Dr. Sudhakar Vadivelu Profile

Dr. Sudhakar Vadivelu

at Cincinnati Childrens Hospital Medical Ctr

SPIE Involvement:

Author

Publications (2)

SPIE Journal Paper | 12 March 2024 Open Access

Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

Olivia Kline, Karthik Vishwanath, Boyd Colbrunn, Andrew Peachman, Jing Zhang, Sudhakar Vadivelu

JBO, Vol. 29, Issue 03, 037002, (March 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.3.037002

KEYWORDS: Tissues, Tissue optics, Statistical analysis, Data modeling, Hemodynamics, Oxygen, Diffuse reflectance spectroscopy, Scattering, Reflectivity, Skin

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SignificanceShuntodynia is patient reported pain at the site of the implanted ventriculoperitoneal (VP) shunt. Pediatric hydrocephalus requiring shunt placement is a chronic and prevalent standard of care treatment and requires lifetime management. Shuntodynia is a subjective measure of shunt dysfunction. Quantitative, white-light tissue spectroscopy could be used to objectively identify this condition in the clinic.AimPediatric subjects were recruited for optical sensing during routine clinical follow-up visits, post-VP shunt implantations. Acquired optical signals were translated into skin-hemodynamic signatures and were compared between subjects that reported shuntodynia versus those that did not.ApproachDiffuse reflectance spectroscopy (DRS) measurements were collected between 450 and 700 nm using a single-channel fiber-optical probe from (N=35) patients. Multiple reflectance spectra were obtained by the attending physician from regions both proximal and distal to the VP shunt sites and from a matched contralateral site for each subject. Acquired reflectance spectra were processed quantitatively into functional tissue optical endpoints. A two-way, repeated measures analysis of variance was used to assess whether and which of the optical variables were statistically separable, across subjects with shuntodynia versus those without.ResultsAnalyses indicated that intrapatient differences in vascular oxygen saturation measured between shunt sites relative to that obtained at the scar or contralateral sites was significantly lower in the pain group. We also find that the total hemoglobin concentrations at the shunt site were lowest relative to the other sites for subjects reporting pain. These findings suggest that shuntodynia pain arises in the scalp tissue around the implanted shunts and may be caused due to hypoxia and inflammation.ConclusionsOptically derived hemodynamic variables were statistically significantly different in subjects presenting with shuntodynia relative to those without. DRS could provide a viable mode in routine bedside monitoring of subjects with VP shunts for clinical management and assessment of shuntodynia.

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Proceedings Article | 3 March 2022 Paper

Investigating the use of diffuse reflectance spectroscopy to identify shuntodynia

Olivia Kline, Boyd Colbrunn, Andrew Peachman, Sudhakar Vadivelu, Karthik Vishwanath

Proceedings Volume 11974, 119740B (2022) https://doi.org/10.1117/12.2610159

KEYWORDS: Scattering, Skin, Absorption, Tissue optics, Diffuse reflectance spectroscopy

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