Prof. Valdas Šablinskas Profile

Prof. Valdas Šablinskas

Professor at Vilnius Univ

SPIE Involvement:

Author

Publications (24)

SPIE Journal Paper | 28 April 2023 Open Access

Open Access

Fast and label-free intraoperative discrimination of malignant pancreatic tissue by attenuated total reflection infrared spectroscopy

Rimante Bandzeviciute, Gerald Steiner, Katja Liedel, Jonas Golde, Edmund Koch, Thilo Welsch, Christoph Kahlert, Daniel E. Stange, Marius Distler, Jürgen Weitz, Justinas Ceponkus, Valdas Sablinskas, Christian Teske

JBO, Vol. 28, Issue 04, 045004, (April 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.4.045004

KEYWORDS: Tissues, Tumors, Biological samples, Infrared spectroscopy, Resection, Spectroscopy, Attenuated total reflectance, Surgery, Crystals, Germanium

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Proceedings Article | 6 March 2023 Poster + Paper

Poster + Paper

Fiber-based ATR-IR spectroscopy for an intraoperative diagnosis of normal pancreatic tissue, pancreatitis, and malignant pancreatic lesions

Rimante Bandzeviciute, Gerald Steiner, Katja Liedel, Jonas Golde, Edmund Koch, Thilo Welsch, Christoph Kahlert, Daniel Stange, Marius Distler, Jürgen Weitz, Justinas Ceponkus, Valdas Sablinskas, Christian Teske

Proceedings Volume 12368, 123680H (2023) https://doi.org/10.1117/12.2647405

KEYWORDS: Tissues, Tumors, Infrared spectroscopy, Resection, Spectroscopy, Biological samples, Surgery, Attenuated total reflectance, Education and training

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Proceedings Article | 7 March 2022 Poster

Poster

Optical fiber based SERS sensor for remote detection of cancerous tissues

Valdas Šablinskas, Sonata Adomaviciute-Grabusove, Marius Balodis

Proceedings Volume PC11957, PC1195711 (2022) https://doi.org/10.1117/12.2608974

KEYWORDS: Tissues, Surface enhanced Raman spectroscopy, Remote sensing, Sensors, Optical fibers, Kidney, Biomedical optics, Tissue optics, Surgery, Spectroscopes

Proceedings Article | 6 August 2021 Poster + Paper

Poster + Paper

Magneto-plasmonic nanoparticles for SERS

Valdas Šablinskas, Agnė Zdaniauskienė, Sonata Adomavičiūtė-Grabusovė, Evaldas Stankevičius, Vita Petrikaitė, Tatjana Charkova, Lina Mikoliūnaite, Romualdas Trusovas, Algirdas Selskis, Gediminas Niaura

Proceedings Volume 11797, 117972B (2021) https://doi.org/10.1117/12.2597199

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Magnetism, Gold, Iron, Laser ablation, Raman spectroscopy, Plasmonics, Molecules, Adsorption

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Proceedings Article | 21 February 2020 Paper

Paper

Fiber based SERS studies of cancerous tissues: toward clinical trials

Sonata Adomaviciute, Martynas Velicka, Valdas Sablinskas

Proceedings Volume 11257, 112570T (2020) https://doi.org/10.1117/12.2543029

KEYWORDS: Nanoparticles, Tissues, Optical fibers, Raman spectroscopy, Surface enhanced Raman spectroscopy, Polymethylmethacrylate, Kidney, Silica, Silver, Molecules

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Proceedings Article | 21 February 2020 Paper

Paper

Application of label-free SERS and EC-SERS for detection of traces of drugs in biological fluids

M. Velicka, S. Adomaviciute, E. Zacharovas, V. Sablinskas

Proceedings Volume 11257, 112570S (2020) https://doi.org/10.1117/12.2542306

KEYWORDS: Nanoparticles, Electrodes, Silver, Blood, Molecules, Gold, Surface enhanced Raman spectroscopy, Spectroscopy, Raman spectroscopy

