Dr. Wei Yang Profile

Dr. Wei Yang

at Univ of Texas MD Anderson Cancer Ctr

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Author

Publications (12)

SPIE Journal Paper | 23 February 2021 Open Access

Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data

Jeffrey Cochran, Anaïs Leproux, David Busch, Thomas O'Sullivan, Wei Yang, Rita Mehta, Alice Police, Bruce Tromberg, Arjun Yodh

JBO, Vol. 26, Issue 02, 026004, (February 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.2.026004

KEYWORDS: Tissues, Tumor growth modeling, Tumors, Tissue optics, Breast, Data modeling, Diffuse optical imaging, Breast cancer, Optical imaging, Optical spectroscopy imaging

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SPIE Journal Paper | 19 October 2018 Open Access

Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment

Jeffrey M. Cochran, David R. Busch, Anaïs Leproux, Zheng Zhang, Thomas D. O’Sullivan, Albert E. Cerussi, Philip M. Carpenter, Rita S. Mehta, Darren Roblyer, Wei Yang, Keith D. Paulsen, Brian Pogue, Shudong Jiang, Peter A. Kaufman, So Hyun Chung, Mitchell Schnall, Bradley S. Snyder, Nola Hylton, Stefan A. Carp, Steven J. Isakoff, David Mankoff, Bruce J. Tromberg, Arjun G. Yodh

JBO, Vol. 24, Issue 02, 021202, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.24.2.021202

KEYWORDS: Tumors, Tissues, Oxygen, Breast, Tissue optics, Data modeling, Breast cancer, Tumor growth modeling, Radiology, Magnetic resonance imaging

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Proceedings Article | 11 April 2018 Paper

Full-view 3D imaging system for functional and anatomical screening of the breast

Alexander Oraevsky, Richard Su, Ha Nguyen, James Moore, Yang Lou, Sayantan Bhadra, Luca Forte, Mark Anastasio, Wei Yang

Proceedings Volume 10494, 104942Y (2018) https://doi.org/10.1117/12.2318802

KEYWORDS: Breast, Optoacoustics, Imaging systems, Tumors, Transducers, Ultrasonography, Ultrasonics, 3D image processing, Diagnostics, Tomography

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Laser Optoacoustic Ultrasonic Imaging System Assembly (LOUISA-3D) was developed in response to demand of diagnostic radiologists for an advanced screening system for the breast to improve on low sensitivity of x-ray based modalities of mammography and tomosynthesis in the dense and heterogeneous breast and low specificity magnetic resonance imaging. It is our working hypothesis that co-registration of quantitatively accurate functional images of the breast vasculature and microvasculature, and anatomical images of breast morphological structures will provide a clinically viable solution for the breast cancer care. Functional imaging is LOUISA-3D is enabled by the full view 3D optoacoustic images acquired at two rapidly toggling laser wavelengths in the near-infrared spectral range. 3D images of the breast anatomical background is enabled in LOUISA-3D by a sequence of B-mode ultrasound slices acquired with a transducer array rotating around the breast. This creates the possibility to visualize distributions of the total hemoglobin and blood oxygen saturation within specific morphological structures such as tumor angiogenesis microvasculature and larger vasculature in proximity of the tumor. The system has four major components: (i) a pulsed dual wavelength laser with fiberoptic light delivery system, (ii) an imaging module with two arc shaped probes (optoacoustic and ultrasonic) placed in a transparent bowl that rotates around the breast, (iii) a multichannel electronic system with analog preamplifiers and digital data acquisition boards, and (iv) computer for the system control, data processing and image reconstruction. The most important advancement of this latest system design compared with previously reported systems is the full breast illumination accomplished for each rotational step of the optoacoustic transducer array using fiberoptic illuminator rotating around the breast independently from rotation of the detector probe. We report here a pilot case studies on one healthy volunteer and on patient with a suspicious small lesion in the breast. LOUISA3D visualized deoxygenated veins and oxygenated arteries of a healthy volunteer, indicative of its capability to visualize hypoxic microvasculature in cancerous tumors. A small lesion detected on optoacoustic image of a patient was not visible on ultrasound, potentially indicating high system sensitivity of the optoacoustic subsystem to small but aggressively growing cancerous lesions with high density angiogenesis microvasculature. The main breast vasculature (0.5-1 mm) was visible at depth of up to 40-mm with 0.3-mm resolution. The results of LOUISA-3D pilot clinical validation demonstrated the system readiness for statistically significant clinical feasibility study.

