Ms. Wenjuan Wu Profile

Wenjuan Wu

at Xi'an Jiaotong Univ

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SPIE Journal Paper | 23 November 2017 Open Access

Nd:YAG laser combined with gold nanorods for potential application in port-wine stains: an in vivo study

Linzhuang Xing, Bin Chen, Dong Li, Wenjuan Wu, Guo-Xiang Wang

JBO, Vol. 22, Issue 11, 115005, (November 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.11.115005

KEYWORDS: Nd:YAG lasers, Blood, Laser energy, Blood vessels, Skin, Pulsed laser operation, Absorption, Gold, Nanorods, Magnesium

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Neodymium:yttrium aluminum garnet (Nd:YAG) lasers exhibit considerable potential for treating deeply buried port-wine stains. However, the application of Nd:YAG laser is limited by its weak absorption to blood. This in vivo study tested the efficacy and safety of utilizing thiol-terminated methoxypolyethylene glycol-modified gold nanorods (PEG-GNRs) to enhance the absorption of Nd:YAG laser to blood. Mouse mesentery and dorsal skinfold chamber (DSC) model were prepared to analyze the thermal responses of a single venule without anatomic structures, as well as blood vessels in the complex structure of the skin, to laser light. After the injection of 0.44 mg of PEG-GNRs, the required threshold density of laser energy for blood coagulation and complete vasoconstriction decreased from 24 to 18 J/cm2 in the mesentery model and from 36 to 31 J/cm2 in the DSC model. The laser pulse required for blood coagulation and complete vasoconstriction decreased by 67.75% and 62.25% on average in the mesentery model and by 67.55% and 54.45% on average in the DSC model. Histological and histochemical results confirmed that PEG-GNRs are nontoxic in the entire mouse life span. Therefore, combining PEG-GNRs with Nd:YAG laser may be effective and safe for inducing an obvious thermal response of blood vessels under low energy density and minimal pulse conditions.

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