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Nowadays, with various available choices of non-prescription medication it is quite easy when under illness instead advising with the specialist to self-medicate and try different types of pharmaceuticals at once in order to save time or money. Such unguided or incorrect self-diagnosis of one’s health often results in overdose and other serious health risks. In these cases when such life threatening events occur it is of the most importance to apply early medical treatment. However, specific treatment can be only chosen when the species of pharmaceutical is known. Thus, in order to prevent serious outcomes it is necessary to have a tool which would allow to diagnose the type of drug that was used as soon as possible. The fastest way to gather the required information is to analyze chemically biofluids like blood, saliva or etc. since the pharmaceuticals or their metabolites are contained and transported via biofluids. But the concentration of the molecules to detect is often very low thus the technique not only should be fast but also very sensitive. Of course, there are several clinically available drug screening methods which have already been used for decades and can identify chemical constituents with high sensitivity. Even though such conventional clinically used drug screening methods like liquid chromatography and mass spectroscopy, are sensitive enough, the sample preparation procedure and analysis is not easy and take time. Faster methods would be beneficial and could help avoid serious complications of unguided selfmedication. Vibrational spectroscopy is known to be a reliable tool for chemical composition and structure analysis. Be that as it may, the sensitivity of the conventional vibrational spectroscopy techniques is not sufficient for the detection of trace amounts of molecules. Surface enhanced Raman scattering (SERS) spectroscopy - one of the unconventional methods of vibrational spectroscopy is known to be very sensitive and chemically specific thus suitable for detection of low concentration substances in bodily fluids. This work presents the possible approach of label-free SERS and EC-SERS spectroscopies for application as a faster method for drug screening from biological fluids.

Proceedings Article | 7 March 2019 Presentation + Paper

Presentation + Paper

Screening of usage of OCT drugs by means of SERS spectroscopy

Sonata Adomavičiūtė, Martynas Velička, Valdas Šablinskas

Proceedings Volume 10894, 108940E (2019) https://doi.org/10.1117/12.2508276

KEYWORDS: Blood, Nanoparticles, Surface enhanced Raman spectroscopy, Magnesium, Raman spectroscopy, Silver, Molecules, Metals, Polymers, Optical coherence tomography

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Proceedings Article | 4 March 2019 Presentation

Presentation

Multi-spectral fiber spectroscopy methods as solutions for label-free medical diagnostics (Conference Presentation)

Olga Bibikova, Ervin Nippolainen, Isaac Afara, Julian Haas, Vesa Virtanen, Lasi Rieppo, Sonata Adomaviciute, Harold Brommer, René van Weeren, Anastasia Melenteva, Valeria Belikova, Urszula Zabarylo, Olaf Minet, Juha Töyräs, Valdas Sablinskas, Boris Mizaikoff, Viacheslav Artyushenko

Proceedings Volume 10890, 108901Q (2019) https://doi.org/10.1117/12.2509174

KEYWORDS: Tissues, Medical diagnostics, Spectroscopy, Spectroscopes, Fiber optics, Tissue optics, Kidney, Cartilage, Optical spectroscopy, Molecular spectroscopy

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Proceedings Article | 20 February 2018 Presentation + Paper

Presentation + Paper

In situ detection of cancerous kidney tissue by means of fiber ATR-FTIR spectroscopy

Valdas Sablinskas, Martynas Velicka, Milda Pucetaite, Vidita Urboniene, Justinas Ceponkus, Rimante Bandzeviciute, Feliksas Jankevicius, Tatiana Sakharova, Olga Bibikova, Gerald Steiner

Proceedings Volume 10497, 1049713 (2018) https://doi.org/10.1117/12.2289393

KEYWORDS: Tissues, Spectroscopy, Kidney, Tissue optics, Cancer, Sensors, FT-IR spectroscopy, Infrared spectroscopy, Tumors

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The crucial goal of kidney-sparing surgical resection of a malignant tumor is complete removal of the cancerous tissue. The exact border between the cancerous and normal tissues is not always possible to identify by naked eye, therefore, a supplementary intraoperative diagnosis is needed. Unfortunately, intraoperative pathology methods used nowadays are time consuming and of inadequate quality rendering not definitive diagnosis. It has recently been shown that ATR-FTIR spectroscopy can be used for fast discrimination between cancerous and normal kidney tissues by analyzing the collected spectra of the tissue touch imprint smears. Most prominent differences are obtained in the wavenumber region from 950 cm^-1 to 1250 cm^-1, where the spectral bands due to the molecular vibrations of glycogen arise in the spectra of cancerous tissue smears. Such method of detection of cancerous tissue is limited by requirement to transfer the suspected tissue from the body to the FTIR instrument and stamp it on an ATR crystal of the spectrometer. We propose a spectroscopic tool which exploits the same principle of detection of cancerous cells as mentioned above, but does not require the tissue to be transferred from the body to the spectrometer. The portable spectrometer used in this design is equipped with fiber ATR probe and a sensitive liquid nitrogen cooled MCT detector. The design of the fiber probe allows the ATR tip to be changed easily in order to use only new sterilized tips for each measurement point of the tissue. It also enables sampling multiple areas of the suspected tissue with high lateral resolution which, in turn, increases accuracy with which the marginal regions between normal and cancerous tissues can be identified. Due to the loss of optical signal in the fiber probe the spectra have lower signal-to-noise ratio than in the case of standard ATR sampling setup. However, software for the spectral analysis used with the fiber probe design is still able to distinguish between cancerous and normal tissues with high accuracy.