Proceedings Article | 22 March 2018 Open Access

Clinical applications of optical and optoacoustic imaging techniques in the breast

Wei Yang

Proceedings Volume 10573, 105730V (2018) https://doi.org/10.1117/12.2300519

KEYWORDS: Breast, Optoacoustics, Ultrasonography, Tissue optics, Breast cancer, Signal detection, Optical imaging, Tumors, Imaging systems, 3D image processing

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SPIE Journal Paper | 17 August 2017 Open Access

Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trial

Anaïs Leproux, Thomas O’Sullivan, Albert Cerussi, Amanda Durkin, Brian Hill, Nola Hylton, Arjun Yodh, Stefan Carp, David Boas, Shudong Jiang, Keith Paulsen, Brian Pogue, Darren Roblyer, Wei Yang, Bruce Tromberg

JBO, Vol. 22, Issue 12, 121604, (August 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121604

KEYWORDS: Absorption, Scattering, Calibration, Diffuse optical imaging, Optical imaging, Tissue optics, Reflectivity, Optical properties, Spectroscopes, Imaging spectroscopy

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Proceedings Article | 7 March 2016 Presentation + Paper

High resolution microendoscopy with structured illumination and Lugol's iodine staining for evaluation of breast cancer architecture

Jessica Dobbs, Matthew Kyrish, Savitri Krishnamurthy, Benjamin Grant, Henry Kuerer, Wei Yang, Tomasz Tkaczyk, Rebecca Richards-Kortum

Proceedings Volume 9703, 97030E (2016) https://doi.org/10.1117/12.2219352

KEYWORDS: Image resolution, Breast, Confocal microscopy, Iodine, Breast cancer, Optical imaging, Microscopy, Tissue optics, Image acquisition, Visualization, Luminescence

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SPIE Journal Paper | 28 October 2013 Open Access

Feasibility of confocal fluorescence microscopy for real-time evaluation of neoplasia in fresh human breast tissue

Jessica Dobbs, Hao Ding, Ana Benveniste, Henry Kuerer, Savitri Krishnamurthy, Wei Yang, Rebecca Richards-Kortum

JBO, Vol. 18, Issue 10, 106016, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.106016

KEYWORDS: Confocal microscopy, Luminescence, Tissues, Breast, Microscopy, Biopsy, Breast cancer, Pathology, Tissue optics, Visualization

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Proceedings Article | 23 March 2010 Paper

Detection of simulated microcalcifications in digital mammography: effects of quantum and anatomic noises: preliminary study

Chao-Jen Lai, Xinming Liu, Zhicheng You, Youtao Shen, Yuncheng Zhong, Lingyun Chen, Tao Han, Shuaiping Ge, Ying Yi, William Geiser, David Flores, Gary Whitman, Wei Yang, Chris Shaw

Proceedings Volume 7622, 76224Y (2010) https://doi.org/10.1117/12.844426

KEYWORDS: Breast, Digital mammography, Signal to noise ratio, Mammography, LCDs, Visibility, X-rays, Target acquisition, Tissues, Image processing

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Proceedings Article | 11 March 2009 Paper

Breast density measurement: 3D cone beam computed tomography (CBCT) images versus 2D digital mammograms

Tao Han, Chao-Jen Lai, Lingyun Chen, Xinming Liu, Youtao Shen, Yuncheng Zhong, Shuaiping Ge, Ying Yi, Tianpeng Wang, Wei Yang, Chris Shaw

Proceedings Volume 7258, 72580L (2009) https://doi.org/10.1117/12.813823

KEYWORDS: Breast, Image segmentation, Tissues, Mammography, 3D image processing, Computed tomography, Breast cancer, 3D metrology, Radiology, Sensors

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Proceedings Article | 2 March 2006 Paper

Effects of radiation dose level on calcification visibility in cone beam breast CT: a preliminary study

Chao-Jen Lai, Chris Shaw, Mustafa Altunbas, Yang Meng, Lingyun Chen, Shu-Ju Tu, Tianpeng Wang, Xinming Liu, Wei Yang, Gary Whitman

Proceedings Volume 6142, 614233 (2006) https://doi.org/10.1117/12.656471

KEYWORDS: Breast, Mammography, X-rays, Radiation effects, Sensors, Imaging systems, Tissues, Breast cancer, X-ray imaging, Breast imaging

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Proceedings Article | 20 April 2005 Paper

Dual-energy digital mammography for calcification imaging: improvement by post-image processing

S. Kappadath, Chris Shaw, Chao-Jen Lai, Xinming Liu, Gary Whitman, Wei Yang

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.596903

KEYWORDS: Image processing, Tissues, X-rays, Sensors, Digital mammography, Breast, Image filtering, X-ray imaging, Signal processing, Imaging systems

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Proceedings Article | 20 April 2005 Paper

Analysis of confidence level scores from an ROC study: comparison of three mammographic systems for detection of simulated calcifications

Chao-Jen Lai, Chris Shaw, Gary Whitman, Wei Yang, Peter Dempsey

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.597212

KEYWORDS: Imaging systems, Mammography, CCD cameras, Control systems, Charge-coupled devices, Sensors, Digital mammography, X-rays, Breast, Tissues

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Showing 5 of 12 publications

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