We developed a smartphone-based epifluorescence microscope for fresh tissue imaging. The smartphone microscope optics was optimally designed to achieve similar resolution (0.56 μm) and FOV (520 μm) as the bench 40x microscope, commonly used during the histopathologic analysis. Preliminary images obtained from an excised human pancreatic tissue stained with a rapid staining fluorescence dye (PARPi-FL) clearly visualized individual tumor cells.
The electric field or stress applied to a solid material can change its polarization or dimensions, thereby altering its properties and causing a piezoelectric effect. This effect can positively or negatively impact your material depending on the sought after application. In this paper, we present a quantitative COMSOL simulation on the influence of the piezoelectric effect on the performance of high speed KTN deflectors. This includes examining the following aspects: piezoelectric induced mechanical stress and refractive index modulation. Furthermore, methods of minimizing the negative impact of piezoelectric effect, such as soft clamping, are explored in order to optimize the performance of electro-optical deflectors.
In this paper, we quantitatively simulate the thermal effect of charging and discharging process of high speed KTN beam deflector. The influence of thermal effect on beam quality is quantitatively analyzed. The method of reducing the thermal effect via a multi-layer design is also explored.
To minimize the influence of the refractive index mismatch between transparent conductive layer (e.g. Indium Tin Oxide (ITO)) and glass substrate on the light outcoupling efficiency (LOE) of organic light emitting diode (OLED), in this paper, we present a blue OLED with high LOE by incorporating a layer of tilted nanotube array as an internal light extraction structure in an optimal location. In comparison with conventional planar OLED, the LOE can be increased from 10.9 to 55.3%. The increase in LOE is mainly due to the strong disruption of waveguided mode. The tilted structure can be potentially used to develop high efficiency OLEDs.
In this paper, we present a novel large capacity (a 1000+ channel) time division multiplexing (TDM) laser beam combining technique by harnessing a state-of-the-art nanosecond speed potassium tantalate niobate (KTN) electro-optic (EO) beam deflector as the time division multiplexer. The major advantages of TDM approach are: (1) large multiplexing capability (over 1000 channels), (2) high spatial beam quality (the combined beam has the same spatial profile as the individual beam), (3) high spectral beam quality (the combined beam has the same spectral width as the individual beam, and (4) insensitive to the phase fluctuation of individual laser because of the nature of the incoherent beam combining. The quantitative analyses show that it is possible to achieve over one hundred kW average power, single aperture, single transverse mode solid state and/or fiber laser by pursuing this innovative beam combining method, which represents a major technical advance in the field of high energy lasers. Such kind of 100+ kW average power diffraction limited beam quality lasers can play an important role in a variety of applications such as laser directed energy weapons (DEW) and large-capacity high-speed laser manufacturing, including cutting, welding, and printing.
This paper presents an ultra-fast growth of silicon carbide crystal with the size up to 50 μm from SiC nanopowders. By using a CO2 laser with a power of 30W to heat the silicon carbide nanopowders in a vacuum chamber, the nanopowders tends to congregate together to form larger particles first. Following the slow cooling process, the congregate formation would further transform to final SiC micro-crystals. The two types of final products grown from quenching process and slow cooling process were analyzed by SEM. The lattice structure of final SiC micro-crystal was determined to be hexagonal structure according to the XRD analysis.
This paper presents a quantitative two-dimensional (2D) analysis on high power GaN light emitting diodes (LEDs) fabricated on asymmetric micro-structured substrates. It is found that the light extraction efficiency (LEE) can be substantially improved from conventional symmetric structure to asymmetric structure. The increase of LEE is mainly dedicated to the increased surface area and better randomization on the direction of transmitted/reflected light, which enhances the escaping probability after multiple reflections. This quantitative 2D analysis lays down a solid foundation for the future quantitative 3D analysis.
This paper presents a nanosecond speed KTN varifocal lens. The tuning principle of varifocal lens is based on the high-speed refractive index modulation from the nanosecond speed tunable electric field. A response time on the order of nanoseconds was experimentally demonstrated, which is the fastest varifocal lens reported so far. The results confirmed that the tuning speed of the KTN varifocal lens could be significantly increased by avoiding the electric field induced phase transition. Such a nanosecond speed varifocal lens can be greatly beneficial for a variety of applications that demand high speed axial scanning, such as high-resolution 3D imaging and high-speed 3D printing.
In this paper, a multi-dimensional KTN beam deflector is presented. The multi-scanning mechanisms, including space-charge-
controlled beam deflection, composition gradient-induced beam deflection, and temperature gradient-induced
beam deflection are harnessed. Since multi-dimensional scanning can be realized in a single KTN crystal, it represents a
compact and cost-effective approach to realize multi-dimensional scanning, which can be very useful for many
applications, including high speed, high resolution imaging, and rapid 3D printing.
This study reports a high light extraction efficiency (LEE) light emitting diode (LED) by harnessing asymmetric obtuse
angle micro-structured roofs. In comparison to conventional symmetric micro-structured roofs, the LEE has been
improved from 62% to 73%. This represents an 11% improvement in LEE, which is significant for LED. It is
speculated that this improvement is largely due to the increased surface area and better randomization on the direction of
transmitted/reflected light, which enhances the escaping probability after multiple reflections.
A non-uniform space charge-controlled KTN beam deflector is presented and analyzed. We found that a non-uniform
space charge can result in a non-uniform beam deflection angles. This effect can be useful for some applications such as
electric field controlled beam separation. However, a non-uniform space charge needs to be avoided if one wants uniform
beam deflection throughout the entire crystal.
In this paper, based on the theory of dynamic waveguiding effect in nanodisordered KTN crystals, a detailed design and implementation of a super broadband 1x2 high speed waveguide switch is presented. The important waveguide parameters, including the dimension, the refractive index distribution, and the electric field distribution within the waveguide are quantitatively simulated and analyzed. An experimental verification of switching effect based on the design is also conducted, which confirmed the design. The broadband and high speed nature of such kind of switch can play a key role in data center networks and cloud computing, which needs low power consumption and high speed switches.
In this paper, a nanosecond speed KTN beam deflector is presented. The beam deflector is based on the combination of pre-injected space charge field and high speed (nanosecond) switching field. A beam deflection speed on the order of nanosecond was demonstrated, which was fastest beam deflection speed reported so far. The experimentally results confirmed that the speed limitation of KTN beam deflector was not limited by the electro-optic (EO) effect itself but the driving electric source and circuit. With a faster speed driving source and circuit, it is possible to develop GHz frequency beam deflector.
In this paper, a new type of waveguide switch-field induced dynamic optical waveguide switch is presented. The switching
mechanism is based on electric-field induced dynamic waveguiding effect in nanodisordered potassium tantalate niobate
(KTN) crystals. By applying an electric field at different locations, different waveguide paths are created, which result in
different output locations. The major advantages of this unique optical switch are broad bandwidth, covering the entire
1300 nm – 1600 nm fiber optic communication window, and ultrafast switching speed (on the order of nanosecond), which
can be very useful for next generation optical networks such as the one used in data center networks.
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