Proceedings Article | 16 February 2017 Paper

Paper

Assignment of vibrational spectral bands of kidney tissue by means of low temperature SERS spectroscopy

M. Velicka, M. Radzvilaite, J. Ceponkus, V. Urboniene, M. Pucetaite, F. Jankevicius, G. Steiner, V. Sablinskas

Proceedings Volume 10068, 100681W (2017) https://doi.org/10.1117/12.2252907

KEYWORDS: Surface enhanced Raman spectroscopy, Tissues, Kidney, Raman spectroscopy, Cancer, Molecules, Nanoparticles, Silver, Spectroscopy

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Proceedings Article | 7 March 2016 Presentation + Paper

Presentation + Paper

Intra-operative on-line discrimination of kidney cancer from normal tissue by IR ATR spectroscopy of extracellular fluid

V. Urboniene, M. Velicka, J. Ceponkus, M. Pucetaite, F. Jankevicius, V. Sablinskas, G. Steiner

Proceedings Volume 9704, 97040E (2016) https://doi.org/10.1117/12.2213408

KEYWORDS: Tissues, Kidney, Cancer, Absorption, Infrared spectroscopy, Tissue optics, Surgery, Attenuated total reflectance, Principal component analysis, Spectroscopy

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Proceedings Article | 16 September 2015 Paper

Paper

Study of single walled carbon nanotube functionalization by means of surface enhanced Raman spectroscopy

Justinas Ceponkus, Martynas Velicka, Milda Pucetaite, Valdas Sablinskas

Proceedings Volume 9552, 955213 (2015) https://doi.org/10.1117/12.2186223

KEYWORDS: Nanoparticles, Raman spectroscopy, Silver, Surface enhanced Raman spectroscopy, Single walled carbon nanotubes, Chemical species, Carbon nanotubes, Prisms, Particles, Spherical lenses

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Proceedings Article | 21 August 2015 Paper

Paper

Detection of cancerous biological tissue areas by means of infrared absorption and SERS spectroscopy of intercellular fluid

M. Velicka, V. Urboniene, J. Ceponkus, M. Pucetaite, F. Jankevicius, V. Sablinskas

Proceedings Volume 9550, 95500A (2015) https://doi.org/10.1117/12.2186395

KEYWORDS: Tissues, Surface enhanced Raman spectroscopy, Kidney, Absorption, Tissue optics, Infrared spectroscopy, Spectroscopy, Raman spectroscopy, Microfluidics, Surgery

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SPIE Journal Paper | 20 August 2014 Open Access

Open Access

Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix

Vidita Urboniene, Milda Pucetaite, Feliksas Jankevicius, Arunas Zelvys, Valdas Sablinskas, Gerald Steiner

JBO, Vol. 19, Issue 08, 087005, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.087005

KEYWORDS: Tumors, Tissues, FT-IR spectroscopy, Tissue optics, Kidney, Spectroscopy, Absorbance, Infrared spectroscopy, Imaging spectroscopy, Principal component analysis

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Proceedings Article | 4 March 2014 Paper

Paper

Detection of cancerous kidney tissue areas by means of infrared spectroscopy of intercellular fluid

V. Urboniene, F. Jankevicius, A. Zelvys, G. Steiner, V. Sablinskas

Proceedings Volume 8939, 893913 (2014) https://doi.org/10.1117/12.2038539

KEYWORDS: Tumors, Tissues, Kidney, FT-IR spectroscopy, Infrared spectroscopy, Absorption, Tissue optics, Infrared radiation, Proteins, Cancer

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Proceedings Article | 3 March 2014 Paper

Paper

Application of SERS spectroscopy for detection of trace components in urinary deposits

Milda Pucetaite, Martynas Velicka, Sandra Tamosaityte, Valdas Sablinskas

Proceedings Volume 8957, 895708 (2014) https://doi.org/10.1117/12.2040386

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Silver, Calcium, Renal calculi, Urea, Signal detection, Molecules, Statistical analysis, Metals

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Proceedings Article | 18 June 2013 Paper

Paper

Application of infrared reflection microspectroscopy for chemical imaging of cross-sectioned urinary calculi

