsed laser operation, Ionization, Electron beams, Free electron lasers, Wave propagation, Particle beams

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Proceedings Article | 23 May 2007 Paper

Production of plasma channels in gas-jets

A. Gamucci, M. Galimberti, D. Giulietti, L. Gizzi, T. Hosokai, L. Labate, C. Petcu, P. Tomassini, A. Giulietti

Proceedings Volume 6634, 66341J (2007) https://doi.org/10.1117/12.742063

KEYWORDS: Plasma, Electrons, Pulsed laser operation, Helium, Interferometry, Wave propagation, Femtosecond phenomena, Prisms, Gases, Fringe analysis

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Proceedings Article | 23 May 2007 Paper

Novel types of ionizing radiation sources at LNF-PLASMONX facility

Danilo Giulietti, Antonio Giulietti, Leonida Gizzi, Paolo Tomassini, Luca Serafini, Vittoria Petrillo, Cristina Vaccarezza, Massimo Ferrario, Piernicola Oliva, Simone Stumbo, Pasquale Delogu, Ubaldo Bottigli, Sergio Bertolucci, Mario Calvetti

Proceedings Volume 6634, 66341F (2007) https://doi.org/10.1117/12.742090

KEYWORDS: Electrons, X-rays, Ionizing radiation, Ion beams, Plasma, Diagnostics, Cancer, Ions, Laser scattering, Tissues

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