Prof. Sunju Oh Profile

Prof. Sunju Oh

at Kosin Univ

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Publications (2)

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Proceedings Article | 17 March 2023 Presentation

Translaryngeal photobiomodulation therapy using basket-integrated diffusing applicator for tracheostomy-associated fenestrated wound management

Yeachan Lee, Hyoung shin Lee, Seonghee Lim, Hwarang Shin, Sunju Oh, Hyun Wook Kang

Proceedings Volume PC12362, PC123620D (2023) https://doi.org/10.1117/12.2648146

KEYWORDS: Inflammation, Wound healing, Surgery, Modulation, In vivo imaging, Collagen

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Several therapeutic effects of photobiomodultion (PBM) on variable mucosal lesions of the upper aerodigestive tract has been reported. However, the biomodulatory effect of PBM are rarely reported on tracheostomy and tracheal fenestration, which has been increased with the spread of coronavirus disease (COVID-19). In this study, we developed a translaryngeal PBM therapy by using a basket-integrated diffusing applicator (BIDA) to ameliorate the wound healing of fenestrated tracheostoma after surgery. Tracheostomy was performed by using an electrocautery unit (Bovie) to develop an in vivo porcine model of fenestrated tracheostoma with impaired wounds. A 635 nm laser light (200 mW/cm² for 3 min, 36 J/cm²) was applied to the wounds by using BIDA once daily for five days. BIDA was inserted in tracheostomy tube and emitted homogeneous circumferential light into the fenestrated wound without thermal damage. Control highly induced fibrotic expressions of alpha-smooth muscle actin and type-1 collagen with acute inflammation. In contrast, PBM reduced the expressions up to less than 82% of control. Histological scores presented that PBM significantly decreased acute inflammation and overgranulation to two-thirds of control with a small portion of abscess. In addition, a substantial difference in the lumen area was observed between the control and PBM due to the thickened wall. The current study demonstrated that the proposed PBM therapy could ameliorate the impaired wound healing of fenestrated tracheostoma as a result of modulated inflammation and fibrotic responses. Therefore, the translaryngeal PBM with BIDA can be an effective adjuvant therapy for managing the fenestrated wound after tracheostomy.

Proceedings Article | 7 March 2022 Presentation

Photobiomodulation therapy combined with phlorotannin for prevention of tracheal stenosis and granuloma

Yeachan Lee, Hyoung Shin Lee, Hyeonsoo Kim, Sunju Oh, Hyun Wook Kang

Proceedings Volume PC11958, PC119580C (2022) https://doi.org/10.1117/12.2612142

KEYWORDS: Endoscopy, Modulation, Continuous wave operation, Collagen, Bladder

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Tracheal stenosis or granuloma is one of the most frequent complications after tracheostomy as a result of inflammatory, traumatic and fibrotic responses. Recently, multidisciplinary treatment has been used for tracheal stenosis and granuloma such as bronchoscopy, balloon dilation and tracheal surgeries. However, current treatments have risk of morbidity and may worsen the situation with high recurrence rate. The purpose of this study is to develop a novel combined treatment of photobiomodulation (PBM) and phlorotannin (PT) to prevent stenosis and granuloma formation after tracheal injury. The therapeutic effect of the combined treatment was evaluated on transforming growth factor (TGF)-beta-stimulated human tracheal fibroblasts and the developed tracheostomy rodent models. A 405 nm wavelength light was applied for PBM in a continuous-wave mode after treatment with Ecklonia cava-derived PT. MTT assay and western blot analysis showed that 12 J/cm2 of PBM and 100 µg/ml of PT were hardly cytotoxic (less than 20%). The combined treatment significantly inhibited cell migration and suppressed the expressions of alpha-smooth muscle actin and type-1 collagen via the downregulation of SMAD 2/3 and MAPK signaling pathways. Moreover, the proposed combined treatment showed promoted healing of tracheal fenestration wounds by modulating inflammation and overexpressed fibrotic activities on the developed tracheostomy rodent models. Therefore, the combination of PBM and PT demonstrates therapeutic potential for preventing tracheal stenosis and granuloma after tracheostomy.

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