M. Pucetaite, J. P. Banys, V. Sablinskas

Proceedings Volume 8798, 87980U (2013) https://doi.org/10.1117/12.2032506

KEYWORDS: Imaging spectroscopy, Reflection, Infrared imaging, Infrared radiation, Polishing, Calculi, Calcium, Infrared spectroscopy, Surface roughness, Chemical analysis

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Proceedings Article | 18 June 2013 Paper

Paper

Baseline correction of infrared absorption spectra of urinary sediments by taking mie scattering effects into account

S. Tamosaityte, E. Baltakyte, D. Blazevic, M. Pucetaite, J. Ceponkus, V. Hendrixson, S. Varvuolyte, V. Sablinskas

Proceedings Volume 8798, 87980V (2013) https://doi.org/10.1117/12.2032508

KEYWORDS: Mie scattering, Infrared radiation, Crystals, Absorption, Infrared spectroscopy, Scattering, Calcium, Chemical analysis, Renal calculi, Microscopy

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SPIE Journal Paper | 21 February 2013 Open Access

Open Access

Combined studies of chemical composition of urine sediments and kidney stones by means of infrared microspectroscopy

Sandra Tamosaityte, Vaiva Hendrixson, Arunas Zelvys, Ramunas Tyla, Zita Kucinskiene, Feliksas Jankevicius, Milda Pucetaite, Valerija Jablonskiene, Valdas Sablinskas

JBO, Vol. 18, Issue 02, 027011, (February 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.2.027011

KEYWORDS: Crystals, Renal calculi, Infrared radiation, Spectroscopy, FT-IR spectroscopy, Infrared imaging, Chemical analysis, Calcium, Absorbance, Absorption

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SPIE Journal Paper | 1 September 2011 Open Access

Open Access

Infrared spectroscopic imaging of renal tumor tissue

Valdas Sablinskas, Vidita Urboniene, Justinas Ceponkus, Arvydas Laurinavicius, Darius Dasevicius, Feliksas Jankevicius, Vaiva Hendrixson, Edmund Koch, Gerald Steiner

JBO, Vol. 16, Issue 09, 096006, (September 2011) https://doi.org/10.1117/12.10.1117/1.3622292

KEYWORDS: Tumors, Tissues, Tissue optics, Spectroscopy, Imaging spectroscopy, Infrared spectroscopy, FT-IR spectroscopy, Infrared imaging, Infrared radiation, Absorbance

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Proceedings Article | 23 February 2011 Paper

Paper

Infrared spectroscopic imaging of kidney tumor tissue

V. Sablinskas, G. Steiner, E. Koch, J. Ceponkus, M. Pucetaite, S. Strazdaite, V. Urboniene, F. Jankevicius

Proceedings Volume 7902, 790221 (2011) https://doi.org/10.1117/12.875258

KEYWORDS: Infrared spectroscopy, Infrared imaging, Spectroscopy, Imaging spectroscopy, Tissues, Tumors, Infrared radiation, Kidney, Tissue optics, Sensors

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Proceedings Article | 21 February 2008 Paper

Paper

Infrared spectroscopic imaging with high spatial resolution and high sensitivity

Valdas Sablinskas, Gerald Steiner, Justinas Ceponkus, Reiner Salzer

Proceedings Volume 6869, 68690X (2008) https://doi.org/10.1117/12.768977

KEYWORDS: Free electron lasers, Spectroscopy, Infrared radiation, Molecules, Gold, Infrared spectroscopy, Infrared imaging, Spatial resolution, Mirrors, FT-IR spectroscopy

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Proceedings Article | 25 January 2007 Paper

Paper

Formation of carbon coatings employing plasma torch from argon-acetylene gas mixture

Liutauras Marcinauskas, Alfonsas Grigonis, Pranas Valatkevicius, Valdas Sablinskas

Proceedings Volume 6596, 65961D (2007) https://doi.org/10.1117/12.726511

KEYWORDS: Carbon, Plasma, Atmospheric plasma, FT-IR spectroscopy, Raman spectroscopy, Silicon, Chemical vapor deposition, Silicon carbide, Scanning electron microscopy, Hydrogen

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Proceedings Article | 23 February 2006 Paper

Paper

Combination of SPR and PM-IRRAS for characterization and detection of biosensor arrays

Valdas Sablinskas, Gerald Steiner, Reiner Salzer

Proceedings Volume 6099, 60990I (2006) https://doi.org/10.1117/12.648360

KEYWORDS: Gold, Adsorption, Molecules, Aluminum, Spectroscopy, Image resolution, Self-assembled monolayers, Thin films, Infrared radiation, Spatial resolution

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Showing 5 of 24 publications

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